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Ciccarone Center Research
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Nutrition, Vitamins, Supplements
Relation of hepatic steatosis to atherogenic dyslipidemia.
Hepatic steatosis may play a direct metabolic role in conferring increased cardiovascular risk.
25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis.
The consistent lack of association of vitamin D and parathyroid hormone with carotid intima-media thickness and plaque suggests that these hormones may influence cardiovascular risk through pathways not reflected by carotid atherosclerosis.
25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the Multi-Ethnic Study of Atherosclerosis.
This study shows that the consistent lack of association of vitamin D and parathyroid hormone with carotid intima-media thickness and plaque suggests that these hormones may influence cardiovascular risk through pathways not reflected by carotid atherosclerosis.
Vitamin D, calcium, and atherosclerotic risk: evidence from serum levels and supplementation studies.
This review summarizes evidence of the relationship between vitamin D, calcium supplements, and cardiovascular disease, and comments on the recent Institute of Medicine recommendations regarding use of these nutrients.
Vitamin D deficiency is associated with silent coronary artery disease in cardiovascularly asymptomatic African-Americans with HIV infection.
Both vitamin D deficiency and silent CAD are prevalent in HIV-infected African-Americans. In addition to management of traditional CAD risk factors and substance abuse, vitamin D deficiency should be evaluated in HIV-infected African-Americans. These data support the conduct of a prospective trial of vitamin D in this high-risk patient population.
Vitamin D deficiency is associated with the development of subclinical coronary artery disease in African-Americans with HIV infection: a preliminary study.
The incidence of subclinical CAD in African-Americans with HIV infection is provocatively high. Larger studies are warranted to confirm the role of vitamin D deficiency in the development of CAD in HIV-infected African-Americans.
25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES-III linked mortality files.
Deficient 25-hydroxyvitamin D (25[OH]D) levels are associated with cardiovascular disease (CVD) events and mortality. 25(OH)D deficiency and stroke are more prevalent in blacks. We examined whether low 25(OH)D contributes to the excess risk of fatal stroke in blacks compared with whites. Vitamin D deficiency was associated with an increased risk of stroke death in whites but not in blacks. Although blacks had a higher rate of fatal stroke compared with whites, the low 25(OH)D levels in blacks were unrelated to stroke incidence. Therefore 25(OH)D levels did not explain this excess risk.
Serum 25-hydroxyvitamin D, calcium, phosphorus, and electrocardiographic QT interval duration: findings from NHANES III and ARIC.
Disturbances in 25-hydroxyvitamin D, calcium, and phosphorus concentrations have been associated with increased risks of total and cardiovascular mortality. It is possible that changes in electrocardiographic QT interval duration may mediate these effects, but the association of 25-hydroxyvitamin D, phosphorus, and calcium concentrations with QT interval duration has not been evaluated in general population samples. The objective of the study was to evaluate the association of 25-hydroxyvitamin D, phosphorus, and calcium concentrations with QT interval duration in two large samples of the U.S. population. QT interval duration was inversely associated with the serum total and ionized calcium and positively associated with serum phosphorus.