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Ciccarone Center Research
View by Topic
- Antiplatelet Therapy
- ASCVD (Atherosclerotic Cardiovascular Disease)
- Blood Pressure
- Cardiac CT
- Cardiovascular Risk Assessment
- Carotid Atherosclerosis
- Cerebrovascular Disease / Stroke / Cognitive Function
- Cholesterol / Lipids / Statins
- Cigarette Smoking
- Diabetes & Metabolic Syndrome
- Diet & Weight
- Disparities in Care
- Emotional Health
- Endothelial Function
- Erectile Dysfunction
- Exercise and Physical Fitness
- Family History of CVD
- Gender / Cardiovascular Disease in Women
- Heart Failure
- Heart Rate
- Markers of Thrombosis, Myocardial Injury, Wall Stress
- Mobile Health
- Nutrition, Vitamins, Supplements
- PVD – Peripheral Vascular Disease
- Quality of Care
- Renal Disease
- Rheumatoid Arthritis & Collagen Vascular Diseases
- Sleep Disorders
- Stem Cells
- Subclinical Atherosclerosis
- Vascular Imaging
- Vascular Stiffness
View by Journal
- American Heart Journal
- American Journal of Cardiology
- American Journal of Epidemiology
- American Journal of Hypertension
- Annals of Internal Medicine
- Arteriosclerosis, Thrombosis & Vascular Biology
- British Medical Journal
- Clinical Cardiology
- Diabetes Care
- European Heart Journal
- European Journal of Preventive Cardiology
- International Journal of Cardiology
- Journal of Hypertension
- Journal of the American College of Cardiology
- Journal of the American Heart Association
- Journal of the American Medical Association
- Mayo Clinic Proceedings
- New England Journal of Medicine
- PLoS One
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- Meet the Authors
All Ciccarone Research Articles
Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb.
Common carotid artery intima-media thickness (IMT) measurements made below the carotid bulb are smaller but have more consistent associations with CHD risk factors and outcomes compared with IMT measured near the bulb.
Associations of Pentraxin 3 with cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis.
In a study of apparently healthy adults, Pentraxin 3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of C-reactive protein (CRP) and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis.
CPAP versus oxygen in obstructive sleep apnea.
In patients with cardiovascular disease or multiple CVD risk factors, the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP), but not nocturnal supplemental oxygen, resulted in a significant reduction in blood pressure.
Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the atherosclerosis risk in communities study.
High levels of serum FGF-23 were associated with increased risk of coronary heart disease, heart failure, and cardiovascular mortality in this large, biracial, population-based cohort.
Understanding the high prevalence of diabetes in U.S. South Asians compared with four racial/ethnic groups: The MASALA and MESA Studies.
This study compared South Asians with four other racial/ethnic groups in the U.S. to determine whether socio-demographic, lifestyle, or metabolic factors could explain the higher diabetes prevalence and whether insulin resistance and beta-cell dysfunction occurred at younger ages and/or lower adiposity levels compared with other groups.
Invited commentary: the association of low vitamin D with cardiovascular disease — getting at the “heart and soul” of the relationship.
The authors place the results from the Heart and Soul study in context with the existing literature and propose future directions for vitamin D research.
Vascular disease patient information page: Peripheral artery disease.
Peripheral artery disease is common, and the symptoms typically include leg discomfort with exercise. Patients with PAD can also have other symptoms such as non-healing wounds on the feet. A simple ABI test with a blood pressure cuff can diagnose PAD. Treatment for PAD includes smoking cessation, medications aimed at preventing heart attack and stroke, and exercise to alleviate the discomfort. Patients with more severe PAD, such as those with wounds that are not healing or those with symptoms that do not respond to medication and exercise, may need to undergo a procedure to restore blood flow to the leg (angioplasty or bypass surgery).
Vulnerability of the developing heart to oxygen deprivation as a cause of congenital heart defects.
Low oxygen concentrations and lack of oxygen reserve during a critical phase of heart organogenesis may provide a basis for vulnerability to the development of common septation and conotruncal heart defects.
Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?
Among overweight women with dysglycemia, the magnitude of blood pressure reductions after intensive lifestyle change is unrelated to postmenopausal estrogen use.
Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.
