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Ciccarone Articles

Ciccarone Center Research

Journal

American Journal of Epidemiology

Landmark Article

Invited commentary: the association of low vitamin D with cardiovascular disease — getting at the “heart and soul” of the relationship.
By: Schneider AL, Michos ED.
The authors place the results from the Heart and Soul study in context with the existing literature and propose future directions for vitamin D research.
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Low-risk lifestyle, coronary calcium, cardiovascular events, and mortality: Results from MESA.
By: Ahmed HM, Blaha MJ, Nasir K, Jones SR, Rivera JJ, Agatston A, Blankstein R, Wong ND, Lakoski S, Budoff MJ, Burke GL, Sibley CT, Ouyang P, Blumenthal RS.
Unhealthy lifestyle habits are a major contributor to coronary artery disease (CAD). The purpose of the study was to investigate the associations of smoking, weight maintenance, physical activity, and Mediterranean-style diet with coronary calcium, cardiovascular events, and mortality. We discovered that, over the course of nearly 8 years, a combination of regular exercise, healthy diet, smoking avoidance, and weight maintenance contributed to lower coronary calcium incidence, slower calcium progression, and lower all-cause mortality.
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Sex-steroid hormones and electrocardiographic QT-interval duration: Findings from the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis.
By: Zhang Y, Ouyang P, Post WS, Dalal D, Vaidya D, Blasco-Colmenares E, Soliman EZ, Tomaselli GF, Guallar E.
The association between physiologic levels of sex hormones and QT-interval duration in humans was evaluated using data from 727 men enrolled in the Third National Health and Nutrition Examination Survey and 2,942 men and 1,885 postmenopausal women enrolled in MESA. Testosterone, estradiol, and sex hormone-binding globulin levels were measured in serum and free testosterone was calculated from those values. The findings suggest that testosterone levels may explain differences in QT-interval duration between men and women and could be a contributor to population variability in QT-interval duration among men.
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Sex differences in subclinical atherosclerosis by race/ethnicity in the multi-ethnic study of atherosclerosis.
By: Kim C, Diez-Roux AV, Nettleton JA, Polak JF, Post WS, Siscovick DS, Watson KE, Vahratian AM.
Sex differences in CVD mortality are more pronounced among non-Hispanic whites than other racial/ethnic groups, but it is unknown whether this variation is present in the earlier subclinical stages of disease. The authors examined racial/ethnic variation in sex differences in CAC and cIMT at baseline in 2000-2002 among participants (n = 6,726) in MESA using binomial and linear regression. Models adjusted for risk factors in several stages: age, traditional cardiovascular disease risk factors, behavioral risk factors, psychosocial factors, and adult socioeconomic position. In conclusion, coronary artery calcification is differentially patterned by sex across racial/ethnic groups.
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Association of left ventricular hypertrophy with incident hypertension: the multi-ethnic study of atherosclerosis.
By: Shimbo D, Muntner P, Mann D, Barr RG, Tang W, Post W, Lima J, Burke G, Bluemke D, Shea S.
Increased LV mass and changes in LV geometry may precede hypertension onset. The authors examined the associations of LV mass and geometry, assessed by cardiac magnetic resonance imaging, with hypertension incidence in 2,567 normotensive participants enrolled in 2000-2002 in MESA. Higher levels of LV concentric geometry, defined by higher LV mass to end-diastolic volume quartiles, were associated with higher risk of incident hypertension in a fully adjusted model. In a final model containing both quartiles of LV mass and LV mass/volume, along with all covariates including baseline blood pressure, higher LV mass quartiles were associated with incident hypertension, whereas higher LV mass/volume quartiles were not. In this multiethnic cohort, alterations in LV mass preceded hypertension onset among normotensive individuals.
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Sex steroid hormone concentrations and risk of death in U.S. men.
By: Menke A, Guallar E, Rohrmann S, Nelson WG, Rifai N, Kanarek N, Feinleib M, Michos ED, Dobs A, Platz EA.
Men with low free and bioavailable testosterone levels may have a higher risk of mortality within 9 years of hormone measurement. Future studies should be conducted to fully characterize the association of low free and bioavailable testosterone concentrations and mortality in men and to describe the mechanism underlying the association.
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