The laboratory focuses on developing novel agents to reduce neurological and myocardial injury during ischemia imposed by cardiac surgery.
Learn More About Dr. Lawton's Lab
Dr. Aziz's research efforts focus on understanding the development of ascending aortic aneurysm. Previously, Dr. Aziz had found that a gene responsible for cell guidance and migration, ROBO4, was mutated in 1-2% of patients with bicuspid aortic valve (BAV) and ascending aortic aneurysm (AsAA). Animal models with mutated ROBO4 showed mild phenotype of BAV/AsAA. To expand on this research. Dr. Aziz works with a collaborator at the Johns Hopkins Institute of Genetic Medicine to develop a technique for single cell RNA sequencing to determine why the majority of thoracic aortic aneurysms have spatial localization to either root or ascending.
Dr. Chun (Dan) W. Choi's research focuses on improvement for clinical care through extracorporeal membrane oxygenation (EMCO) treatment. There are two main objectives for Dr. Choi's research:
- Studying the impact of non-pulsatile blood flow on cerebral vascular biology. Autoregulation of vascular system is an important physiologic function that is adaptive to stress, injury, inflammation, and other major changes to the body. Autoregulation of cerebral arteries have been shown to have an important role in cardiac arrest patients and their survival. The role of cerebral autoregulation in ECPR (ECMO-CPR) for cardiac arrest patients who are refractory to conventional resuscitative efforts, with respect to neurologic outcomes and survival are currently being investigated.
- The changes in cardiovascular hemodynamic loading conditions with non-pulsatile retrograde arterial flow of peripheral ECMO is also currently being researched. Experimental studies have shown that left ventricle afterload increases with peripheral ECMO. Measuring afterload within the heart chamber requires invasive procedures. Dr. Choi is studying non- and less-invasive modalities to estimate or quantify loading conditions of the heart.
Dr. Ahmet Kilic joined the Johns Hopkins Division of Cardiac Surgery as an associate professor in 2017. Kilic’s areas of clinical research include advancing heart failure surgical treatment with a special interest in heart transplantation and mechanical circulatory support. Kilic's research is focused on improving surgical treatment for heart failure and patient outcomes.
Dr. Schena's research investigates long-term outcomes and quality of life after cardiac surgery for patients including the racial and gender disparities in cardiac surgery. He is also interested in the role of socioeconomic status in patients undergoing TAVR. Heparin-Induced Thrombocytopenia (HIT) and the response to repeated heparin exposure in cardiac surgery is also investigated. He also investigates the role of patient re-exploration for postoperative bleeding as a marker of operative quality. Dr. Schena is interested in the use of advanced technologies and artificial intelligence in cardiac surgery through the use of:
- Computed simulation and monitoring of transcathether prosthetic valves via in situ pressure sensors.
- Computed simulation assessment of aortic shear stress in patients undergoing surgical and transcatheter aottic valve replacement.
Dr. Sussman is currently investigating opiate addiction following cardiac surgery. Using retrospective data, Dr. Sussman discovered that for many cardiac surgeries that long term opiate use was associated with increased opiate use early after the procedure. It was also found that the incidence of long term opiate use was the highest in the southern United States. He is now conducting a prospective study to evaluate how well pain is controlled and the incidence of long term opiate use in patients who are given less opiate medicine early after their cardiac procedure.
Dr. Whitman's research focuses on quality outcomes and improving patient management for patients during and after their procedure, particularly in the setting of an ICU. He is currently working on identifying and eliminating intraoperative causes of acute kidney injury during cardiac surgery through the use of urinary biomarkers. Dr. Sussman is investigating the relationship between delivered O2, lactate and acute kidney injury during cardiac surgery.
Eric Etchill, M.D.
Katherine A. Giuliano, M.D.
Melissa Jones, Senior Lab Coordinator
Melissa’s administrative responsibilities include purchasing, planning, organizing and scheduling the lab’s experiments, training classes and meetings. She also helps the surgical residents write budgets, protocols and grant proposals. Her lab duties include helping set up experiments, run equipment, collect, record and maintain data. Melissa has been with the lab since 1987 and serves as its contact person.
