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Ciccarone Articles

Ciccarone Center Research


Vascular Imaging

Landmark Article

Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis.
By: Tota-Maharaj R, Blaha MJ, Zeb I, Katz R, Blankstein R, Blumenthal RS, Budoff MJ, Nasir K.
African-Americans have a lower prevalence, and Hispanics have a higher prevalence, of fatty liver than do other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even in patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a substantial role in the phenotypic expression of fatty liver.
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Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA).
By: Linefsky JP, O’Brien KD, Sachs M, Katz R, Eng J, Michos ED, Budoff MJ, de Boer I, Kestenbaum B.
Data indicate that serum phosphate levels are significantly associated with aortic valve calcification prevalence.
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Myocardial steatosis and its association with obesity and regional ventricular dysfunction: evaluated by magnetic resonance tagging and 1H spectroscopy in healthy African Americans.
By: Liu CY, Bluemke DA, Gerstenblith G, Zimmerman SL, Li J, Zhu H, Lai S, Lai H.
This study found no relationship between cardiac steatosis and left ventricular volumes or ejection fraction, though there is some evidence suggesting that cardiac steatosis may be associated with LV regional function in healthy African-American women.
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Reproducibility of measurements by multi-detector computed tomography: Intra- and inter-reader measures for epicardial and intra-thoracic adipose tissue.
By: Rezaeian P, Razipour A, Li D, Zeb I, Baskett M, Post WS, Budoff MJ.
Statin use is not associated with presence of and severity of nonalcoholic fatty liver disease.
By: Oni ET, Sinha P, Karim A, Martin SS, Blaha MJ, Agatston AS, Blumenthal RS, Meneghelo RS, Conceiçao RD, Santos RD, Nasir K.
These results favor statin use in subjects with nonalcoholic fatty liver disease, since its use is not associated with the presence of the disease or increased fibrosis.
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Relation of thoracic aortic distensibility to left ventricular area (from the Multi-Ethnic Study of Atherosclerosis [MESA]).
By: Al-Mallah MH, Nasir K, Katz R, Lima JA, Bluemke DA, Blumenthal RS, Mao S, Hundley WG, Budoff MJ.
The aim of this study was to test the hypothesis that decreasing aortic compliance and increasing arterial stiffness are independently associated with increased left ventricular area.
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Response to importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness.
By: Whelton SP, Blaha MJ.
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Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events.
By: Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, Lawler MA, Grinspoon SK, Brady TJ, Nasir K, Hoffmann U, Tawakol A.

Arterial fluorodeoxyglucose, measured from routinely obtained PET/CT images, substantially improved incident CVD prediction beyond Framingham risk score among individuals undergoing cancer surveillance.

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A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?
By: Oni ET, Agatston AS, Blaha MJ, Fialkow J, Cury R, Sposito A, Erbel R, Blankstein R, Feldman T, Al-Mallah MH, Santos RD, Budoff MJ, Nasir K.

Considerable evidence supports the association of nonalcoholic fatty liver disease with subclinical atherosclerosis, independent of traditional risk factors and metabolic syndrome.

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Relation of hepatic steatosis to atherogenic dyslipidemia.
By: Makadia S, Blaha MJ, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin SS, Kohli P, Conceicao RD, Carvalho JA, Nasir K, Blumenthal RS, Santos R.
This article looks at the relationship between fatty liver and atherogenic lipid profiles.
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