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Ciccarone Articles

Ciccarone Center Research

Year

2014

Landmark Articles

Coronary artery calcium score.
By: Polonsky TS, Blumenthal RS, Greenland P.
Read on Pubmed
Rationale and design of the Henry Ford exercise testing project (The FIT Project).
By: Al-Mallah MH, Keteyian SJ, Brawner CA, Whelton S, Blaha MJ.
The FIT Project, the largest study of physical fitness to date, uses electronic clinical epidemiologic techniques to answer many clinically relevant questions related to exercise capacity and prognosis.
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Low HDL cholesterol but not high LDL cholesterol is independently associated with subclinical coronary atherosclerosis in healthy octogenarians.
By: Freitas WM, Quaglia LA, Santos SN, de Paula RC, Santos RD, Blaha M, Rivera JJ, Cury R, Blumenthal R, Nadruz-Junior W, Agatston A, Figueiredo VN, Nasir K, Sposito AC; The Brazilian Study on Healthy Aging.

In a healthy cohort of individuals aged of 80 years or more the association between LDL-C and coronary atherosclerosis weakens with aging, while the opposite occurs with the levels of HDL-C.

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NIDDK international conference report on diabetes and depression: Current understanding and future directions.
By: Holt RIG, deGroot M, Lucki I, Hunter CM, Sartorius N, Golden SH.
Comorbid diabetes and depression are a major clinical challenge as the outcomes of each condition are worsened by the other. This article summarizes the presentations and discussions during an international meeting on diabetes and depression convened by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in collaboration with the National Institute of Mental Health and the Dialogue on Diabetes and Depression.
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Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter AIDS Cohort Study.
By: Miller PE, Budoff M, Zikusoka M, Li X, Palella F Jr, Kingsley LA, Witt MD, Sharrett AR, Jacobson LP, Post WS.
The lower prevalence of CAC in black men compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
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Association of high-density lipoprotein subclasses and incident coronary heart disease: The Jackson Heart and Framingham Offspring cohort studies.
By: Joshi PH, Toth PP, Lirette ST, Griswold ME, Massaro JM, Martin SS, Blaha MJ, Kulkarni KR, Khokhar AA, Correa A, D’Agostino Sr RB, Jones SR, on behalf of the Lipoprotein Investigators Collaborative (LIC) Study Group.
This study found that smaller, denser HDL3-C levels are primarily responsible for the inverse association between HDL-C and incident CHD in this diverse group of primary prevention subjects.
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High-density lipoprotein subfractions: current views and clinical practice applications.
By: Martin SS, Jones SR, Toth PP.
This report prioritizes higher-resolution HDL measurement techniques that capture better the biologically and clinically important characteristics of HDL.
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Troponin elevations only detected with a high-sensitivity assay: Clinical correlations and prognostic significance.
By: Korley FK, Schulman SP, Sokoll LJ, DeFilippis AP, Stolbach AI, Bayram JD, Saheed MO, Omron R, Fernandez C, Lwin A, Cai SS, Post WS, Jaffe AS.

With clinical use of high-sensitivity troponin I (hsTnI), more frequent troponin elevations will occur. However, the burden and implications of these elevations are not well understood. The authors quantified the prevalence of elevated hsTnI in patients presenting with possible acute coronary syndrome (ACS) who do not have elevated troponin with a current generation assay (cardiac troponin I [cTnI]) and determined the association of these newly detected elevations with a composite of all-cause mortality and subsequent cardiac hospitalization. On the initial sample, 9% to 11% of subjects without cTnI elevation had hsTnI elevation. Although the majority of the patients with these newly detected hsTnI elevations did not have ACS, they had a higher risk for all-cause mortality and subsequent cardiac hospitalization.

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New insights into diagnostic testing guidelines in women.
By: Metkus Jr. TS, Blumenthal RS, Joshi PH.

An update to the 2005 Guidelines on the Role of Noninvastive Testing in the Clinical Evaluation of Women with Suspected Ischemic Heart Disease was authored in response to the documented gap in appropriate diagnosis and treatment of ischemic heart disease between women and men.

Non-cardiovascular effects associated with statins.
By: Desai CS, Martin SS, Blumenthal RS.
This is a state-of-art review on the possible effects of statin therapy on organs not in the cardiovascular system.
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