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Ciccarone Center Research

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Quality of Care

Landmark Articles

Implementing and evaluating a multicomponent inpatient diabetes management program: putting research into practice.
By: Munoz M, Pronovost P, Dintzis J, Kemmerer T, Wang NY, Chang YT, Efird L, Berenholtz SM, Golden SH.
Inpatient glucose management remains an important area for patient safety, quality improvement, and clinical research, and the implementation model should guide other hospitals in their glucose management initiatives.
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Evidence-based use of statins for primary prevention of cardiovascular disease.
By: Minder CM, Blaha MJ, Horne A, Michos ED, Kaul S, Blumenthal RS.
Current national guidelines recommend statins as part of a comprehensive primary prevention strategy for patients with elevated low-density lipoprotein cholesterol at increased risk for developing coronary heart disease within 10 years. However, we believe data provide compelling evidence to support the use of statins for primary prevention in patients with risk factors for developing coronary heart disease over the next decade.
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Neighborhood health-promoting resources and obesity risk (the Multi-Ethnic Study of Atherosclerosis).
By: Auchincloss AH, Mujahid MS, Shen M, Michos ED, Whitt-Glover MC, Diez Roux AV.

Altering the residential environment so that healthier behaviors and lifestyles can be easily chosen may be a precondition for sustaining existing healthy behaviors and for adopting new healthy behaviors.

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Comparison of the Diamond-Forrester method and Duke Clinical Score to predict obstructive coronary artery disease by computed tomographic angiography.
By: Wasfy MM, Brady TJ, Abbara S, Nasir K, Ghoshhajra BB, Truong QA, Hoffmann U, Di Carli MF, Blankstein R.

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Achieving secondary prevention low-density lipoprotein particle concentration goals using lipoprotein cholesterol-based data.
By: Mathews SC, Mallidi J, Kulkarni K, Toth PP, Jones SR.

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Comparison of exercise treadmill testing with cardiac computed tomography angiography among patients presenting to the emergency room with chest pain: the Rule Out Myocardial Infarction Using Computer-Assisted Tomography (ROMICAT) study.
By: Blankstein R, Ahmed W, Bamberg F, Rogers IS, Schlett CL, Nasir K, Fontes J, Tawakol A, Brady TJ, Nagurney JT, Hoffmann U, Truong QA.
Although patients with a high number of clinical risk factors are more likely to have obstructive coronary artery disease, those who are young or who would be expected to have a very high exercise capacity are unlikely to have coronary stenosis and therefore may benefit from initial treadmill testing instead of CTA.
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Cardiovascular aging: the next frontier in cardiovascular prevention.
By: Najaar SS, Lakatta EG, Gerstenblith G.
Age is the dominant risk for CVD, but it has traditionally been viewed as a nonmodifiable risk factor. This chapter examines physiologic aging and clinical interventions to slow this process. Future studies should examine whether such interventions can slow the process of accelerated cardiovascular aging and attenuate the impact of age as the dominant risk factor for CVD.
Cost-effective prevention of coronary heart disease.
By: Ashen MD.

Healthcare designed to prevent future illness and minimize progression of current illness is a powerful means to improve quality of life, minimize mortality, and decrease health care costs. Coronary heart disease (CHD) is the #1 killer of both men and women in the United States. Prevention of CHD involves early identification and management of risk factors through assessment and treatment. The goal in CHD prevention is to produce the largest relative risk reduction, the smallest number needed to treat, and the lowest cost per quality-adjusted life year saved. Evidence-based treatment strategies have been shown to cost-effectively minimize CHD risk and reduce morbidity and mortality. Approaches that encompass the lifespan, solidify assessment and treatment strategies in the primary care setting, and reach into the workplace, schools, churches, and homes to make small changes in risk factors across an entire population are important areas for improving CHD preventive care. Public health policies are also necessary to support implementation of preventive programs.