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Ciccarone Center Research
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- Meet the Authors
Published in: Journal of the American College of CardiologyRead on Pubmed
Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.Published in: Mayo Clinic ProceedingsRead on Pubmed
Prognostic value of cardiac troponins in chronic kidney disease patients without a suspected acute coronary syndrome: a systematic review.
In chronic kidney disease patients without suspected acute coronary syndromes, troponin elevations were associated with worse prognosis.Published in: Annals of Internal MedicineRead on Pubmed
To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.Published in: Journal of the American Heart AssociationRead on Pubmed
This is a state-of-art review on the possible effects of statin therapy on organs not in the cardiovascular system.Published in: British Medical JournalRead on Pubmed
Headed in the right direction but at risk for miscalculation: a critical appraisal of the 2013 ACC/AHA risk assessment guideline.
The newly released 2013 ACC/AHA Guideline for Assessing Cardiovascular Risk was a major advance over prior guidelines, but the new risk equations do not appear to lead to significantly better discrimination than older models. Since the same risk factors are incorporated, using the new risk estimators may lead to inaccurate assessment of atherosclerotic cardiovascular risk in certain groups of patients. There also is likely an overestimation of risk when applied to modern populations. Future guidelines could provide clearer direction on which individuals would benefit from additional testing for more personalized preventive therapies.Published in: Journal of the American College of CardiologyRead on Pubmed
Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly.
Reduced zinc intake has been related to atherogenesis and arteriosclerosis. We verified this assumption in very old individuals, who are particularly prone to both zinc deficiency and structural and functional changes in the arterial wall. Although plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall. In the very elderly, plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis, or atherosclerotic burden at coronary or carotid arteries.
The prognostic value of exercise capacity in patients with coronary artery disease: The FIT Project.
Exercise capacity was a strong predictor of morbidity and mortality in patients with coronary artery disease. Patients with similar exercise capacities had equivalent mortality risk, irrespective of baseline revascularization status.
Mild cognitive dysfunction does not affect diabetes control in minority elders.
Mild cognitive impairment was not associated with metabolic control of diabetes among minority elderly individuals.Read on Pubmed
Significant depressive symptoms are not associated with diabetes control in minority elderly.
Elevated depressive symptoms were not associated with metabolic control of diabetes among minority elderly individuals.
Early readmission among patients with diabetes: A qualitative assessment of contributing factors.
Findings from this qualitative study suggest several interventions that may reduce the risk of early readmission for patients with diabetes, including inpatient diabetes education, improving communication of discharge instructions, and involving patients more in medication reconciliation and post-discharge planning.Read on Pubmed
The wait is over: The new cholesterol treatment guidelines are here.
Well-intentioned CV specialists often disagree, but we wholeheartedly support at least 90% of the new guidelines, which declare that primary prevention is here to stay. While many more adults will now qualify for statin therapy, heart-healthy dietary and exercise habits remain the foundation of primary prevention efforts. Following these new guidelines will allow clinicians to markedly reduce CVD events in their patients.
Stability and predictors of change in salivary cortisol measures over six years: The Multi-Ethnic Study of Atherosclerosis.
All features of the daily cortisol curve changed significantly over the approximately six year follow-up period—the wakeup cortisol became higher; the cortisol awakening response became smaller; both the early and late decline became flatter and the area under the curve became larger.Read on Pubmed