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Ciccarone Articles

Ciccarone Center Research


Diet & Weight

Landmark Articles

Obesity, subclinical myocardial injury and incident heart failure.
By: Ndumele CE, Coresh J, Lazo ML, Hoogeveen RC, Blumenthal RS, Folsom AR, Selvin E, Ballantyne CM, Nambi V.
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A clinician’s guide to the updated ABCs of cardiovascular disease prevention.
By: Kohli P, Whelton SP, Hsu S, Yancy CW, Stone NJ, Chrispin J, Gilotra NA, Houston B, Ashen MD, Martin SS, Joshi PH, McEvoy JW, Gluckman TJ, Michos ED, Blaha MJ, Blumenthal RS.

To facilitate the guideline-based implementation of treatment recommendations in the ambulatory setting and to encourage participation in the multiple preventive health efforts that exist, we have organized several recent guideline updates into a simple ABCDEF approach. We would remind clinicians that evidence-based medicine is meant to inform recommendations but that synthesis of patient-specific data and use of appropriate clinical judgment in each individual situation is ultimately preferred.

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Difference by sex but not by race/ethnicity in the visceral adipose tissue-depressive symptoms association: The Multi-Ethnic Study of Atherosclerosis.
By: Remigio-Baker RA, Allison MA, Schreiner P, Szklo M, Crum RM, Leoutsakos J, Franco M, Carnethon MR, Nettleton J, Mujahid M, Diez Roux AV, Jensky N, Golden SH.
Sex, but not race/ethnicity, was found to modify the relationship between elevated depressive symptoms and visceral fat mass. Among men, a significant positive association was found between depressive symptoms and visceral adiposity, but no significant relationship was found among women.
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Understanding the high prevalence of diabetes in U.S. South Asians compared with four racial/ethnic groups: The MASALA and MESA Studies.
By: Kanaya AM, Herrington D, Vittinghoff E, Ewing SK, Liu K, Blaha MJ, Dave SS, Qureshi F, Kandula NR.
This study compared South Asians with four other racial/ethnic groups in the U.S. to determine whether socio-demographic, lifestyle, or metabolic factors could explain the higher diabetes prevalence and whether insulin resistance and beta-cell dysfunction occurred at younger ages and/or lower adiposity levels compared with other groups.
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Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?
By: Kim C, Golden SH, Kong S, Nan B, Mather KJ, Barrett-Connor, Diabetes Prevention Program Research Group.

Among overweight women with dysglycemia, the magnitude of blood pressure reductions after intensive lifestyle change is unrelated to postmenopausal estrogen use.

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Risk factors for fatty liver in the Multicenter AIDS Cohort Study.
By: Price JC, Seaberg EC, Latanich R, Budoff MJ, Kingsley LA, Palella FJ Jr, Witt MD, Post WS, Thio CL.
Though treated HIV infection was associated with a lower prevalence of fatty liver, prolonged exposure to dideoxynucleoside analogs is associated with higher prevalence.
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2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults.
By: Abd TT, Misra S, Ojeifo O, Martin SS, Blumenthal RS, Foody J, Wong ND.
The authors sought to answer five critical questions, addressing 1) expected health benefits of weight loss; 2) cut points for body mass index (BMI) and waist circumference; 3) dietary interventions most effective for weight loss; 4) the efficacy of a comprehensive lifestyle intervention programs; and 5) bariatric surgery.
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Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis.
By: Tota-Maharaj R, Blaha MJ, Zeb I, Katz R, Blankstein R, Blumenthal RS, Budoff MJ, Nasir K.
African-Americans have a lower prevalence, and Hispanics have a higher prevalence, of fatty liver than do other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even in patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a substantial role in the phenotypic expression of fatty liver.
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2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk.
By: Abd TT, Misra S, Ojeifo O, Martin SS, Blumenthal RS, Foody J, Wong ND.
The 2013 lifestyle guidelines provide guidance in three narrowly focused areas: 1) the effect of dietary patterns and macronutrient composition on CVD risk factors; 2) the effect of sodium and potassium on CVD risk factors; and 3) the effect of physical activity on blood pressure and lipids.
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Physical environment may modify the association between depressive symptoms and change in waist circumference: the multi-ethnic study of atherosclerosis.
By: Remigio-Baker RA, Diez Roux AV, Szklo M, Crum RM, Leoutsakos JM, Franco M, Schreiner PJ, Carnethon MR, Nettleton JA, Mujahid MS, Michos ED, Gary-Webb TL, Golden SH.

Elevated depressive symptoms were associated with greater increase in waist circumference among individuals living in poorly rated physical environments than in those in better-rated physical environments.

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