The liver cells (magenta) of untreated obese mice (left) contain many large, white droplets of fat while those of obese mice treated with valproic acid (right) have much less fat accumulation. Used with permission. Lindsay B. Avery and Namandjé N. Bumpus. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol January 2014; 85:1-10.