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Greenberg Bladder Cancer Institute

2017 Grant Recipients

The Greenberg Bladder Cancer Institute granted three awards in 2017.

Sexual Function Outcomes and Sexual Dysfunction in Women with Bladder Cancer: a Mixed-Methods Analysis of Patient-Reported Outcomes after Radical Cystectomy for Urothelial Bladder Cancer

Sima Porten, MDSima Porten, MD
Department of Urology
University of California, San Francisco
Sumeet Bhanvadia, MD
Sumeet Bhanvadia, MD
Institute of Urology
USC Keck School of Medicine

Dr. Bhandavia (USC) and Dr. Porten (UCSF) will investigate the extent of sexual dysfunction experienced by women after radical cystectomy, and its impact on them and their partners. This will be a multi-site, mixed methods study, that seeks to understand this important domain of quality of life in an in-depth way, with the goal of improving survivorship for women with bladder cancer.

 

Nuclear receptor-activated transcriptomic signatures in human urothelium for the deconvolution of tumour transcriptomes.

Simon Baker and Jenny Southgate
Simon Baker, PhD, & Jenny Southgate, PhD
Department of Biology
University of York, UK

Although nuclear receptors (NRs) play a key role in regulating urothelial differentiation and the molecular landscape of bladder cancer, the contribution of individual NRs to downstream transcriptional networks is poorly resolved. Here we propose to generate comprehensive transcriptional subnetworks from normal human urothelial cells as a framework from which to identify and target specific cancer-related programs.

 

Understanding Sexual Dysfunction in Women with Bladder Cancer Undergoing Radical Cystectomy

Natasha GuptaNatasha Gupta, MD
Brady Urological Institute
Johns Hopkins School of Medicine

Sexual dysfunction is a significant quality of life issue among women undergoing radical cystectomy for bladder cancer. The purpose of this study is to gain an understanding of the components of sexual health and dysfunction among women undergoing radical cystectomy and to assess variations in national practice patterns among urologists regarding operative techniques that can impact sexual function in women.

 

The chromatin landscape of male and female urothelial cells

Professor Margaret KnowlesProfessor Margaret Knowles
Leeds Institute of Cancer and Pathology
St. James University Hospital, Leeds, UK

This project will investigate the regulation of gene expression in the normal bladder lining of males and females.  If fundamental gender-related differences are identified, these may contribute to the observed differences in bladder cancer incidence and in the molecular features of bladder tumors in males and females.

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