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Ciccarone Center Research
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Diet & Weight
Published in: Journal of the American College of CardiologyRead on Pubmed
To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.Published in: Journal of the American Heart AssociationRead on Pubmed
Unhealthy lifestyle habits are a major contributor to coronary artery disease (CAD). The purpose of the study was to investigate the associations of smoking, weight maintenance, physical activity, and Mediterranean-style diet with coronary calcium, cardiovascular events, and mortality. We discovered that, over the course of nearly 8 years, a combination of regular exercise, healthy diet, smoking avoidance, and weight maintenance contributed to lower coronary calcium incidence, slower calcium progression, and lower all-cause mortality.Published in: American Journal of EpidemiologyRead on Pubmed
Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased systemic inflammation.
The goal of this study was to assess the independent and collective associations of hepatic steatosis, obesity, and the metabolic syndrome with elevated hsCRP levels. We evaluated 2,388 individuals without clinical cardiovascular disease between December 2004 and December 2006. Hepatic steatosis was diagnosed by ultrasound, and the metabolic syndrome was defined using National Heart, Lung, and Blood Institute criteria. We concluded that hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased odds of high hsCRP levels.Published in: Arteriosclerosis, Thrombosis & Vascular BiologyRead on Pubmed
Association between obesity, high-sensitivity C-reactive protein greater than or equal to 2 mg/L, and subclinical atherosclerosis: implications of JUPITER from the Multi-Ethnic Study of Atherosclerosis.
Levels of hsCRP are closely associated with abdominal obesity, metabolic syndrome, and atherosclerotic cardiovascular disease. The JUPITER trial has encouraged using hsCRP greater than or equal to 2 mg/L to guide statin therapy; however, the association of hsCRP and atherosclerosis, independent of obesity, remains unknown. We concluded that high hsCRP, as defined by JUPITER, was not associated with CAC and was mildly associated with carotid intima-media thickness (cIMT) in the absence of obesity. In contrast, obesity was associated with both measures of subclinical atherosclerosis independently of hsCRP status.Published in: Arteriosclerosis, Thrombosis & Vascular BiologyRead on Pubmed
A clinician’s guide to the updated ABCs of cardiovascular disease prevention.
To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.
- Journal: Journal of the American Heart Association
- Year: 2014
- Topics: Antiplatelet Therapy, ASCVD (Atherosclerotic Cardiovascular Disease), Blood Pressure, Cholesterol / Lipids / Statins, Cigarette Smoking, Diabetes & Metabolic Syndrome, Diet & Weight, Exercise and Physical Fitness, Quality of Care
- Read more articles by: Roger S. Blumenthal, MD, Michael Blaha, MD, MPH, Erin Michos, MD, MHS, Marie (Dominique) Ashen, CRNP, PhD, Seth Martin, MD, MHS, J. Bill McEvoy, MB BCh, MHS
Difference by sex but not by race/ethnicity in the visceral adipose tissue-depressive symptoms association: The Multi-Ethnic Study of Atherosclerosis.
Sex, but not race/ethnicity, was found to modify the relationship between elevated depressive symptoms and visceral fat mass. Among men, a significant positive association was found between depressive symptoms and visceral adiposity, but no significant relationship was found among women.Read on Pubmed
Understanding the high prevalence of diabetes in U.S. South Asians compared with four racial/ethnic groups: The MASALA and MESA Studies.
This study compared South Asians with four other racial/ethnic groups in the U.S. to determine whether socio-demographic, lifestyle, or metabolic factors could explain the higher diabetes prevalence and whether insulin resistance and beta-cell dysfunction occurred at younger ages and/or lower adiposity levels compared with other groups.
Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?
Among overweight women with dysglycemia, the magnitude of blood pressure reductions after intensive lifestyle change is unrelated to postmenopausal estrogen use.
Risk factors for fatty liver in the Multicenter AIDS Cohort Study.
Though treated HIV infection was associated with a lower prevalence of fatty liver, prolonged exposure to dideoxynucleoside analogs is associated with higher prevalence.Read on Pubmed
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults.
The authors sought to answer five critical questions, addressing 1) expected health benefits of weight loss; 2) cut points for body mass index (BMI) and waist circumference; 3) dietary interventions most effective for weight loss; 4) the efficacy of a comprehensive lifestyle intervention programs; and 5) bariatric surgery.
Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis.
African-Americans have a lower prevalence, and Hispanics have a higher prevalence, of fatty liver than do other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even in patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a substantial role in the phenotypic expression of fatty liver.
2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk.
The 2013 lifestyle guidelines provide guidance in three narrowly focused areas: 1) the effect of dietary patterns and macronutrient composition on CVD risk factors; 2) the effect of sodium and potassium on CVD risk factors; and 3) the effect of physical activity on blood pressure and lipids.
- Year: 2014
- Topics: ASCVD (Atherosclerotic Cardiovascular Disease), Blood Pressure, Cholesterol / Lipids / Statins, Cigarette Smoking, Diet & Weight, Exercise and Physical Fitness, Nutrition, Vitamins, Supplements, Cardiovascular Risk Assessment
- Read more articles by: Roger S. Blumenthal, MD, Seth Martin, MD, MHS
Physical environment may modify the association between depressive symptoms and change in waist circumference: the multi-ethnic study of atherosclerosis.
Elevated depressive symptoms were associated with greater increase in waist circumference among individuals living in poorly rated physical environments than in those in better-rated physical environments.