This study of late middle age white and black participants did not find significant associations between lower levels of 25-hydroxy vitamin D with lower cognitive test scores at baseline, change in scores over time or dementia risk.
The fascinating story of PCSK9 Inhibition: Insights and perspective from ACC.14.
The development of PCSK9 inhibitors is coming along at a unique point in the realm of preventive cardiology from multiple perspectives.
Risk factors for fatty liver in the Multicenter AIDS Cohort Study.
Though treated HIV infection was associated with a lower prevalence of fatty liver, prolonged exposure to dideoxynucleoside analogs is associated with higher prevalence.Read on Pubmed
Comparison of the relation between left ventricular anatomy and QRS duration in patients with cardiomyopathy with versus without left bundle branch block.
Increasing left ventricular (LV) anatomical measurements were associated with increasing QRS duration in patients with cardiomyopathy.
Diabetes and depression.
Both psychological interventions and antidepressants are effective in treating depressive symptoms in people with diabetes but have mixed effects on glycemic control.
Vascular disease patient information page: Venous Thromboembolism (deep vein thrombosis and pulmonary embolism).
Venous thromboembolism is common, occurring in about one to two per 1000 people each year. DVT is typically diagnosed using ultrasound. PE is usually diagnosed using a CT scan. Anticoagulant medications are the mainstay of treatment; most patients take anticoagulants for a minimum of 3 months. Several important measures can help prevent venous thromboembolism.
Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.
A high burden of subclinical coronary atherosclerosis in South Asians may partly explain higher rates of cardiovascular disease in South Asians.
Nonfatal outcomes in the primary prevention of atherosclerotic cardiovascular disease: is all-cause mortality really all that matters?
This article clearly shows that major nonfatal cardiovascular outcomes are very important to take into account when designing primary prevention guidelines.
Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis.
Greater epicardial fat volume in HIV-infected men and its association with coronary plaque and antiretroviral therapy duration suggest potential mechanisms that might lead to increased risk for cardiovascular disease in HIV.
Use of coronary artery calcium testing to guide aspirin utilization for primary prevention: estimates from the multi-ethnic study of atherosclerosis.
For the primary prevention of coronary heart disease (CHD), MESA participants with coronary artery calcium (CAC) ?100 were shown to have favorable risk/benefit estimations for aspirin use, while participants with zero CAC were estimated to receive net harm from aspirin.
Baseline subclinical atherosclerosis burden and distribution are associated with frequency and mode of future coronary revascularization: multi-ethnic study of atherosclerosis.
There was a strong association between the baseline burden and regional distribution of CAC and the risk and type of future coronary revascularization among asymptomatic subjects.
Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness.
Though common carotid IMT is not associated with stroke, inter-adventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT.
Does hormone therapy affect blood pressure in the Diabetes Prevention Program?
This study aims to examine whether blood pressure reductions differ by estrogen use among overweight glucose-intolerant women. Among overweight women with dysglycemia, the magnitude of blood pressure reductions after ILS is unrelated to postmenopausal estrogen use.
Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.
Delayed heart rate recovery is strongly associated with early and late stage prehypertension during exercise stress testing.
Among asymptomatic patients undergoing stress testing delayed HRR was independently associated with early and late stages of prehypertension. Further studies are needed to determine the usefulness of HRR measure in the prevention and management of hypertension.
Extensive bilateral lower extremity deep venous thrombosis in a patient on dimethyl fumarate.
We report a case of extensive bilateral lower extremity deep vein thrombosis (DVTs) in a patient recently started on dimethyl fumarate.
Insulin requirements in non-critically ill hospitalized diabetic patients with steroid-induced hyperglycemia.
Noncritically ill patients with hyperglycemia receiving steroids require a higher percentage of TDD insulin therapy as nutritional insulin to achieve normoglycemia.
Narrowing sex differences in lipoprotein cholesterol subclasses following mid-life: the very large database of lipids (VLDL-10B).
The narrowing sex differential in CVD risk after midlife is mirrored by a higher total atherogenic lipoprotein cholesterol burden in women and a closer approximation of the less favorable density phenotype characteristic of men.
