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Ciccarone Articles

Ciccarone Center Research


Heart Failure

Landmark Articles

Obesity, subclinical myocardial injury and incident heart failure.
By: Ndumele CE, Coresh J, Lazo ML, Hoogeveen RC, Blumenthal RS, Folsom AR, Selvin E, Ballantyne CM, Nambi V.
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Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study.
By: Lutsey PL, Alonso A, Michos ED, Loehr LR, Astor BC, Coresh J, Folsom AR.
Low serum magnesium and high serum phosphorus and calcium were independently associated with greater risk of incident HF in this population-based cohort.
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Metabolomic analysis of pressure-overloaded and infarcted mouse hearts.
By: Sansbury BE, De Martino AM, Xie Z, Brooks AC, Brainard RE, Watson LJ, DeFilippis AP, Cummins TD, Harbeson MA, Brittian KR, Prabhu SD, Bhatnagar A, Jones SP, Hill BG.
These findings reveal extensive metabolic remodeling common to both hypertrophic and failing hearts that are indicative of extracellular matrix remodeling, insulin resistance and perturbations in amino acid, and lipid and nucleotide metabolism.
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Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the atherosclerosis risk in communities study.
By: Lutsey PL, Alonso A, Selvin E, Pankow JS, Michos ED, Agarwal SK, Loehr LR, Eckfeldt JH, Coresh J.
High levels of serum FGF-23 were associated with increased risk of coronary heart disease, heart failure, and cardiovascular mortality in this large, biracial, population-based cohort.
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Two classic hemodynamic findings for hypertrophic cardiomyopathy.
By: Barth AS, Abraham T, Ndumele C, Zakaria S.
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Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem...
By: Karantalis V, DiFede DL, Gerstenblith G, et al.

Intramyocardial injection of autologous mesenchymal stem cells into akinetic yet nonrevascularized segments produces comprehensive regional functional restitution, which in turn drives improvement in global LV function.

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Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally? An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial.
By: Suncion VY, Ghersin E, Fishman JE, Zambrano JP, Karantalis V, Mandel N, Nelson KH, Gerstenblith G, DiFede Velazquez DL, et al.

Scar-size reduction and ventricular functional responses preferentially occurred at the sites of transendocardial stem cell injection, compared to nontransendocardial stem cell injection sites.

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Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis).
By: Opdahl A, Ambale Venkatesh B, Fernandes VR, Wu CO, Nasir K, Choi EY, Almeida AL, Rosen B, Carvalho B, Edvardsen T, Bluemke DA, Lima JA.
Elevated resting heart rate was associated with increased risk for incident HF in asymptomatic participants in the MESA trial; higher heart rate was related to development of regional and global LV dysfunction independent of subclinical atherosclerosis and coronary heart disease.
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Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).
By: Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E.
Intracoronary administration of autologous cardiosphere-derived cells did not raise significant safety concerns.
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Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death.
By: Bottomley PA, Panjrath GS, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G, Weiss RG.
Reduced CK flux may be a potential heart failure (HF) treatment target.
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