-
About
- Health
-
Patient Care
I Want To...
-
Research
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
-
School of Medicine
I Want to...
Ciccarone Articles
Ciccarone Center Research
-
View by Topic
- Antiplatelet Therapy
- Arrhythmias
- ASCVD (Atherosclerotic Cardiovascular Disease)
- Blood Pressure
- Cardiac CT
- Cardiovascular Risk Assessment
- Carotid Atherosclerosis
- Cerebrovascular Disease / Stroke / Cognitive Function
- Cholesterol / Lipids / Statins
- Cigarette Smoking
- Diabetes & Metabolic Syndrome
- Diet & Weight
- Disparities in Care
- Emotional Health
- Endothelial Function
- Erectile Dysfunction
- Exercise and Physical Fitness
- Family History of CVD
- Gender / Cardiovascular Disease in Women
- Genetics
- Heart Failure
- Heart Rate
- HIV
- Hormones
- Inflammation
- Markers of Thrombosis, Myocardial Injury, Wall Stress
- Mobile Health
- Nutrition, Vitamins, Supplements
- PVD – Peripheral Vascular Disease
- Quality of Care
- Renal Disease
- Rheumatoid Arthritis & Collagen Vascular Diseases
- Sleep Disorders
- Stem Cells
- Subclinical Atherosclerosis
- Uncategorized
- Vascular Imaging
- Vascular Stiffness
-
View by Journal
- American Heart Journal
- American Journal of Cardiology
- American Journal of Epidemiology
- American Journal of Hypertension
- Annals of Internal Medicine
- Arteriosclerosis, Thrombosis & Vascular Biology
- Atherosclerosis
- British Medical Journal
- Circulation
- Clinical Cardiology
- Diabetes Care
- European Heart Journal
- European Journal of Preventive Cardiology
- Heart
- Hypertension
- International Journal of Cardiology
- Journal of Hypertension
- Journal of the American College of Cardiology
- Journal of the American Heart Association
- Journal of the American Medical Association
- Mayo Clinic Proceedings
- New England Journal of Medicine
- PLoS One
-
View by Year
- Meet the Authors
Year
2011
Landmark Articles
-
This innovative study found that the Reynolds Risk Score was modestly better than the traditional Framingham risk score in predicting the incidence of new coronary calcification and the progression of existing calcification. This observation also applied to clinical events. Published in: Journal of the American College of CardiologyRead on Pubmed -
The goal of this study was to assess the independent and collective associations of hepatic steatosis, obesity, and the metabolic syndrome with elevated hsCRP levels. We evaluated 2,388 individuals without clinical cardiovascular disease between December 2004 and December 2006. Hepatic steatosis was diagnosed by ultrasound, and the metabolic syndrome was defined using National Heart, Lung, and Blood Institute criteria. We concluded that hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased odds of high hsCRP levels. Published in: Arteriosclerosis, Thrombosis & Vascular BiologyRead on Pubmed -
Read on Pubmed
The landmark Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial showed that some patients with LDL-cholesterol (LDL-C) <130 mg/dL and high-sensitivity C-reactive protein (hsCRP) concentrations of >2 mg/L benefit from treatment with rosuvastatin, although the absolute rates of cardiovascular events were low. In a population eligible for JUPITER, we established whether coronary artery calcium (CAC) might further stratify risk; additionally we compared hsCRP with CAC for risk prediction across the range of low and high hsCRP values. CAC further stratifies risk in patients eligible for JUPITER, and could be used to target subgroups of patients who are expected to derive the most, and the least, absolute benefit from statin treatment. Focusing of treatment on the subset of individuals with normal LDL-C and at least moderate subclinical atherosclerosis should allow for more appropriate allocation of resources. -
Levels of hsCRP are closely associated with abdominal obesity, metabolic syndrome, and atherosclerotic cardiovascular disease. The JUPITER trial has encouraged using hsCRP greater than or equal to 2 mg/L to guide statin therapy; however, the association of hsCRP and atherosclerosis, independent of obesity, remains unknown. We concluded that high hsCRP, as defined by JUPITER, was not associated with CAC and was mildly associated with carotid intima-media thickness (cIMT) in the absence of obesity. In contrast, obesity was associated with both measures of subclinical atherosclerosis independently of hsCRP status.
Published in: Arteriosclerosis, Thrombosis & Vascular BiologyRead on Pubmed
Evidence of dependence of lipoprotein(a) on triglyceride and HDL metabolism.
--
- Year: 2011
- Topics: Cholesterol / Lipids / Statins
- Read more articles by: Steven Jones, MD
Plaque composition and stenosis severity: is there any hope for plaque regression?
