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Ciccarone Articles

Ciccarone Center Research


Cardiovascular Risk Assessment

Landmark Articles

Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.
By: Kanaya AM, Kandula NR, Ewing SK, Herrington D, Liu K, Blaha MJ, Srivastava S, Dave SS, Budoff MJ.
A high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.
Read on Pubmed
Nonfatal outcomes in the primary prevention of atherosclerotic cardiovascular disease: is all-cause mortality really all that matters?
By: Czarny MJ, Martin SS, Kohli P, Metkus T, Blumenthal RS.
This article clearly shows that major nonfatal cardiovascular outcomes are very important to take into account when designing primary prevention guidelines.
Read on Pubmed
Use of coronary artery calcium testing to guide aspirin utilization for primary prevention: estimates from the multi-ethnic study of atherosclerosis.
By: Miedema MD, Duprez DA, Misialek JR, Blaha MJ, Nasir K, Silverman MG, Blankstein R, Budoff MJ, Greenland P, Folsom AR.
For the primary prevention of coronary heart disease (CHD), MESA participants with coronary artery calcium (CAC) ?100 were shown to have favorable risk/benefit estimations for aspirin use, while participants with zero CAC were estimated to receive net harm from aspirin.
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Baseline subclinical atherosclerosis burden and distribution are associated with frequency and mode of future coronary revascularization: multi-ethnic study of atherosclerosis.
By: Silverman MG, Harkness JR, Blankstein R, Budoff MJ, Agatston AS, Carr JJ, Lima JA, Blumenthal RS, Nasir K, Blaha MJ.
There was a strong association between the baseline burden and regional distribution of CAC and the risk and type of future coronary revascularization among asymptomatic subjects.
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Genetically low triglycerides and mortality: further support for “the earlier the better”?
By: Martin SS, Blaha MJ.
Read on Pubmed
Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.
By: Ratchford EV, Carson KA, Jones SR, Ashen MD.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.
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Screening low-risk individuals for coronary artery disease.
By: Desai CS, Blumenthal RS, Greenland P.
Data regarding the role of additional testing in low-risk populations to improve early detection or to enhance risk assessment indicate that CAC and the ankle-brachial index (ABI) may be helpful for improving risk classification and detecting the higher-risk people from among those at lower risk.
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Risk and the physics of clinical prediction.
By: McEvoy JW, Diamond GA, Detrano RC, Kaul S, Blaha MJ, Blumenthal RS, Jones SR.
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
Read on Pubmed
2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk.
By: Abd TT, Misra S, Ojeifo O, Martin SS, Blumenthal RS, Foody J, Wong ND.
The 2013 lifestyle guidelines provide guidance in three narrowly focused areas: 1) the effect of dietary patterns and macronutrient composition on CVD risk factors; 2) the effect of sodium and potassium on CVD risk factors; and 3) the effect of physical activity on blood pressure and lipids.
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Delayed heart rate recovery is strongly associated with early and late-stage prehypertension during exercise stress testing.
By: Aneni E, Roberson LL, Shaharyar S, Blaha MJ, Agatston AA, Blumenthal RS, Meneghelo RS, Conceiçao RD, Nasir K, Santos RD.
Among asymptomatic patients undergoing stress testing, delayed heart rate recovery was independently associated with early and late stages of prehypertension.
Read on Pubmed