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Ciccarone Articles

Ciccarone Center Research


Cardiac CT

Landmark Articles

Reproducibility of measurements by multi-detector computed tomography: Intra- and inter-reader measures for epicardial and intra-thoracic adipose tissue.
By: Rezaeian P, Razipour A, Li D, Zeb I, Baskett M, Post WS, Budoff MJ.
Beyond BMI: the "metabolically healthy obese" phenotype and its association with clinical/subclinical cardiovascular disease and all-cause mortality: a systematic review.
By: Roberson LL, Aneni EC, Maziak W, Agatston A, Feldman T, Rouseff M, Tran T, Blaha MJ, Santos RD, Sposito A, Al-Mallah MH, Blankstein R, Budoff MJ, Nasir K.

This review analyzed the literature that has examined the burden of CVD and all-cause mortality in the metabolically healthy obese population.

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Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis.
By: Martin SS, Blaha MJ, Blankstein R, Agatston A, Rivera JJ, Virani SS, Ouyang P, Jones SR, Blumenthal RS, Budoff MJ, Nasir K.
CAC scoring can help match statin therapy to absolute atherosclerotic CVD risk.
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Subclinical cardiovascular disease in plaque psoriasis: association or causal link?
By: Shaharyar S, Warraich H, McEvoy JW, Oni E, Ali SS, Karim A, Jamal O, Blaha MJ, Blumenthal RS, Fialkow J, Cury R, Budoff MJ, Agatston AA, Nasir K.

Since patients with psoriasis have an increased burden of subclinical atherosclerosis and endothelial dysfunction, those with greater severity and/or disease duration should be targeted for primary screening for cardiovascular disease risk reduction.

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Effect of tube voltage (100 vs. 120 kVp) on radiation dose and image quality using prospective gating 320 row multi-detector computed tomography angiography.
By: Khan AN, Khosa F, Shuaib W, Nasir K, Blankstein R, Clouse M.

Radiation dose may be lowered from 120 to 100 kVp with preservation of image quality in patients whose BMI is greater than or equal to 27.

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Influence of image acquisition on radiation dose and image quality: full versus narrow phase window acquisition using 320 MDCT.
By: Khosa F, Khan A, Nasir K, Shuaib W, Budoff M, Blankstein R, Clouse ME.
Good heart rate control and predefined narrow window acquisition result in lower radiation dose, without compromising diagnostic image quality for coronary disease evaluation.
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Impact of coronary artery calcium on coronary heart disease events in individuals at the extremes of traditional risk factor burden: the Multi-Ethnic Study of Atherosclerosis.
By: Silverman MG, Blaha MJ, Krumholz HM, Budoff MJ, Blankstein R, Sibley CT, Agatston A, Blumenthal RS, Nasir K.
The presence of a high CAC burden, even among individuals without risk factors, is associated with an elevated event rate, whereas the absence of CAC, even among those with many risk factors, is associated with a low event rate. CAC scoring can further risk-stratify asymptomatic individuals at the extremes of risk factor burden.
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Effect of statin treatment on coronary plaque progression — a serial coronary CT angiography study.
By: Zeb I, Li D, Nasir K, Malpeso J, Batool A, Flores F, Dailing C, Karlsberg RP, Budoff M.

Statin therapy resulted in significantly lower progression of low attenuation plaque and noncalcified plaques compared to nonstatin users.

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Vitamin D deficiency is associated with development of subclinical coronary artery disease in HIV-infected African American cocaine users with low Framingham-defined cardiovascular risk.
By: Lai H, Fishman EK, Gerstenblith G, Moore R, Brinker JA, Keruly JC, Chen S, Detrick B, Lai S.

The incidence of subclinical CAD in HIV-infected African-American cocaine users with low CAD risk is high, especially in those with vitamin D deficiency.

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Absolute coronary artery calcium score is the best predictor of non-calcified plaque involvement in patients with low calcium scores (1–100).
By: Tam LM, Joonseok K, Blumenthal RS, Nasir K, Al-Mallah MH, Blaha MJ.
This study looked at the predictors on non-calcified plaque in persons with mild coronary calcification.
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