- Journal: Atherosclerosis
- Year: 2011
- Topics: ASCVD (Atherosclerotic Cardiovascular Disease), Cardiac CT
- Read more articles by: Khurram Nasir, MD, MPH
Potential use of coronary artery calcium progression to guide therapy and management of patients at risk for coronary artery disease.
This review examines the strengths and limitations of the existing data purporting to show an incremental prognostic benefit of looking at progression of CAC.
- Year: 2011
- Topics: ASCVD (Atherosclerotic Cardiovascular Disease), Cardiac CT, Cardiovascular Risk Assessment
- Read more articles by: Roger S. Blumenthal, MD, Michael Blaha, MD, MPH, Khurram Nasir, MD, MPH, J. Bill McEvoy, MB BCh, MHS, Steven Jones, MD
Short-term effect of atorvastatin on carotid artery elasticity: a pilot study.
Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.
- Year: 2011
- Topics: Cholesterol / Lipids / Statins, Vascular Stiffness
- Read more articles by: Elizabeth Ratchford, MD
Comprehensive lipid management in the coronary artery disease patient.
Low-density lipoprotein cholesterol (LDL-C) is the lipoprotein most implicated in atherosclerosis, and aggressive statin therapy remains the cornerstone of treatment. Adjunct therapies are often required to reach LDL-C goals, and recent studies have only fueled the debate over ezetimibe versus niacin. Alternate dosing regimens of high-potency statins can be used in those who cannot tolerate side effects. Residual risk may remain after LDL-C goals are achieved. Non–high-density lipoprotein cholesterol (non–HDL-C) must be calculated in patients with elevated triglycerides. Omega-3 fatty acids are most effective in lowering non–HDL-C. Low HDL-C levels can be raised with niacin, but clinical events may not be significantly reduced. Newer therapeutic targets, such as cholesteryl ester transfer protein (CETP) inhibitors, raise HDL-C and are being evaluated for safety and efficacy. Several ongoing, randomized controlled trials are investigating the relative efficacy of adjunctive therapies for reducing coronary heart disease events in high-risk patients.
- Year: 2011
- Topics: Cholesterol / Lipids / Statins
- Read more articles by: Roger S. Blumenthal, MD, Michael Blaha, MD, MPH, Marie (Dominique) Ashen, CRNP, PhD
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI. SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there are suggestive associations with both CAC and MI of SNPs in additional loci. Multiple genetic loci are associated with development of both underlying coronary atherosclerosis and clinical events.
- Journal: Circulation
- Year: 2011
- Topics: ASCVD (Atherosclerotic Cardiovascular Disease), Cardiac CT, Genetics
- Read more articles by: Wendy S. Post, MD, MS
Association between sleep apnea, snoring, incident cardiovascular events and all-cause mortality in an adult population: MESA.
We assessed the association between sleep apnea, snoring, incident CV events and all-cause mortality in the Multi Ethnic Study of Atherosclerosis (MESA) cohort and concluded that sleep apnea, but not habitual snoring, was associated with high incident CV events and all-cause mortality in a multi-ethnic population-based study of adults free of clinical CV disease at baseline.
- Journal: Atherosclerosis
- Year: 2011
- Topics: Sleep Disorders, Cardiovascular Risk Assessment
- Read more articles by: Roger S. Blumenthal, MD
Differentiation of severe coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis.
Both high and very high levels of coronary artery calcium are associated with an elevated risk of CHD events in those without symptomatic CHD at baseline; however, very high CAC is associated with an increased risk of angina, but not CHD death or MI, as compared to high CAC.
- Journal: Atherosclerosis
- Year: 2011
- Topics: Cardiac CT, Cardiovascular Risk Assessment
- Read more articles by: Roger S. Blumenthal, MD, Wendy S. Post, MD, MS
Impact of lung transplantation on serum lipids in COPD.
Severe chronic obstructive pulmonary disease is associated with high HDL cholesterol (HDL-C). We sought to examine the effect of lung transplantation on lipid profiles in patients with COPD. In patients with COPD, lung transplantation results in reductions in the serum levels of HDL-C. These changes are not observed in patients undergoing lung transplantation for diagnoses other than COPD.
- Year: 2011
- Topics: Cholesterol / Lipids / Statins
- Read more articles by: Steven Jones, MD
Short-term effect of atorvastatin on carotid artery elasticity.
Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.
- Year: 2011
- Topics: Carotid Atherosclerosis, Cholesterol / Lipids / Statins, Vascular Stiffness
- Read more articles by: Elizabeth Ratchford, MD