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Ciccarone Center Research

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Heart Rate

Delayed heart rate recovery is strongly associated with early and late stage prehypertension during exercise stress testing.
By: Aneni E, Roberson LL, Shaharyar S, Blaha MJ, Agatston A, Blumenthal RS, Meneghelo RS, Conceiçao RD, Nasir K, Santos RD.
Among asymptomatic patients undergoing stress testing delayed HRR was independently associated with early and late stages of prehypertension. Further studies are needed to determine the usefulness of HRR measure in the prevention and management of hypertension.
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Delayed heart rate recovery is strongly associated with early and late-stage prehypertension during exercise stress testing.
By: Aneni E, Roberson LL, Shaharyar S, Blaha MJ, Agatston AA, Blumenthal RS, Meneghelo RS, Conceiçao RD, Nasir K, Santos RD.
Among asymptomatic patients undergoing stress testing, delayed heart rate recovery was independently associated with early and late stages of prehypertension.
Read on Pubmed
Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
By: Opdahl A, Ambale Venkatesh B, Fernandes VR, Wu CO, Nasir K, Choi EY, Almeida AL, Rosen B, Carvalho B, Edvardsen T, Bluemke DA, Lima JA.
Elevated resting heart rate was associated with increased risk for incident HF in asymptomatic participants in the MESA trial; higher heart rate was related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
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Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen): from the Multi-Ethnic Study of Atherosclerosis.
By: Whelton SP, Narla V, Blaha MJ, Nasir K, Blumenthal RS, Jenny NS, Al-Mallah MH, Michos ED.
Heart rate (HR) at rest is associated with adverse cardiovascular events; however, the biologic mechanism for the relation is unclear. An increased HR at rest was associated with a higher level of inflammation among an ethnically diverse group of subjects without known cardiovascular disease.
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Response to importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness.
By: Whelton SP, Blaha MJ.
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Influence of image acquisition on radiation dose and image quality: full versus narrow phase window acquisition using 320 MDCT.
By: Khosa F, Khan A, Nasir K, Shuaib W, Budoff M, Blankstein R, Clouse ME.
Good heart rate control and predefined narrow window acquisition result in lower radiation dose, without compromising diagnostic image quality for coronary disease evaluation.
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Association of resting heart rate with carotid and aortic arterial stiffness: Multi-Ethnic Study of Atherosclerosis.
By: Whelton SP, Blankstein R, Al-Mallah MH, Lima JA, Bluemke DA, Hundley WG, Polak JF, Blumenthal RS, Nasir K, Blaha MJ.

Results from this study suggest that a higher resting heart rate is associated with an increased arterial stiffness independent of atrioventricular nodal blocker use and physical activity level, with a stronger association for a peripheral (carotid) compared with a central (aorta) artery.

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Impaired left ventricular filling in COPD and emphysema: Is it the heart or the lungs?: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.
By: Smith BM, Prince MR, Hoffman EA, Bluemke DA, Liu CY, Rabinowitz D, Hueper K, Parikh M, Gomes AS, Michos ED, Lima J, Barr RG.

These findings support a mechanism of upstream pulmonary causes of underfilling of the left ventricle in COPD and in patients with emphysema on computed tomography.

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Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs. nonstrict electrocardiogram criteria for left bundle-branch block.
By: Andersson LG, Wu KC, Wieslander B, Loring Z, Frank TF, Maynard C, Gerstenblith G, Tomaselli GF, Weiss RG, Wagner GS, Ugander M, Strauss DG.
This study found there was no significant difference between patients with nonstrict left bundle-branch block and non-left bundle-branch block. The greater observed LV dyssynchrony may explain why patients with strict left bundle-branch block have a better response to cardiac resynchronization therapy.
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The relationship between resting heart rate and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA).
By: Rubin J, Blaha MJ, Budoff MJ, Rivera JJ, Shaw LJ, Blankstein R, Mallah MA, Carr JJ, Jones DL, Blumenthal RS, Nasir K.
We conclude that elevated resting heart rate, a well-described predictor of cardiovascular mortality with unclear mechanism, is associated with increased incidence and progression of coronary atherosclerosis among individuals free of CVD at baseline.
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