- Journal: Journal of the American Heart Association
- Year: 2014
- Topics: Cholesterol / Lipids / Statins, Gender / Cardiovascular Disease in Women
- Read more articles by: Gary Gerstenblith, MD, Roger S. Blumenthal, MD, Michael Blaha, MD, MPH, Erin Michos, MD, MHS, Khurram Nasir, MD, MPH, Seth Martin, MD, MHS, Steven Jones, MD
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults.
The authors sought to answer five critical questions, addressing 1) expected health benefits of weight loss; 2) cut points for body mass index (BMI) and waist circumference; 3) dietary interventions most effective for weight loss; 4) the efficacy of a comprehensive lifestyle intervention programs; and 5) bariatric surgery.
Type 2 diabetes and cardiovascular disease: what next?
CVD in Type 2 diabetes is multifactorial and requires a multifaceted approach in reducing known cardiovascular risks, at both the individual patient and societal levels.
Screening low-risk individuals for coronary artery disease.
Data regarding the role of additional testing in low-risk populations to improve early detection or to enhance risk assessment indicate that CAC and the ankle-brachial index (ABI) may be helpful for improving risk classification and detecting the higher-risk people from among those at lower risk.
Fatty acids and TxA2 generation, in the absence of platelet-COX-1 activity.
This study shows that baseline omega-3 fatty acid levels do not influence TxA(2) generation in patients with or at high risk for CVD receiving adequate aspirin therapy.
Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis.
African-Americans have a lower prevalence, and Hispanics have a higher prevalence, of fatty liver than do other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even in patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a substantial role in the phenotypic expression of fatty liver.
Ten-year trends in coronary calcification in individuals without clinical cardiovascular disease in the multi-ethnic study of atherosclerosis.
Researchers reported a significant secular trend toward increased prevalence of CAC over 10 years among African-Americans and no change in three other ethnic groups..
Risk and the physics of clinical prediction.
This study shifts the focus from prediction of events to detection of disease in the effort to improve personalized decision-making and outcomes. It also discusses innovative future strategies for risk estimation and treatment allocation in preventive cardiology.
2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk.
The 2013 lifestyle guidelines provide guidance in three narrowly focused areas: 1) the effect of dietary patterns and macronutrient composition on CVD risk factors; 2) the effect of sodium and potassium on CVD risk factors; and 3) the effect of physical activity on blood pressure and lipids.
- Year: 2014
- Topics: ASCVD (Atherosclerotic Cardiovascular Disease), Blood Pressure, Cholesterol / Lipids / Statins, Cigarette Smoking, Diet & Weight, Exercise and Physical Fitness, Nutrition, Vitamins, Supplements, Cardiovascular Risk Assessment
- Read more articles by: Roger S. Blumenthal, MD, Seth Martin, MD, MHS
Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem...
Intramyocardial injection of autologous mesenchymal stem cells into akinetic yet nonrevascularized segments produces comprehensive regional functional restitution, which in turn drives improvement in global LV function.
Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally? An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.
Scar-size reduction and ventricular functional responses preferentially occurred at the sites of transendocardial stem cell injection, compared to nontransendocardial stem cell injection sites.
Delayed heart rate recovery is strongly associated with early and late-stage prehypertension during exercise stress testing.
Among asymptomatic patients undergoing stress testing, delayed heart rate recovery was independently associated with early and late stages of prehypertension.
Insulin requirements in non-critically ill hospitalized patients with diabetes and steroid-induced hyperglycemia.
Noncritically ill patients with hyperglycemia receiving steroids require a higher percentage of total daily dose insulin therapy as nutritional insulin to achieve normoglycemia.
Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
Elevated resting heart rate was associated with increased risk for incident HF in asymptomatic participants in the MESA trial; higher heart rate was related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA).
Data indicate that serum phosphate levels are significantly associated with aortic valve calcification prevalence.
Physical environment may modify the association between depressive symptoms and change in waist circumference: the multi-ethnic study of atherosclerosis.
Elevated depressive symptoms were associated with greater increase in waist circumference among individuals living in poorly rated physical environments than in those in better-rated physical environments.
Associations between HIV infection and subclinical coronary atherosclerosis.
Coronary artery plaque, especially noncalcified plaque, is more prevalent and extensive in HIV-infected men, independent of CAD risk factors.
Focused update on the 2013-2014 cardiovascular disease prevention guidelines.