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Ciccarone Articles

Ciccarone Center Research

Year

2012

Landmark Articles

Cardiovascular effects of noninsulin, glucose-lowering agents: Need for more outcomes data.
By: Joshi PH, Kalyani RR, Blumenthal RS, Donner TW.
This comprehensive review article provides recommendations, based on current data, for a therapeutic approach with noninsulin, glucose-lowering agents for the prevention of cardiovascular events in patients with type 2 diabetes.
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Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
By: Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Post WS, et al.
This large meta-analysis of lipid phenotypes with the use of a dense gene-centric approach identified multiple single nucleotide polymorphisms not previously described in established lipid genes and several previously unknown loci, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
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Let’s not be so quick to stop statins: Expert opinion on the importance of awareness of reporting bias and outstanding questions in studies.
By: Martin SS, Blaha MJ, Blumenthal RS.
Researchers examined a study linking statins to fatigue and found that it lacked several elements expected of a high-quality randomized controlled trial and suffered from multiple potential sources of bias.
Apolipoproteins do not add prognostic information beyond lipoprotein cholesterol measures among individuals with obesity and insulin resistance syndromes: The ARIC Study.
By: Ndumele CE, Matsushita K, Astor B, Virani SS, Mora S, Williams EK, Hoogeveen RC, Blumenthal RS, Sharrett AR, Ballantyne CM, Coresh J.
Among individuals with obesity and insulin resistance syndromes, apolipoproteins did not provide prognostic information regarding CHD risk beyond that provided by non-HDL-C and HDL-C.
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Dyslipidemia management for secondary prevention in women with cardiovascular disease: What can we expect from non-pharmacologic strategies?
By: Whelton S, Chow GV, Ashen MD, Blumenthal RS.

In this review, we examine the effect of non-pharmacologic therapy (i.e., diet and lifestyle modification) on lipids as part of the secondary prevention strategy of cardiovascular disease in women.

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Cigarette smoking is associated with increased mortality in both the presence and absence of coronary artery calcification.
By: McEvoy JW, Blaha MJ, Rivera JJ, Budoff MJ, Khan AN, Shaw LJ, Berman DS, Raggi P, Min JK, Rumberger JA, Callister TQ, Blumenthal RS, Nasir K.

The aim of this study was to further explore the interplay between smoking status, coronary artery calcium (CAC), and all-cause mortality. Smoking is a risk factor for death across the entire spectrum of subclinical coronary atherosclerosis. Smokers with any CAC had significantly higher mortality than smokers without CAC, a finding with implications for smokers undergoing lung cancer CT-based screening. However, the absence of CAC might not be as useful a "negative risk factor" in active smokers, because this group has mortality rates similar to nonsmokers with mild-to-moderate atherosclerosis.

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Mitochondrial performance in heat acclimation—a lesson from ischemia/reperfusion and calcium overload insults in the heart.
By: Assayag M, Saada A, Gerstenblith G, Canaana H, Shlomai R, Horowitz M.

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Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification.
By: McEvoy JW, Blaha MJ, Rivera JJ, Budoff MJ, Khan AN, Shaw LJ, Berman DS, Raggi P, Min JK, Rumberger JA, Callister TQ, Blumenthal RS, Nasir K.

The aim of this study was to further explore the interplay between smoking status, coronary artery calcium (CAC), and all-cause mortality. Smoking is a risk factor for death across the entire spectrum of subclinical coronary atherosclerosis. Smokers with any CAC had significantly higher mortality than smokers without CAC, a finding with implications for smokers undergoing lung cancer CT-based screening. However, the absence of CAC might not be as useful a "negative risk factor" in active smokers, because this group has mortality rates similar to nonsmokers with mild-to-moderate atherosclerosis.

Read on Pubmed
Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptors.
By: McLean RC, Baird SW, Becker LC, Townsend SN, Gerstenblith G, Kass DA, Tomaselli GF, Schulman SP.
This study concludes that beta receptor gene variants significantly influence inotropic and chronotropic responses to beta-agonist exposure in patients on beta blocker therapy.
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Use of high-sensitivity C-reactive protein for risk assessment.
By: Graham G, Ketlogetswe KS, Campbell CY, Musunuru K, Mora S, Blumenthal RS.