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Ciccarone Articles

Ciccarone Center Research


Cardiac CT

Landmark Articles

Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the Multi-Ethnic Study of Atherosclerosis: A secondary analysis of a prospective, population-based cohort.
By: Tota-Maharaj R, Blaha MJ, Blankstein R, Silverman M, Eng J, Shaw LJ, Blumenthal RS, Budoff MJ, Nasir K.
The potent predictive value of coronary artery calcium burden applies to middle-aged as well as older adults.
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Association between lipoprotein associated phospholipase A2 mass and subclinical coronary and carotid atherosclerosis in retired national football league players.
By: Pokharel Y, Nambi V, Martin SS, Hoogeveen RC, Nasir K, Khera A, Wong ND, Jones PH, Boone J, Roberts AJ, Ballantyne CM, Virani SS.

Retired National Football League (NFL) players were reported to have high prevalence of cardiovascular risk factors. Lipoprotein Associated Phospholipase A2 (LpPLA2) has shown to be associated with cardiovascular disease in the general population, but it is unknown whether such an association exists in retired NFL players. Our objective was to assess whether LpPLA2 mass was associated with coronary artery calcium (CAC) and carotid artery plaque (CAP) in retired NFL players. LpPLA2 mass was not associated with coronary or carotid subclinical atherosclerosis in retired NFL players.

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Role of non-contrast coronary CT for detection of coronary heart disease and cardiovascular disease risk stratification.
By: Waheed S, Nasir K.
Coronary artery calcium score.
By: Polonsky TS, Blumenthal RS, Greenland P.
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Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter AIDS Cohort Study.
By: Miller PE, Budoff M, Zikusoka M, Li X, Palella F Jr, Kingsley LA, Witt MD, Sharrett AR, Jacobson LP, Post WS.
The lower prevalence of CAC in black men compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
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New insights into diagnostic testing guidelines in women.
By: Metkus Jr. TS, Blumenthal RS, Joshi PH.

An update to the 2005 Guidelines on the Role of Noninvastive Testing in the Clinical Evaluation of Women with Suspected Ischemic Heart Disease was authored in response to the documented gap in appropriate diagnosis and treatment of ischemic heart disease between women and men.

Coronary artery calcium testing: exploring the need for a randomized trial.
By: McEvoy JW, Blaha MJ.
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Coronary artery disease detected by coronary CT angiography is associated with intensification of preventive medical therapy and lower LDL cholesterol.
By: Hulten E, Bittencourt MS, Singh A, O’Leary D, Christman MP, Osmani W, Abbara S, Steigner M, Truong QA, Nasir K, Rybicki F, Klein J, Hainer J, Brady TJ, Hoffmann U, Ghoshhajra B, Hachamovitch R, Di Carli MF, Blankstein R.
Coronary computed tomography angiography (CCTA) may lead to increased use of prognostically beneficial therapies in patients identified as having extensive, non-obstructive CAD.
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Neck circumference is not associated with subclinical atherosclerosis in retired national football league players.
By: Pokharel Y, Macedo FY, Nambi V, Martin SS, Nasir K, Wong ND, Boone J, Roberts AJ, Ballantyne CM, Virani SS.
In retired NFL players with a high prevalence of CAC and carotid artery plaque, neck circumference was not associated with coronary or carotid subclinical atherosclerosis.
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Coronary computed tomography as a cost-effective test strategy for coronary artery disease assessment — a systematic review.
By: Zeb I, Abbas N, Nasir K, Budoff MJ.
CCTA may represent a cost-effective strategy and may be associated with less downstream testing for diagnosis of stable chest pain patients in low- to intermediate-risk patients; for low-risk acute chest pain patients; however, use of CCTA is associated with expedited patient management, less cost and safe exclusion of acute coronary syndrome.
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