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Ciccarone Articles

Ciccarone Center Research



Landmark Articles

The prevention of cardiovascular disease among women.
By: Michos ED.
Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly.
By: De Paula R, Aneni EC, Costa AR, Figueiredo VN, Moura FA, Freitas WM, Quaglia LA, Santos SN, Soares AA, Nadruz W, Blaha MJ, Blumenthal RS, Agatston A, Nasir K, Sposito AC.

Reduced zinc intake has been related to atherogenesis and arteriosclerosis. We verified this assumption in very old individuals, who are particularly prone to both zinc deficiency and structural and functional changes in the arterial wall. Although plasma zinc level is inversely related to systemic inflammatory activity, its plasma levels of daily intake are not associated to alterations in structure or function of the arterial wall. In the very elderly, plasma concentrations or daily intake of zinc is not related to endothelial dysfunction, arteriosclerosis, or atherosclerotic burden at coronary or carotid arteries.

The prognostic value of exercise capacity in patients with coronary artery disease: The FIT Project.
By: Hung RK, Al-Mallah MH, McEvoy JW, Whelton SP, Blumenthal RS, Nasir K, Schairer JR, Brawner C, Alam M, Keteyian SJ, Blaha MJ.
Exercise capacity was a strong predictor of morbidity and mortality in patients with coronary artery disease. Patients with similar exercise capacities had equivalent mortality risk, irrespective of baseline revascularization status.
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Mild cognitive dysfunction does not affect diabetes control in minority elders.
By: Palta P, Golden SH, Teresi JA, Palmas W, Trief P, Weinstock RS, Shea A, Manly JJ, Luchsinger JA.
Mild cognitive impairment was not associated with metabolic control of diabetes among minority elderly individuals.
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Obesity, subclinical myocardial injury and incident heart failure.
By: Ndumele CE, Coresh J, Lazo ML, Hoogeveen RC, Blumenthal RS, Folsom AR, Selvin E, Ballantyne CM, Nambi V.
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Significant depressive symptoms are not associated with diabetes control in minority elderly.
By: Palta P, Golden SH, Teresi JA, Palmas W, Trief P, Weinstock RS, Shea A, Manly JJ, Luchsinger JA.
Elevated depressive symptoms were not associated with metabolic control of diabetes among minority elderly individuals.
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Early readmission among patients with diabetes: A qualitative assessment of contributing factors.
By: Rubin DJ, Donnell-Jackson K, Jhingan R, Golden SH, Paranjape A.
Findings from this qualitative study suggest several interventions that may reduce the risk of early readmission for patients with diabetes, including inpatient diabetes education, improving communication of discharge instructions, and involving patients more in medication reconciliation and post-discharge planning.
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The wait is over: The new cholesterol treatment guidelines are here.
By: Martin SS, Blumenthal RS.

Well-intentioned CV specialists often disagree, but we wholeheartedly support at least 90% of the new guidelines, which declare that primary prevention is here to stay. While many more adults will now qualify for statin therapy, heart-healthy dietary and exercise habits remain the foundation of primary prevention efforts. Following these new guidelines will allow clinicians to markedly reduce CVD events in their patients.

Peripheral arterial disease.
By: Salameh MJ, Ratchford EV.
Stability and predictors of change in salivary cortisol measures over six years: The Multi-Ethnic Study of Atherosclerosis.
By: Wang X, Sanchez BN, Golden SH, Shrager S, Kirschbaum C, Karlmangla AS, Seeman TE, Diez Roux AV.
All features of the daily cortisol curve changed significantly over the approximately six year follow-up period—the wakeup cortisol became higher; the cortisol awakening response became smaller; both the early and late decline became flatter and the area under the curve became larger.
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