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M. Dominique Ashen, CRNP, PhD

Ciccarone Center Research

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M. Dominique Ashen, CRNP, PhD

M. Dominique Ashen, CRNP, PhD
Ashen, M. Dominique, CRNP, PhD

Dominique Ashen, CRNP, PhD, is the Nurse Practitioner Coordinator for the Johns Hopkins Ciccarone Center for the Prevention of Heart Disease. She also has a joint appointment in the Johns Hopkins University School of Nursing where she teaches nurse practitioner students.

Landmark Article

The role of statins in diabetes treatment.

By: Subedi BH, Tota-Maharaj R, Silverman MG, Minder CM, Martin SS, Ashen MD, Blumenthal RS, Blaha MJ.
Diabetes is considered a risk equivalent for coronary heart disease (CHD). The use of statins for primary and secondary prevention in patients with diabetes is well established and supported by robust data from randomized, controlled trials and national guidelines. It is reasonable to match the intensity of statin therapy with patients’ baseline CVD risk.

A clinician’s guide to the updated ABCs of cardiovascular disease prevention.

By: Kohli P, Whelton SP, Hsu S, Yancy CW, Stone NJ, Chrispin J, Gilotra NA, Houston B, Ashen MD, Martin SS, Joshi PH, McEvoy JW, Gluckman TJ, Michos ED, Blaha MJ, Blumenthal RS.

To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.

Usefulness of coronary and carotid imaging rather than traditional atherosclerotic risk factors to identify firefighters at increased risk for cardiovascular disease.

By: Ratchford EV, Carson KA, Jones SR, Ashen MD.
Early detection and integration of imaging with traditional risk assessment will be important in preventing premature death and disability among firefighters.

Cardiac complications of obesity.

By: Ashen MD, Blumenthal RS.

Development of a center for prevention of cardiovascular disease.

By: Ashen MD, Nell-Dybdahl CL, Sperling L, Blumenthal RS.
We discuss the key components of various types of preventive cardiology centers that can be put together in academic and private practice settings.

Vegetarian diets in cardiovascular prevention.

By: Ashen MD.

There is growing evidence that consumption of a vegetarian diet as well as specific components of a vegetarian diet lower the incidence of cardiovascular disease (CVD) and death. Vegetarian diets lower the probability of developing CVD, are effective in altering serum lipids, are beneficial in reducing blood pressure, improve glycemic control and insulin sensitivity, reduce weight, and lower mortality. Vascular effects of a vegetarian diet include a thinner carotid IMT and lower brachial artery resistance. Health care providers should be aware of the types of vegetarian diets and their risks and benefits in order to guide patients' dietary habits with the ultimate goal of reducing their CVD risk. While a patient does not have to become a complete vegetarian to reduce their CVD risk, they can make simple changes in their diet that are effective in risk reduction.

Vegetarian diets in cardiovascular prevention.

By: Ashen MD, Blumenthal RS, Sperling L.
This article reviews the strengths and limitations of the various types of vegetarian diets and variations of them.

The role of statins in diabetes mellitus.

By: Subedi BH, Tota-Maharaj R, Silverman MG, Minder CM, Martin SS, Ashen MD, Blumenthal RS, Blaha MJ.

Diabetes is considered a risk equivalent for coronary heart disease (CHD). The use of statins for primary and secondary prevention in patients with diabetes is well established and supported by robust data from randomized, controlled trials and national guidelines. The American Diabetes Association recommends that individuals with diabetes and a history of cardiovascular disease (CVD), as well as those > 40 years of age without CVD but with CVD risk factors, should be treated with a statin regardless of their baseline LDL cholesterol concentration. This review explains the rationale behind considering diabetes a CHD risk equivalent and summarizes the data for statin use in adults with diabetes without (primary prevention) and with (secondary prevention) established CVD. Although individuals with diabetes are at an increased risk for CVD and benefit from statin therapy, the risk of CVD in people with diabetes is heterogeneous. It therefore may be reasonable to match the intensity of statin therapy with patients' baseline CVD risk.

A clinician’s guide to the ABCs of cardiovascular disease prevention: The Johns Hopkins Ciccarone Center for the prevention of Heart Disease and American College of Cardiology Cardiosource approach to the Million Hearts Initiative.

By: Hsu S, Ton VK, Ashen MD, Martin SS, Gluckman TJ, Kohli P, Sisson SD, Blumenthal RS, Blaha MJ.
As part of an initiative that aims to prevent 1 million myocardial infarctions and strokes over the next 5 years, we present the simply organized “ABCDE” approach for guiding a consistent comprehensive approach to managing cardiovascular risk in daily clinical practice. We summarize recommendations related to each topic and reference landmark trials and data that support our approach.

Dyslipidemia management for secondary prevention in women with cardiovascular disease: What can we expect from non-pharmacologic strategies?

By: Whelton S, Chow GV, Ashen MD, Blumenthal RS.

In this review, we examine the effect of non-pharmacologic therapy (i.e., diet and lifestyle modification) on lipids as part of the secondary prevention strategy of cardiovascular disease in women.