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Wendy S. Post, MD, MS

Ciccarone Center Research

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Wendy S. Post, MD, MS

Wendy S. Post, MD, MS
Post, Wendy S., MD, MS

Wendy S. Post, MD, MS is a Professor of Medicine at the Johns Hopkins University, School of Medicine. She is also a Professor of Epidemiology at Johns Hopkins Bloomberg School of Public Health. Additionally she is part of the associate faculty at the Welch Center for Prevention and Clinical Research and Epidemiology divisions of Johns Hopkins University.

View my Johns Hopkins Medicine profile for more information and to request an appointment.

 

Landmark Articles

Methods for estimation of disparities in medication use in an observational cohort study: results from the Multi-Ethnic Study of Atherosclerosis.

By: McClelland RL, Jorgensen NW, Post WS, Szklo M, Kronmal RA.
Evaluating disparities in health care is an important aspect of understanding differences in disease risk. The purpose of this study is to describe the methodology for estimating such disparities, to provide improved disparity estimation in a large multi-ethnic cohort study.

Use of cardiac CT angiography imaging in an epidemiology study: the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy.

By: Hac?o?lu Y, Gupta M, Choi TY, George RT, Deible CR, Jacobson LP, Witt MD, Palella FJ, Post WS, Budoff MJ.
This study concluded that cardiac CT angiography may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low-risk populations while minimizing radiation exposure.
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Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey.

By: Zhang Y, Post WS, Cheng A, Blasco-Colmenares E, Tomaselli GF, Guallar E.
Variation in thyroid hormone levels in the general population, even within the normal range, was associated with various changes in electrocardiograms.
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Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.

By: Lewis JP, Ryan K, O’Connell JR, Horenstein RB, Damcott CM, Gibson Q, Pollin TI, Mitchell BD, Beitelshees AL, Pakzy R, Tanner K, Parsa A, Tantry US, Bliden KP, Post WS, Faraday N, Herzog W, Gong Y, Pepine CJ, Johnson JA, Gurbel PA, Shuldiner AR.
Common genetic variation in platelet endothelial aggregation receptor-1 may be a determinant of platelet response and cardiovascular events in patients on aspirin alone or in combination with clopidogrel.

Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity.

By: Frazier-Wood AC, Manichaikul A, Aslibekyan S, Borecki IB, Goff DC, Hopkins PN, Lai CQ, Ordovas JM, Post WS, Rich SS, Sale MM, Siscovick D, Straka RJ, Tiwari HK, Tsai MY, Rotter JI, Arnett DK.
Our findings suggest that the genetic underpinnings of mean lipoprotein diameter differ by race/ethnicity. As lipoprotein diameters are modifiable, this may lead new strategies to modify lipoprotein profiles during the reduction of insulin resistance that are sensitive to race/ethnicity.

Progression of coronary calcium and incident CHD events: MESA (Multi-Ethnic Study of Atherosclerosis).

By: Budoff MJ, Young R, Lopez VA, Kronmal RA, Nasir K, Blumenthal RS, Detrano RC, Bild DE, Guerci AD, Liu K, Shea S, Szklo M, Post W, Lima J, Bertoni A, Wong ND.
This study concluded that progression of coronary artery calcium (CAC) is associated with an increased risk for future heart disease events, even after controlling for other potentially confounding factors.

Genetic associations with valvular calcification and aortic stenosis.

By: Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O’Brien KD, Kamstrup PR, Nordestgaard BG, Tybjaerg-Hansen A, Allison MA, Aspelund T, Criqui MH, Heckbert SR, Hwang SJ, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V, O’Donnell CJ, Post WS; CHARGE Extracoronary Calcium Working Group.
Genetic variation in the lipoprotein(a) locus, mediated by lipoprotein(a) levels, is associated with aortic valve calcification across multiple ethnic groups and with incident clinical aortic stenosis.

Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study.

By: Fox ER, Musani SK, Barbalic M, Lin H, Yu B, Ogunyankin KO, Smith NL, Kutlar A, Glazer NL, Post WS, et al.
In the largest genome-wide association study of cardiac structure and function to date in African-Americans, researchers identified 4 genetic loci related to left ventricular mass, interventricular septal wall thickness, left ventricular internal diastolic diameter, and ejection fraction, which reached genome-wide significance.

The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish.

By: Horenstein RB, Mitchell BD, Post WS, Lütjohann D, von Bergmann K, Ryan KA, Terrin M, Shuldiner AR, Steinle NI.

Although the G574R variant is associated with moderately elevated plant sterol levels, carriers of the 574R allele had modestly lower levels of carotid wall thickness compared with noncarriers.

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic grops in the Multi-Ethnic Study of Atherosclerosis (MESA).

By: Shah SA, Herrington DM, Howard TD, Divers J, Arnett DK, Burke GL, Kao WH, Guo X, Siscovick DS, Chakravarti A, Lima JA, Psaty BM, Tomaselli GF, Rich SS, Bowden DW, Post W.

QT is a risk factor for sudden cardiac death. This study used the Multi-Ethnic Study of Atherosclerosis to examine association of QT with NOS1AP variants in an ethnically diverse cohort.

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