The relationship of cigarette smoking with inflammation and subclinical vascular disease: The Multi-Ethnic Study of Atherosclerosis.
By: McEvoy J, Nasir K, DeFilippis A, Lima J, Bluemke D, Hundley WG, Barr RG, Budoff M, Szklo M, Navas-Acien A, Polak J, Blumenthal R, Post W, Blaha M.
We sought to assess the impact of smoking status, cumulative pack-years, and time since cessation (the latter in former smokers only) on 3 important domains of cardiovascular disease: inflammation, vascular dynamics and function, and subclinical atherosclerosis. These findings expand our understanding of the harmful effects of smoking and help explain the cardiovascular benefits of smoking cessation.
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Arteriosclerosis, Thrombosis & Vascular Biology
- Year: 2015
- Read more articles by:
Roger S. Blumenthal, MD,
Michael Blaha, MD, MPH,
Khurram Nasir, MD, MPH,
Wendy S. Post, MD, MS,
J. Bill McEvoy, MB BCh, MHS
Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter AIDS Cohort Study.
By: Miller PE, Budoff M, Zikusoka M, Li X, Palella F Jr, Kingsley LA, Witt MD, Sharrett AR, Jacobson LP, Post WS.
The lower prevalence of CAC in black men compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
Troponin elevations only detected with a high-sensitivity assay: Clinical correlations and prognostic significance.
By: Korley FK, Schulman SP, Sokoll LJ, DeFilippis AP, Stolbach AI, Bayram JD, Saheed MO, Omron R, Fernandez C, Lwin A, Cai SS, Post WS, Jaffe AS.
With clinical use of high-sensitivity troponin I (hsTnI), more frequent troponin elevations will occur. However, the burden and implications of these elevations are not well understood. The authors quantified the prevalence of elevated hsTnI in patients presenting with possible acute coronary syndrome (ACS) who do not have elevated troponin with a current generation assay (cardiac troponin I [cTnI]) and determined the association of these newly detected elevations with a composite of all-cause mortality and subsequent cardiac hospitalization. On the initial sample, 9% to 11% of subjects without cTnI elevation had hsTnI elevation. Although the majority of the patients with these newly detected hsTnI elevations did not have ACS, they had a higher risk for all-cause mortality and subsequent cardiac hospitalization.
Vitamin D and subclinical cerebrovascular disease: The Atherosclerosis Risk in Communities Brain Magnetic Resonance Imaging Study.
By: Michos ED, Carson KA, Schneider AL, Lutsey PL, Xing L, Sharrett AR, Alonso A, Coker LH, Gross M, Post W, Mosley TH, Gottesman RF.
single measure of 25-hydroxy vitamin D was not cross-sectionally associated with white matter hyper-intensities grade or prevalent subclinical infarcts and was not prospectively associated with their progression or subclinical brain infarcts seen on serial cerebral MRIs obtained approximately 10 years apart.
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
By: Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, et al.
This integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, long-QT syndrome, and sudden cardiac death.
Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb.
By: Polak JF, Post WS, Carr JJ, Szklo M, O’Leary DH.
Common carotid artery intima-media thickness (IMT) measurements made below the carotid bulb are smaller but have more consistent associations with CHD risk factors and outcomes compared with IMT measured near the bulb.
Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.
By: Schneider AL, Lutsey PL, Alonso A, Gottesman RF, Sharrett AR, Carson KA, Gross M, Post WS, Knopman DS, Mosley TH, Michos ED.
This study of late middle age white and black participants did not find significant associations between lower levels of 25-hydroxy vitamin D with lower cognitive test scores at baseline, change in scores over time or dementia risk.
Risk factors for fatty liver in the Multicenter AIDS Cohort Study.
By: Price JC, Seaberg EC, Latanich R, Budoff MJ, Kingsley LA, Palella FJ Jr, Witt MD, Post WS, Thio CL.
Though treated HIV infection was associated with a lower prevalence of fatty liver, prolonged exposure to dideoxynucleoside analogs is associated with higher prevalence.
Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis.
By: Brener M, Ketlogetswe K, Budoff M, Jacobson LP, Li X, Rezaeian P, Razipour A, Palella FJ Jr, Kingsley L, Witt MD, George RT, Post WS.
Greater epicardial fat volume in HIV-infected men and its association with coronary plaque and antiretroviral therapy duration suggest potential mechanisms that might lead to increased risk for cardiovascular disease in HIV.
Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness.
By: Polak JF, Sacco RL, Post WS, Vaidya D, Arnan MK, O’Leary DH.
Though common carotid IMT is not associated with stroke, inter-adventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT.