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Ciccarone Articles

Ciccarone Center Research

Journal

Atherosclerosis

A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?
By: Oni ET, Agatston AS, Blaha MJ, Fialkow J, Cury R, Sposito A, Erbel R, Blankstein R, Feldman T, Al-Mallah MH, Santos RD, Budoff MJ, Nasir K.

Considerable evidence supports the association of nonalcoholic fatty liver disease with subclinical atherosclerosis, independent of traditional risk factors and metabolic syndrome.

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No association of 9p21 with arterial elasticity and retinal microvascular findings.
By: Folsom AR, Pankow JS, Li X, Duprez DA, Jacobs DR Jr, Klein R, Klein B, Tang W, Wong TY, Cotch MF, Taylor KD, Rich SS, Hall JL, Post WS, Rotter JI.
This study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.
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Absolute coronary artery calcium score is the best predictor of non-calcified plaque involvement in patients with low calcium scores (1–100).
By: Tam LM, Joonseok K, Blumenthal RS, Nasir K, Al-Mallah MH, Blaha MJ.
This study looked at the predictors on non-calcified plaque in persons with mild coronary calcification.
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Discordance: Can we capitalize on it to better personalize atherosclerosis treatment?
By: Nasir K, Martin SS, Virani S.
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Family history of coronary heart disease (CHD) and markers of subclinical cardiovascular disease: Where do we stand?
By: Pandey AK, Pandey S, Blaha MJ, Agatston A, Feldman T, Ozner M, Santos RD, Budoff MJ, Blumenthal RS, Nasir K.
Family history of coronary artery disease is associated with markers of subclinical atherosclerosis, and this relationship remains statistically significant after adjusting for traditional risk factors. Our data suggest these individuals should be considered strongly as candidates for assessment of subclinical CVD to further refine risk and treatment goals.
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Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis.
By: DeFilippis AP, Blaha MJ, Martin SS, Reed RM, Jones SR, Nasir K, Blumenthal RS, Budoff MJ.
This study found that, after adjustment for multiple metabolic risk factors, adiposity, and measures of insulin resistance, there may be a link between nonalcoholic fatty liver disease and dyslipidemia.
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Impact of coronary artery calcification on all-cause mortality in individuals with and without hypertension.
By: Graham G, Blaha MJ, Budoff MJ, Rivera JJ, Agatston A, Raggi P, Shaw LJ, Berman D, Rana JS, Callister T, Rumberger JA, Min J, Blumenthal RS, Nasir K.
This study found that the addition of CAC scores contributed significantly in predicting mortality, in addition to traditional risk factors alone, among those with and without hypertension.
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Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study.
By: Hechter RC, Budoff M, Hodis HN, Rinaldo CR, Jenkins FJ, Jacobson LP, Kingsley LA, Taiwo B, Post WS, Margolick JB, Detels R.

We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR]=4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI=1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.

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Association between traditional cholesterol parameters, lipoprotein particle concentration, novel biomarkers and carotid plaques in retired National Football League players.
By: Virani SS, Pompeii L, Lincoln AE, Dunn RE, Tucker AM, Nambi V, Nasir K, Vogel RA, Boone JL, Roberts AJ, Ballantyne CM.

We assessed whether low-density lipoprotein particle concentration (LDL-P) and high-sensitivity C-reactive protein [hs-CRP] can identify subclinical atherosclerosis better than traditional cholesterol parameters in retired National Football League (NFL) players. Carotid artery plaques were common in retired NFL players and were strongly associated with LDL-P, especially among those with metabolic syndrome. hs-CRP was not associated with carotid plaques in this cohort.

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The relationship between resting heart rate and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA).
By: Rubin J, Blaha MJ, Budoff MJ, Rivera JJ, Shaw LJ, Blankstein R, Mallah MA, Carr JJ, Jones DL, Blumenthal RS, Nasir K.
We conclude that elevated resting heart rate, a well-described predictor of cardiovascular mortality with unclear mechanism, is associated with increased incidence and progression of coronary atherosclerosis among individuals free of CVD at baseline.
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