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Ciccarone Center Research

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Hormones

Stability and predictors of change in salivary cortisol measures over six years: The Multi-Ethnic Study of Atherosclerosis.
By: Wang X, Sanchez BN, Golden SH, Shrager S, Kirschbaum C, Karlmangla AS, Seeman TE, Diez Roux AV.
All features of the daily cortisol curve changed significantly over the approximately six year follow-up period—the wakeup cortisol became higher; the cortisol awakening response became smaller; both the early and late decline became flatter and the area under the curve became larger.
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Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men.
By: Ketlogetswe KS, Post WS, Li X, Palella FJ Jr, Jacobson LP, Margolick JB, Kingsley LA, Witt MD, Dobs AS, Budoff MJ, Brown TT.
Adiponectin levels were lower in HIV-infected men and related to the severity of subclinical atherosclerosis, independent of traditional CVD risk factors.
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Relationship between the cortisol awakening response and other features of the diurnal cortisol rhythm: the Multi-Ethnic Study of Atherosclerosis.
By: Golden SH, Sánchez BN, Wu M, Champaneri S, Diez Roux AV, Seeman T, Wand GS.
Bedtime cortisol showed the strongest correlation with total cortisol area under the curve, suggesting it may be a marker of daily cortisol exposure.
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25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis.
By: Blondon M, Sachs M, Hoofnagle AN, Ix JH, Michos ED, Korcarz C, Gepner AD, Siscovick DS, Kaufman JD, Stein JH, Kestenbaum B, de Boer IH.
The consistent lack of association of vitamin D and parathyroid hormone with carotid intima-media thickness and plaque suggests that these hormones may influence cardiovascular risk through pathways not reflected by carotid atherosclerosis.
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Relationship between the cortisol awakening response and other features of the diurnal cortisol rhythm: The Multi-Ethnic Study of Atherosclerosis.
By: Golden SH, Sanchez BN, Wu M, Champaneri S, Diez Roux AV, Seeman T, Wand GS.
Researchers for this study conclude that bedtime cortisol showed the strongest correlation with total cortisol area under the curve, suggesting it may be a marker of daily cortisol exposure.
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Sex steroid levels and response to weight loss interventions among postmenopausal women in the Diabetes Prevention Program.
By: Kim C, Barrett-Connor E, Randolph JF, Kong S, Nan B, Mather K, Golden SH and the Diabetes Prevention Program Research Group.

This study found that, among nonestrogen users, baseline sex steroids were not associated with reductions in weight or waistline circumference.

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The association of elective hormone therapy with changes in lipids among glucose intolerant postmenopausal women in the diabetes prevention program.
By: Golden SH, Kim C, Barrett-Connor E, Nan B, Kong S, Goldberg R; the Diabetes Prevention Program Research Group.

It is unclear how lipids change in response to lifestyle modification or metformin among postmenopausal glucose intolerant women using and not using hormone therapy (HT). We examined the one-year changes in lipids among postmenopausal, prediabetic women in the Diabetes Prevention Program (DPP), and whether changes were mediated by sex hormones. The beneficial effects of ILS and metformin on lowering LDL-C and raising HDL-C differ depending upon concurrent HT use.

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Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey.
By: Zhang Y, Post WS, Cheng A, Blasco-Colmenares E, Tomaselli GF, Guallar E.
Variation in thyroid hormone levels in the general population, even within the normal range, was associated with various changes in electrocardiograms.
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Diurnal salivary cortisol is associated with body mass index and waist circumference: the multiethnic study of atherosclerosis.
By: Champaneri S, Xu X, Carnethon MR, Bertoni AG, Seeman T, DeSantis AS, Diez Roux A, Shrager S, Golden SH.
Researchers showed that higher body mass index and waistline circumference are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates.
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Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.
By: Kim C, Golden SH, Mather KJ, Laughlin GA, Kong S, Nan B, Barrett-Connor E, Randolph JF Jr; Diabetes Prevention Program Research Group.

This study found that, among postmenopausal women, there were significant race/ethnicity differences in baseline sex hormones and changes in sex hormones.

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