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Ciccarone Articles

Ciccarone Center Research



Landmark Articles

Effect of tube voltage (100 vs. 120 kVp) on radiation dose and image quality using prospective gating 320 row multi-detector computed tomography angiography.
By: Khan AN, Khosa F, Shuaib W, Nasir K, Blankstein R, Clouse M.

Radiation dose may be lowered from 120 to 100 kVp with preservation of image quality in patients whose BMI is greater than or equal to 27.

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Cardiac complications of obesity.
By: Ashen MD, Blumenthal RS.
Development of a center for prevention of cardiovascular disease.
By: Ashen MD, Nell-Dybdahl CL, Sperling L, Blumenthal RS.
We discuss the key components of various types of preventive cardiology centers that can be put together in academic and private practice settings.
Response to importance of pressure pulse amplification in the association of resting heart rate and arterial stiffness.
By: Whelton SP, Blaha MJ.
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How do statins work?: Changing paradigms with implications for statin allocation.
By: Blaha MJ, Martin SS.
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Influence of image acquisition on radiation dose and image quality: full versus narrow phase window acquisition using 320 MDCT.
By: Khosa F, Khan A, Nasir K, Shuaib W, Budoff M, Blankstein R, Clouse ME.
Good heart rate control and predefined narrow window acquisition result in lower radiation dose, without compromising diagnostic image quality for coronary disease evaluation.
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Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis.
By: Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, Agatston A, Blumenthal RS, Nasir K.
The presence of a high CAC burden, even among individuals without risk factors, is associated with an elevated event rate, whereas the absence of CAC, even among those with many risk factors, is associated with a low event rate. CAC scoring can further risk-stratify asymptomatic individuals at the extremes of risk factor burden.
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Derivation and validation of a novel method for more accurate estimation of LDL-C from the standard lipid profile.
By: Jones SR, Martin SS.

Low-density lipoprotein cholesterol (LDL-C) is of longstanding clinical and research interest and the primary target in national and international clinical practice guidelines. Conventionally, LDL-C is estimated by the Friedewald equation which assumes a fixed ratio of TG:VLDL-C of 5:1. Applying a factor of 5 to every individual patient is problematic given variance in the TG:VLDL-C ratio across the range of triglyceride and nonHDL-C levels. Rather than a fixed conversion factor, we have developed a method that uses a sliding scale factor to estimate VLDL-C with high precision from triglycerides and non-HDL cholesterol levels.

Effect of statin treatment on coronary plaque progression — a serial coronary CT angiography study.
By: Zeb I, Li D, Nasir K, Malpeso J, Batool A, Flores F, Dailing C, Karlsberg RP, Budoff M.

Statin therapy resulted in significantly lower progression of low attenuation plaque and noncalcified plaques compared to nonstatin users.

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Race/ethnic difference in diabetes and diabetic complications.
By: Spanakis EK, Golden SH.

This study's data provide novel updates on race/ethnic differences in children and adults with type 1 diabetes, children with type 2 diabetes, and in Latino subpopulations.

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