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Cardiac CT

Landmark Articles

Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men.
By: Ketlogetswe KS, Post WS, Li X, Palella FJ Jr, Jacobson LP, Margolick JB, Kingsley LA, Witt MD, Dobs AS, Budoff MJ, Brown TT.
Adiponectin levels were lower in HIV-infected men and related to the severity of subclinical atherosclerosis, independent of traditional CVD risk factors.
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Determinants of intrathoracic adipose tissue volume and associations with cardiovascular disease risk factors in Amish.
By: Liu X, Post WS, McLenithan J, Terrin M, Magder L, Zeb I, Budoff M, Mitchell BD.
These data do not provide support for a significant role for intrathoracic fat in the development of CAC.
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Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease?: Clinical risk scores are not sufficient to define primary prevention treatment strategies among asymptomatic patients.
By: Blaha MJ, Silverman MG, Budoff MJ.
Subclinical atherosclerosis testing with CAC is currently superior to any combination of risk factors and serum biomarkers.
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Risk factors: new risk-assessment guidelines— more or less personalized?
By: Blaha MJ, Blumenthal RS.
The new ACC/AHA cardiovascular-risk guidelines feature updated equations for women, distinct equations for African-Americans, and include stroke prediction. However, the equations rely on the same traditional risk factors as previous versions, are driven predominantly by age, and curtail the intermediate-risk group, in which personalized risk assessment is recommended.
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Critical review of high-sensitivity C-reactive protein and coronary artery calcium for the guidance of statin allocation: head-to-head comparison of the JUPITER and St. Francis Heart Trials.
By: Kim J, McEvoy JW, Nasir K, Budoff MJ, Arad Y, Blumenthal RS, Blaha MJ.
This analysis looks at the strengths and limitations of two large trials of statin therapy based on persons with an elevated hsCRP, CAC score, or both.
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Prognostic value of nonobstructive and obstructive coronary artery disease detected by coronary computed tomography angiography to identify cardiovascular events.
By: Bittencourt MS, Hulten E, Ghoshhajra B, D, Christman MP, Montana P, Truong QA, Steigner M, Murthy VL, Rybicki FJ, Nasir K, Gowdak LH, Hainer J, Brady TJ, Di Carli MF, Hoffmann U, Abbara S, Blankstein R.
Regardless of whether obstructive or nonobstructive disease is present, the extent of plaque detected by CCTA enhances risk assessment.
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Incremental prognostic value of coronary artery calcium score versus CT angiography among symptomatic patients without known coronary artery disease.
By: Hulten E, Bittencourt MS, Ghoshhajra B, O’Leary D, Christman MP, Blaha MJ, Truong Q, Nelson K, Montana P, Steigner M, Rybicki F, Hainer J, Brady TJ, Hoffmann U, Di Carli MF, Nasir K, Abbara S, Blankstein R.
Among symptomatic patients with a CAC score of zero, a very low (1-2%) prevalence of potentially obstructive CAD can occur, although this finding was not associated with future coronary revascularization or adverse prognosis within two years.
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Modifiable lifestyle risks, cardiovascular disease, and all-cause mortality.
By: Ahmed HM, Blaha MJ, Blumenthal RS.
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Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA).
By: Pandey AK, Blaha MJ, Sharma K, Rivera J, Budoff MJ, Blankstein R, Al-Mallah M, Wong ND, Shaw L, Carr J, O’Leary D, Lima JA, Szklo M, Blumenthal RS, Nasir K.

A multiethnic, population-based study showed that a family history of premature CHD is associated with enhanced development and progression of subclinical disease, independent of other risk factors.

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All-cause mortality in asymptomatic persons with extensive Agatston scores above 1000.
By: Patel J, Blaha MJ, McEvoy JW, Qadir S, Tota-Maharaj R, Shaw LJ, Rumberger JA, Callister TQ, Berman DS, Min JK, Raggi P, Agatston AA, Blumenthal RS, Budoff MJ, Nasir K.
Increasing calcified plaque in coronary arteries continues to predict a graded decrease in survival among patients with extensive Agatston score > 1000 with no apparent upper threshold.
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