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Ciccarone Articles

Ciccarone Center Research


Journal of the American College of Cardiology

Landmark Articles

Rhinotillexis: a possible heuristic to reduce inappropriate noninvasive cardiac imaging?
By: McEvoy JW, Blaha MJ, Blumenthal RS.
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Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: Reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Heal
By: Michos ED, Sibley CT, Baer JT, Blaha MJ, Blumenthal RS.
Despite substantial risk reductions targeting low-density lipoprotein cholesterol with statins, there remains significant residual risk as evidenced by incident and recurrent CVD events among statin-treated patients. Observational studies have shown that low levels of high-density lipoprotein cholesterol (HDL-C) are associated with increased CVD risk. It remains unclear whether strategies aimed at increasing HDL-C in addition to background statin therapy will further reduce risk.
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Metabolic syndrome, diabetes, and incidence and progression of coronary calcium: the Multi-Ethnic Study of Atherosclerosis study.
By: Wong ND, Nelson JC, Granston T, Bertoni AG, Blumenthal RS, Carr JJ, Guerci A, Jacobs DR Jr, Kronmal R, Liu K, Saad M, Selvin E, Tracy R, Detrano R.
This study examines and compares the incidence and progression of CAC among persons with metabolic syndrome and diabetes mellitus (DM) versus those with neither condition. Individuals with metabolic syndrome and DM have a greater incidence and absolute progression of CAC compared with individuals without these conditions, with progression also predicting coronary heart disease events in those with metabolic syndrome and DM.
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Allopurinol acutely increases adenosine triphosphate energy delivery in failing human hearts.
By: Hirsch GA, Bottomley PA, Gerstenblith G, Weiss RG.
Intravenous administration of the XO inhibitor allopurinol acutely improves the relative and absolute concentrations of myocardial high-energy phosphates and ATP flux through creatine kinase (CK) in the failing human heart, offering direct evidence that myofibrillar CK energy delivery can be pharmaceutically augmented in the failing human heart.
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Prediction of coronary artery calcium progression in individuals with low Framingham Risk Score: the Multi-Ethnic Study of Atherosclerosis.
By: Okwuosa TM, Greenland P, Burke GL, Eng J, Cushman M, Michos ED, Ning H, Lloyd-Jones DM.
In individuals at low predicted risk, according to Framingham Risk Scores, traditional risk factors predicted CAC progression in the short term with good discrimination and calibration. Prediction improved minimally when various novel markers were added to the model.
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Coronary artery calcium scanning should be used for primary prevention: pros and cons.
By: Nasir K, Shaw LJ, Budoff MJ, Ridker PM, Peña JM.
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The association of Framingham and Reynolds risk scores with incidence and progression of coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis).
By: DeFilippis AP, Blaha MJ, Ndumele CE, Budoff MJ, Lloyd-Jones DM, McClelland RL, Lakoski SG, Cushman M, Wong ND, Blumenthal RS, Lima J, Nasir K.
Both the Framingham and Reynolds risk scores predict onset and progression of subclinical atherosclerosis. However, the Reynolds risk score may provide additional predictive information when discordance between the scoring systems exists.
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The association of the Framingham and Reynolds risk scores with incidence and progression of coronary artery calcium in MESA.
By: DeFilippis AP, Blaha MJ, Ndumele C, Budoff MJ, Lloyd-Jones D, McClelland RL, Lakoski SG, Cushman M, Wong ND, Blumenthal RS, Lima J, Nasir K.
This innovative study found that the Reynolds Risk Score was modestly better than the traditional Framingham risk score in predicting the incidence of new coronary calcification and the progression of existing calcification. This observation also applied to clinical events.
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Predictors of coronary heart disease events among asymptomatic persons with low low-density lipoprotein cholesterol MESA (Multi-Ethnic Study of Atherosclerosis).
By: Blankstein R, Budoff MJ, Shaw LJ, Goff DC Jr, Polak JF, Lima J, Blumenthal RS, Nasir K.
Our aim was to identify risk factors for CHD events among asymptomatic persons with low (?130 mg/dl) LDL-C. Among persons with low LDL-C, older age, male sex, hypertension, diabetes, and low HDL-C are associated with adverse CHD events. Even after accounting for all such variables, the presence of CAC provided incremental prognostic value. These results may serve as a basis for deciding which patients with low LDL-C may be considered for more aggressive therapies. An elevated hsCRP was not predictive of events in this population of individuals with normal LDL-C.
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Calcium score reclassification: how should baseline risk be measured?
By: McEvoy JW, Nasir K, Blumenthal RS.
A coronary artery score measurement to reclassify persons to either a low or high risk category has implications for preventive therapy strategies for patients in the broad intermediate cardiac risk category that need to be tested in a prospective, randomized manner.
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