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Advanced chronic obstructive pulmonary disease is associated with high levels of high-density lipoprotein cholesterol.

By: Reed RM, Iacono A, DeFilippis AP, Eberlein M, Girgis RE, Jones SP.
Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disease associated with numerous extrapulmonary manifestations. Amongst these is an increased risk for cardiovascular disease. The mechanisms for this association remain unclear. We sought to examine lipid trends in a well-characterized cohort of patients with severe COPD.
 
Severe COPD is associated with increased levels of HDL-C, which is partially attributable to oral steroid use. HDL-C in this population is not associated with reduced risk of angiographically proven coronary artery disease.
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