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Ciccarone Center Research
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- Meet the Authors
Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.
These findings reveal extensive metabolic remodeling common to both hypertrophic and failing hearts that are indicative of extracellular matrix remodeling, insulin resistance and perturbations in amino acid, and lipid and nucleotide metabolism.Read on Pubmed
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
This integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, long-QT syndrome, and sudden cardiac death.Read on Pubmed
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.
This large, whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments.
Genetics and personalized medicine — a role in statin therapy?
The primary goal of this study was to feature the most important genes involved in lipid metabolism, clinical outcomes, and statin-induced side effects, highlighting genomewide association studies and the candidate gene approach.The primary goal of this study was to feature the most important genes involved in lipid metabolism, clinical outcomes, and statin-induced side effects, highlighting genome-wide association studies and the candidate gene approach.
APOE modulates the correlation between triglycerides, cholesterol, and CHD through pleiotropy, and gene-by-gene interactions.
The relationship between total cholesterol and triglycerides varies by apolipoprotein E isoform genotype in African-American and European-American populations.
No association of 9p21 with arterial elasticity and retinal microvascular findings.
This study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.
Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Common genetic variation in platelet endothelial aggregation receptor-1 may be a determinant of platelet response and cardiovascular events in patients on aspirin alone or in combination with clopidogrel.
Genetic associations with valvular calcification and aortic stenosis.
Genetic variation in the lipoprotein(a) locus, mediated by lipoprotein(a) levels, is associated with aortic valve calcification across multiple ethnic groups and with incident clinical aortic stenosis.
Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.
In the largest genome-wide association study of cardiac structure and function to date in African-Americans, researchers identified 4 genetic loci related to left ventricular mass, interventricular septal wall thickness, left ventricular internal diastolic diameter, and ejection fraction, which reached genome-wide significance.
The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish.
Although the G574R variant is associated with moderately elevated plant sterol levels, carriers of the 574R allele had modestly lower levels of carotid wall thickness compared with noncarriers.