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Ciccarone Articles

Ciccarone Center Research

Journal

American Journal of Cardiology

Landmark Articles

  • This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
    Read on Pubmed
  • Much attention has been directed toward lifestyle modifications as effective means of reducing cardiovascular disease risk. We review recent observational and interventional trials investigating the effects of physical activity on markers of (or causal factors for) atherosclerotic burden and vascular disease. There is a strong correlation between physical activity and triglyceride reduction, apolipoprotein B reduction, HDL increase, change in LDL particle size, increase in tissue plasminogen activator activity, and decrease in CAC. Further research is needed to elucidate the effect on inflammatory markers and intima-media thickness.
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Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter AIDS Cohort Study.
By: Miller PE, Budoff M, Zikusoka M, Li X, Palella F Jr, Kingsley LA, Witt MD, Sharrett AR, Jacobson LP, Post WS.
The lower prevalence of CAC in black men compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
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Comparison of the relation between left ventricular anatomy and QRS duration in patients with cardiomyopathy with versus without left bundle branch block.
By: Chan DD, Wu KC, Loring Z, Galeotti L, Gerstenblith G, Tomaselli G, Weiss RG, Wagner GS, Strauss DG.
Increasing left ventricular (LV) anatomical measurements were associated with increasing QRS duration in patients with cardiomyopathy.
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Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.
By: Ratchford EV, Carson KA, Jones SR, Ashen MD.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.
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Risk and the physics of clinical prediction.
By: McEvoy JW, Diamond GA, Detrano RC, Kaul S, Blaha MJ, Blumenthal RS, Jones SR.
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
Read on Pubmed
Relation between self-reported physical activity level, fitness, and cardiometabolic risk.
By: Minder CM, Shaya GE, Michos ED, Keenan TE, Blumenthal RS, Nasir K, Carvalho JA, Conceição RD, Santos RD, Blaha MJ.
Self-reported physical activity level and directly measured fitness are moderately correlated, and the latter is more strongly associated with a protective cardiovascular risk profile.
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Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen): from the Multi-Ethnic Study of Atherosclerosis.
By: Whelton SP, Narla V, Blaha MJ, Nasir K, Blumenthal RS, Jenny NS, Al-Mallah MH, Michos ED.
Heart rate (HR) at rest is associated with adverse cardiovascular events; however, the biologic mechanism for the relation is unclear. An increased HR at rest was associated with a higher level of inflammation among an ethnically diverse group of subjects without known cardiovascular disease.
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Relation of thoracic aortic distensibility to left ventricular area (from the Multi-Ethnic Study of Atherosclerosis [MESA]).
By: Al-Mallah MH, Nasir K, Katz R, Lima JA, Bluemke DA, Blumenthal RS, Mao S, Hundley WG, Budoff MJ.
The aim of this study was to test the hypothesis that decreasing aortic compliance and increasing arterial stiffness are independently associated with increased left ventricular area.
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Relation of hepatic steatosis to atherogenic dyslipidemia.
By: Makadia SS, Blaha M, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin S, Kohli P, Conceicao R, Carvalho J, Nasir K, Blumenthal R, Santos RD.
Hepatic steatosis may play a direct metabolic role in conferring increased cardiovascular risk.
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Relation of hepatic steatosis to atherogenic dyslipidemia.
By: Makadia S, Blaha MJ, Keenan T, Ndumele C, Jones S, DeFilippis A, Martin SS, Kohli P, Conceicao RD, Carvalho JA, Nasir K, Blumenthal RS, Santos R.
This article looks at the relationship between fatty liver and atherogenic lipid profiles.
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Effect of equivalent on-treatment apolipoprotein levels on outcomes (from the AIM-HIGH and HPS2-THRIVE).
By: Al-Hijji M, Martin SS, Joshi PH, Jones SR.

This viewpoint study seeks to explore the recent failures of the niacin trials through apolipoprotein lens.

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