Melissa has the task of caring for the Blalock violet.
Sean Kearney, Research Specialist
Sean came to the lab in 2017 after earning several years of research experience at the National Institutes of Health and the University of Maryland School Medicine. He provides a diverse skill set pertaining to the models performed in the Cardiac Research Lab. His daily duties include preparing and maintaining the surgical lab area and equipment, setting up and preparing the surgical instruments and supplies, and performing or assisting with the surgeries, administering anesthesia, pre- and postop care, and recovery. He helps acquire and maintain surgery records, controlled substances, and equipment inventory. Sean also participates in various facility accreditation audits such as ACUC, DEA, and Health and Safety.
Sean also has the task of caring for the Blalock violet.
Jie Wang, M.D., Research Associate
|Brian O'Rourke, Ph.D.||Cardiology|
|Mary Beth Brady, M.D.||Anesthesiology|
|Jeffrey Michael Dodd-o, M.D., Ph.D.||Anesthesiology|
|Brian Cho, M.D.||Anesthesiology|
|Mary Ann Wilson, Ph.D.||Neurology and Neuroscience|
|Lee J. Martin, Ph.D.||Pathology and Neuroscience|
|Joseph Scafidi, M.S., D.O.||Neurology|
|Mary E. Blue, Ph.D.||Neurology and Neuroscience|
|Kannan Rangaramanujam, M.S., Ph.D.||Ophthalmology and Nanomedicine|
|Lauren Leigh Jantzie, Ph.D.||Neurosurgery|
|Dody Robinson, M.D.||Neurosurgery|
View some of our past surgery residents involved in the Johns Hopkins Cardiac Surgery Research Lab.
|George J. Magovern Jr., M.D.||1982|
|Steven F. Bolling, M.D.||1983|
|Alfred S. Casale, M.D.||1983|
|Sara J. Shumway, M.D.||1984|
|Stuart R. Scott, M.D.||1984|
|Duke E. Cameron, M.D.||1985|
|Bruce R. Rosengard, M.D.||1986|
|Timothy S. Hall, M.D.||1986|
|Charles D. Fraser, M.D.||1987|
|Wen Cheng, M.D.||1987|
|Peter S. Greene, M.D.||1988|
|Peter J. Horneffer, M.D.||1988|
|Patrick Devaleria, M.D.||1989|
|R.C. Stewart Finney, M.D.||1989|
|Michael A. Acker, M.D.||1990|
|A. Marc Gillinov, M.D.||1991|
|William Curtis, M.D.||1991|
|Peter W. Cho, M.D.||1991|
|Mark J. Redmond, M.D.||1991|
|Kirk J. Fleischer, M.D.||1992|
|Malcolm V. Brock, M.D.||1992|
|Elaine Tseng, M.D.||1994|
|Jorge Salazar, M.D.||1997|
|John Doty, M.D.||1997|
|Peter Walinsky, M.D.||1999|
|Jay Shake, M.D.||2000|
|Eric Peck, M.D.||2000|
|Stephen Cattaneo, M.D.||2001|
|David Caparrelli, M.D.||2001|
|Torin Fitton, , M.D.||2002|
|Chris Barreiro, M.D.||2004|
|Jason Williams, M.D.||2005|
|Lois Nwakanma, M.D.||2006|
|Eric Weiss, M.D.||2007|
|Geoff Allen, M.D.||2008|
|George Arnaoutakis, M.D.||2009|
|Tim George, M.D.||2010|
|Claude Beaty, M.D.||2011|
|Joshua C. Grimm, M.D.||2013|
|J. Trent Magruder, M.D.||2014|
|Todd Crawford, M.D.||2015|
|Cecilia Lui, M.D.||2017|
|Xun Zhou, M.D.||2017|
|Charles Fraser, M.D.||2017|