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Ciccarone Center Research
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- Antiplatelet Therapy
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- Family History of CVD
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- Meet the Authors
Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.Published in: Mayo Clinic ProceedingsRead on Pubmed
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.Published in: American Journal of CardiologyRead on Pubmed
Coronary artery plaque, especially noncalcified plaque, is more prevalent and extensive in HIV-infected men, independent of CAD risk factors.Published in: Annals of Internal MedicineRead on Pubmed
Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease?: Clinical risk scores are not sufficient to define primary prevention treatment strategies among asymptomatic patients.Read on Pubmed
Subclinical atherosclerosis testing with CAC is currently superior to any combination of risk factors and serum biomarkers.
Critical review of high-sensitivity C-reactive protein and coronary artery calcium for the guidance of statin allocation: head-to-head comparison of the JUPITER and St. Francis Heart Trials.Read on Pubmed
This analysis looks at the strengths and limitations of two large trials of statin therapy based on persons with an elevated hsCRP, CAC score, or both.
Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis.Read on Pubmed
CAC scoring can help match statin therapy to absolute atherosclerotic CVD risk.
Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infection.
These data suggest that, in order to reduce the risk for coronary artery disease in HIV-infected African-Americans, vitamin D levels should be closely monitored. These data also suggest that clinical trials should be conducted to examine whether vitamin D supplementations reduce the risk of CAD in this population.Read on Pubmed
Comparative effectiveness of risk markers for cardiovascular risk assessment in intermediate-risk individuals: coronary artery calcium versus “the rest”?
We evaluated four large population-based cohort studies regarding the net reclassification index (NRI) among intermediate risk patients. We concluded that the coronary artery calcium score was the strongest marker for clinical risk prediction and is the most likely to influence future clinical outcomes.
Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: Results from MESA.
Unhealthy lifestyle habits are a major contributor to coronary artery disease (CAD). The purpose of the study was to investigate the associations of smoking, weight maintenance, physical activity, and Mediterranean-style diet with coronary calcium, cardiovascular events, and mortality. We discovered that, over the course of nearly 8 years, a combination of regular exercise, healthy diet, smoking avoidance, and weight maintenance contributed to lower coronary calcium incidence, slower calcium progression, and lower all-cause mortality.
Family history of coronary heart disease (CHD) and markers of subclinical cardiovascular disease: Where do we stand?
Family history of coronary artery disease is associated with markers of subclinical atherosclerosis, and this relationship remains statistically significant after adjusting for traditional risk factors. Our data suggest these individuals should be considered strongly as candidates for assessment of subclinical CVD to further refine risk and treatment goals.
Establishing a successful coronary CT angiography program in the emergency department: Official writing of the Fellow and Resident Leaders of the Society of Cardiovascular Computed Tomography (FiRST).
Recent multicenter trials have reported that coronary CT angiography is safe, reduces time to diagnosis, facilitates discharge, and may lower overall cost compared with routine care. This study provides a 10-step approach for establishing a successful coronary CT angiography program in the emergency department.Read on Pubmed
Use of cardiac CT angiography imaging in an epidemiology study: the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy.
This study concluded that cardiac CT angiography may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low-risk populations while minimizing radiation exposure.Read on Pubmed
Progression of coronary calcium and incident CHD events: MESA (Multi-Ethnic Study of Atherosclerosis).
This study concluded that progression of coronary artery calcium (CAC) is associated with an increased risk for future heart disease events, even after controlling for other potentially confounding factors.
Genetic associations with valvular calcification and aortic stenosis.
Genetic variation in the lipoprotein(a) locus, mediated by lipoprotein(a) levels, is associated with aortic valve calcification across multiple ethnic groups and with incident clinical aortic stenosis.
Gender differences in coronary plaque composition and burden detected in symptomatic patients referred for coronary computed tomographic angiography.
This study found that symptomatic women have a lower prevalence of obstructive coronary artery disease and are less likely to have mixed coronary plaque compared to symptomatic men. Future studies are needed to determine the prognostic implications of these findings.
What is the role of calcium scoring in the age of coronary computed tomographic angiography?
Available data suggest that in low-to-intermediate risk symptomatic patients, CAC scanning may serve as an appropriate gatekeeper to further testing with either coronary computed tomographic angiography, functional imaging, or invasive coronary angiography.