The Greenberg Bladder Cancer Institute granted two awards in 2017.

Nuclear receptor-activated transcriptomic signatures in human urothelium for the deconvolution of tumour transcriptomes.

Simon Baker & Jenny Southgate, Jack Birch Unit, University of York, UK.

Although nuclear receptors (NRs) play a key role in regulating urothelial differentiation and the molecular landscape of bladder cancer, the contribution of individual NRs to downstream transcriptional networks is poorly resolved. Here we propose to generate comprehensive transcriptional subnetworks from normal human urothelial cells as a framework from which to identify and target specific cancer-related programs.     

Understanding Sexual Dysfunction in Women with Bladder Cancer Undergoing Radical Cystectomy

Natasha Gupta, Johns Hopkins University School of Medicine, Baltimore, MD

Sexual dysfunction is a significant quality of life issue among women undergoing radical cystectomy for bladder cancer. The purpose of this study is to gain an understanding of the components of sexual health and dysfunction among women undergoing radical cystectomy and to assess variations in national practice patterns among urologists regarding operative techniques that can impact sexual function in women.