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Ciccarone Articles

Ciccarone Center Research

Journal

Atherosclerosis

Plaque composition and stenosis severity: is there any hope for plaque regression?
By: Al-Mallah MH, Nasir K.
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Association between sleep apnea, snoring, incident cardiovascular events and all-cause mortality in an adult population: MESA.
By: Yeboah J, Redline S, Johnson C, Tracy R, Ouyang P, Blumenthal RS, Burke GL, Herrington DM.
We assessed the association between sleep apnea, snoring, incident CV events and all-cause mortality in the Multi Ethnic Study of Atherosclerosis (MESA) cohort and concluded that sleep apnea, but not habitual snoring, was associated with high incident CV events and all-cause mortality in a multi-ethnic population-based study of adults free of clinical CV disease at baseline.
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Differentiation of severe coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis.
By: Coylewright M, Rice K, Budoff MJ, Blumenthal RS, Greenland P, Kronmal R, Barr RG, Burke GL, Tracy R, Post WS.
Both high and very high levels of coronary artery calcium are associated with an elevated risk of CHD events in those without symptomatic CHD at baseline; however, very high CAC is associated with an increased risk of angina, but not CHD death or MI, as compared to high CAC.
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Differentiation of severe coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis.
By: Coylewright M, Rice K, Budoff MJ, Blumenthal RS, Greenland P, Kronmal R, Barr RG, Burke GL, Tracy R, Post WS.
Both high and very high CAC are associated with an elevated risk of CHD events in those without symptomatic CHD at baseline; however, very high CAC is associated with an increased risk of angina, but not CHD death or MI, compared to high CAC scores.
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The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis.
By: Tison GH, Blaha MJ, Budoff MJ, Katz R, Rivera JJ, Bertoni AG, Wong ND, Blumenthal RS, Szklo M, Eng J, Tracy R, Nasir K.
The homeostasis model assessment of insulin resistance has a positive and graded association with extra-coronary calcification, but not independently of cardiovascular risk factors, particularly metabolic syndrome components.
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The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis.
By: Tison GH, Blaha MJ, Budoff MJ, Katz R, Rivera JJ, Bertoni AG, Wong ND, Blumenthal RS, Szklo M, Eng J, Tracy R, Nasir K.
We hypothesized that insulin resistance, measured by the homeostasis model assessment of insulin resistance (HOMA-IR), is independently associated with prevalent and incident extra-coronary calcification (ECC). We concluded that HOMA has a positive and graded association with ECC, but not independently of cardiovascular risk factors, particularly metabolic syndrome components.
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Metabolically benign obesity: a wolf in sheep’s clothing.
By: McEvoy JW, Blaha MJ, Nasir K.
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The relationship between resting heart rate and incidence and progression of coronary artery calcification: The multi-ethnic study of atherosclerosis (MESA).
By: Rubin J, Blaha MJ, Budoff MJ, Rivera JJ, Shaw LJ, Blankstein R, Mallah MA, Carr JJ, Jones DL, Blumenthal RS, Nasir K.
Elevated resting heart rate has been independently associated with cardiovascular and all-cause mortality. The pathophysiological mechanisms by which this increased risk occurs are unclear. We hypothesized that elevated resting heart rate would be associated with increased development of atherosclerosis, as assessed by the incidence and progression of CAC. We concluded that elevated resting heart rate, a well-described predictor of cardiovascular mortality with unclear mechanism, is associated with increased incidence and progression of coronary atherosclerosis among individuals free of CVD at baseline.
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Thoracic aortic calcification and coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA).
By: Budoff MJ, Nasir K, Katz R, Takasu J, Carr JJ, Wong ND, Allison M, Lima JA, Detrano R, Blumenthal RS, Kronmal R.
The presence and extent of CAC is an independent predictor of CHD morbidity and mortality. Few studies have evaluated interactions or independent incremental risk for coronary and thoracic aortic calcification (TAC). The independent predictive value of TAC for CHD events is not well-established. This study used risk factor and computed tomography scan data from 6,807 participants in MESA. Using the same images for each participant, TAC and CAC were each computed using the Agatston method. Our study indicates that TAC is a significant predictor of future coronary events only in women, independent of CAC. On studies obtained for either cardiac or lung applications, determination of TAC may provide modest supplementary prognostic information in women with no extra cost or radiation.
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By: Differences in coronary plaque composition by noninvasive computed tomography angiography in individuals with and without obstructive coronary artery disease.
CCTA has emerged as a promising non-invasive tool to detect CAD, which provides additional information about atherosclerotic plaque composition. We assessed whether differences in plaque composition and plaque burden exist across patients with more advanced as well as <50% coronary stenosis. Plaque composition is different according to severity of CAD with a higher mixed plaque and lesser non-calcified plaque burden among those patients with ?50% stenotic CAD. These findings should stimulate further investigations to assess the prognostic value of coronary plaque subtypes according to their underlying composition.
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