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Ciccarone Articles

Ciccarone Center Research



Landmark Articles

Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study.
By: Lutsey PL, Alonso A, Michos ED, Loehr LR, Astor BC, Coresh J, Folsom AR.
Low serum magnesium and high serum phosphorus and calcium were independently associated with greater risk of incident HF in this population-based cohort.
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Is LDL-C measurement better than estimating absolute risk for treating increased cholesterol?
By: Feldman DI, Martin SS.

LDL-C measurements and absolute risk assessments are important and provide complimentary information. More research is needed, but based on the best available evidence it appears that a balance of estimating risk (ARR) and measuring LDL-C (RRR) is appropriate. 

Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.
By: Sansbury BE, De Martino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG.
These findings reveal extensive metabolic remodeling common to both hypertrophic and failing hearts that are indicative of extracellular matrix remodeling, insulin resistance and perturbations in amino acid, and lipid and nucleotide metabolism.
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Hot, cool, cold: The future of phospholipid A2 as a therapeutic target for CHD.
By: Houston B, Martin SS.
This article reviewed the state-of-the-art research involving inhibition of phospholipid A2 to reduce subsequent cardiovascular events.
Coronary artery calcium testing: exploring the need for a randomized trial.
By: McEvoy JW, Blaha MJ.
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Cigarette smoking worsens systemic inflammation in persons with metabolic syndrome.
By: Jamal O, Aneni EC, Shaharyar S, Ali SS, Parris D, McEvoy JW, Veledar E, Blaha MJ, Blumenthal RS, Agatston AS, Coceicao RD, Feldman T, Carvalho JA, Santos RD, Nasir K.

Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interaction can be explained by an additive increase in the risk of systemic inflammation by MetS and cigarette smoking. The study demonstrates an additive effect of cigarette smoking on the risk of systemic inflammation in MetS thus highlighting the need for determining smoking status among those with MetS and aggressively targeting smoking cessation in this population.

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Coronary artery disease detected by coronary CT angiography is associated with intensification of preventive medical therapy and lower LDL cholesterol.
By: Hulten E, Bittencourt MS, Singh A, O’Leary D, Christman MP, Osmani W, Abbara S, Steigner M, Truong QA, Nasir K, Rybicki F, Klein J, Hainer J, Brady TJ, Hoffmann U, Ghoshhajra B, Hachamovitch R, Di Carli MF, Blankstein R.
Coronary computed tomography angiography (CCTA) may lead to increased use of prognostically beneficial therapies in patients identified as having extensive, non-obstructive CAD.
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The turing test and a call to action to improve electronic health record documentation.
By: McEvoy JW.

Clinical informatics represents arguably the most significant advance in medicine since the deciphering of the human genome. In particular, as the “front end” of the clinical informatics revolution, the electronic health record has immense potential to transform modern healthcare. Demonstrated benefits of the electronic health record include decision support, adverse event tracking, and quality control.1 An additional strength of the electronic health record is an inherent capacity to augment research, including embedded, randomized, controlled clinical trials.

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Neck circumference is not associated with subclinical atherosclerosis in retired national football league players.
By: Pokharel Y, Macedo FY, Nambi V, Martin SS, Nasir K, Wong ND, Boone J, Roberts AJ, Ballantyne CM, Virani SS.
In retired NFL players with a high prevalence of CAC and carotid artery plaque, neck circumference was not associated with coronary or carotid subclinical atherosclerosis.
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Vitamin D and subclinical cerebrovascular disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study.
By: Michos ED, Carson KA, Schneider AL, Lutsey PL, Xing L, Sharrett AR, Alonso A, Coker LH, Gross M, Post W, Mosley TH, Gottesman RF.
single measure of 25-hydroxy vitamin D was not cross-sectionally associated with white matter hyper-intensities grade or prevalent subclinical infarcts and was not prospectively associated with their progression or subclinical brain infarcts seen on serial cerebral MRIs obtained approximately 10 years apart.
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