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Ciccarone Articles

Ciccarone Center Research

Topic

Heart Rate

Electrocardiographic and clinical predictors separating atherosclerotic sudden cardiac death from incident coronary heart disease.
By: Soliman EZ, Prineas RJ, Case LD, Russell G, Rosamond W, Rea T, Sotoodehnia N, Post WS, Siscovick D, Psaty BM, Burke GL.
Sudden cardiac death and coronary heart disease have many risk factors in common, including hypertension, race/ethnicity, BMI, and heart rate, that have the potential to separate between the risks of both diseases. These results need to be validated in another cohort.
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The relationship between resting heart rate and incidence and progression of coronary artery calcification: The multi-ethnic study of atherosclerosis (MESA).
By: Rubin J, Blaha MJ, Budoff MJ, Rivera JJ, Shaw LJ, Blankstein R, Mallah MA, Carr JJ, Jones DL, Blumenthal RS, Nasir K.
Elevated resting heart rate has been independently associated with cardiovascular and all-cause mortality. The pathophysiological mechanisms by which this increased risk occurs are unclear. We hypothesized that elevated resting heart rate would be associated with increased development of atherosclerosis, as assessed by the incidence and progression of CAC. We concluded that elevated resting heart rate, a well-described predictor of cardiovascular mortality with unclear mechanism, is associated with increased incidence and progression of coronary atherosclerosis among individuals free of CVD at baseline.
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Localized calcific constrictive pericarditis masquerading as a basal aneurysm.
By: Blaha MJ, Panjrath G, Chacko M, Schulman SP.
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Statin therapy in the prevention and treatment of atrial fibrillation.
By: Lee YL, Blaha MJ, Jones SR.
Atrial fibrillation (AF) is the most common adult rhythm disorder, and it is associated with a substantial rate of morbidity and economic burden. There is an increasing body of literature in which the authors investigated the pleiotropic effects of statin therapy in relation to AF. Its utility in patients with paroxysmal AF may be limited to the prevention of incident AF, but it does not appear to inhibit the progression of paroxysmal AF to chronic AF. Further large scale, randomized, placebo-controlled studies are needed in perioperative use in noncardiac surgery and in patients undergoing ablation or cardioversion of AF.
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