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Ciccarone Articles

Ciccarone Center Research

Journal

American Journal of Cardiology

Landmark Articles

  • This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
    Read on Pubmed
  • Much attention has been directed toward lifestyle modifications as effective means of reducing cardiovascular disease risk. We review recent observational and interventional trials investigating the effects of physical activity on markers of (or causal factors for) atherosclerotic burden and vascular disease. There is a strong correlation between physical activity and triglyceride reduction, apolipoprotein B reduction, HDL increase, change in LDL particle size, increase in tissue plasminogen activator activity, and decrease in CAC. Further research is needed to elucidate the effect on inflammatory markers and intima-media thickness.
    Read on Pubmed
Impact of fitness versus obesity on routinely measured cardiometabolic risk in young, healthy adults.
By: Vranian MN, Keenan T, Blaha MJ, Silverman MG, Michos ED, Minder CM, Blumenthal RS, Nasir K, Meneghelo RS, Santos RD.
Although fitness and obesity are independently associated with cardiometabolic risk, and their effects are additive, obesity is more strongly associated with this risk when fitness and obesity are discordant. These findings underscore the need for weight loss in obese patients and suggest an unmeasured benefit of fitness.
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Relation of uric acid to serum levels of high-sensitivity C-reactive protein, triglycerides, and high-density lipoprotein cholesterol and to hepatic steatosis.
By: Keenan T, Blaha MJ, Nasir K, Silverman MG, Tota-Maharaj R, Carvalho JA, Conceição RD, Blumenthal RS, Santos RD.
High uric acid levels were associated with increased triglycerides, high-density lipoprotein cholesterol, and hepatic steatosis, independent of metabolic syndrome and obesity, and with increased hsCRP independently of metabolic syndrome.
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Cardiovascular effects of noninsulin, glucose-lowering agents: Need for more outcomes data.
By: Joshi PH, Kalyani RR, Blumenthal RS, Donner TW.
This comprehensive review article provides recommendations, based on current data, for a therapeutic approach with noninsulin, glucose-lowering agents for the prevention of cardiovascular events in patients with type 2 diabetes.
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Response to catecholamine stimulation of polymorphisms of the beta-1 and beta-2 adrenergic receptors.
By: McLean RC, Baird SW, Becker LC, Townsend SN, Gerstenblith G, Kass DA, Tomaselli GF, Schulman SP.
This study concludes that beta receptor gene variants significantly influence inotropic and chronotropic responses to beta-agonist exposure in patients on beta blocker therapy.
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Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the Meantime, Some Challenges and Recommendations.
By: Martin SS, Metkus TS, Horne A, Blaha MJ, Hasan R, Campbell CY, Yousuf O, Joshi P, Kaul S, Miller M, Michos ED, Jones SR, Gluckman TJ, Cannon CP, Sperling LS, Blumenthal RS.
The National Cholesterol Education Program Adult Treatment Panel (ATP) has provided education and guidance for decades on the management of hypercholesterolemia. Its third report (ATP III) was published 10 years ago, with a white paper update in 2004. There is a need for translation of more recent evidence into a revised guideline. To help address the significant challenges facing the ATP IV writing group, this statement aims to increase the likelihood of implementation in clinical practice by offering solutions that translate the totality of published reports into enhanced hyperlipidemia guidelines to better combat the devastating impact of hyperlipidemia on cardiovascular health.
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A national interactive Web-based physical activity intervention in women, evaluation of the American Heart Association Choose to Move program 2006-2007.
By: Lieber SB, Redberg RF, Blumenthal RS, Gandhi A, Robb KJ, Mora S.
In this national cohort of women, a 12-week Web-based intervention improved physical activity and quality of life measurements, resulting in higher short-term physical activity guideline compliance and better quality of life. Increasing use of this simple Web-based tool could improve physical activity and promote disease prevention.
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Comparative value of coronary artery calcium and multiple blood biomarkers for prognostication of cardiovascular events.
By: Rana JS, Gransar H, Wong ND, Shaw L, Pencina M, Nasir K, Rozanski A, Hayes SW, Thomson LE, Friedman JD, Min JK, Berman DS.
In this study of asymptomatic subjects without known CVD, the addition of CAC but not biomarkers substantially improved risk reclassification for future CVD events beyond traditional risk factors.
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Comparison of the Diamond-Forrester method and Duke Clinical Score to predict obstructive coronary artery disease by computed tomographic angiography.
By: Wasfy MM, Brady TJ, Abbara S, Nasir K, Ghoshhajra BB, Truong QA, Hoffmann U, Di Carli MF, Blankstein R.

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Read on Pubmed
Effects of physical activity on cardiovascular disease.
By: Ahmed HM, Blaha MJ, Nasir K, Rivera JJ, Blumenthal RS.
Much attention has been directed toward lifestyle modifications as effective means of reducing cardiovascular disease risk. We review recent observational and interventional trials investigating the effects of physical activity on markers of (or causal factors for) atherosclerotic burden and vascular disease. There is a strong correlation between physical activity and triglyceride reduction, apolipoprotein B reduction, HDL increase, change in LDL particle size, increase in tissue plasminogen activator activity, and decrease in CAC. Further research is needed to elucidate the effect on inflammatory markers and intima-media thickness.
Read on Pubmed
Effects of physical activity on cardiovascular disease.
By: Ahmed HM, Blaha MJ, Nasir K, Rivera JJ, Blumenthal RS.
This paper provides a comprehensive look at the benefits of increased physical activity on lipid changes, thrombotic, inflammatory factors, and measures of subclinical atherosclerosis.
Read on Pubmed