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Controlled Trials

A randomized control trial (RCT) is a scientific procedure most commonly used in testing medicines or medical procedures. It is a trial that uses randomized control. This is considered the most reliable form of scientific evidence because it eliminates all forms of cognitive bias. The basic idea is that treatments are allocated to subjects at random. This ensures that the different treatment groups are 'statistically equivalent'. 

Sellers of medicines throughout the ages have had to convince their consumers that the medicine works. As science has progressed, public expectations have risen, and government health budgets have become ever tighter, pressure has grown for a reliable system to do this. Moreover, the public's concern for the dangers of medical interventions has spurred both legislators and administrators to provide an evidential basis for licensing or paying for new procedures and medications. In the United States, new medicines must undergo trials to earn FDA approval.  Such trials are typically sponsored by the manufacturer and progress from smaller phase I and II studies designed to establish side effects and optimal dose to larger phase III studies designed to establish efficacy against placebo or against an existing drug. 

In contrast, RCTs in Hopkins GIM focus not on industry-sponsored tests of new drugs, but rather on NIH-funded tests of (a) behavioral interventions, (b) health care interventions, (c) dietary modifications, (d) low-cost minerals or food supplements, or (e) comparative efficacy between drugs already on the market.

Information about the faculty conducting randomized controlled trials and their projects is provided below.

Displaying 1 - 7 of 7 Records
Photo of Dr. Lawrence J. Appel, M.D., M.P.H.

Appel, Lawrence J., M.D., M.P.H.

Professor of Medicine
Director, Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University
The C. David Molina, M.D., M.P.H. Professor of Medicine, Epidemiology and International Health
Research Interests: Hypertension, Cardiovascular and Kidney Disease Prevention, Lifestyle Modification
 
Photo of Dr. Jeanne Marie Clark, M.D., M.P.H.

Clark, Jeanne Marie, M.D., M.P.H.

Professor of Medicine
Director, Division of General Internal Medicine
Research Interests: Obesity, Diabetes Mellitus, Nonalcoholic Fatty Liver Disease
 
Photo of Dr. Lisa Angeline Cooper, M.D., M.P.H.

Cooper, Lisa Angeline, M.D., M.P.H.

Professor of Medicine
Bloomberg Distinguished Professor, Health and Healthcare Equity
James F. Fries Professor of Medicine
Director, Johns Hopkins Center for Health Equity
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research
Research Interests: Race/ethnic health disparities, Patient-centered care, Patient-Physician relationships and communication
 
Photo of Dr. Gail Lois Daumit, M.D., M.H.S.

Daumit, Gail Lois, M.D., M.H.S.

Professor of Medicine
Joint Appointment in Psychiatry and Behavioral Sciences
Research Director, Division of General Internal Medicine
Co-Chair, Institutional Review Board X
Research Interests: Health disparities, Access to and quality of primary medical care for individuals with severe and persistent mental illness, Medical comorbidity, Epidemiology and prevention of comorbid disease in serious mental illness
 
Photo of Dr. Daniel Ernest Ford, M.D., M.P.H.

Ford, Daniel Ernest, M.D., M.P.H.

Professor of Medicine
Joint Appointment in Psychiatry and Behavioral Sciences
Director, Johns Hopkins Institute for Clinical and Translational Research
Vice Dean for Clinical Investigation
Research Interests: Epidemiology and treatment of depression, Physician health, Internet health applications, Primary care research, Tobacco use, Stroke, Information technology, Coronary artery disease, Myocardial infarction
 
Photo of Dr. Edgar Raymond Miller, III, M.D., Ph.D.

Miller, Edgar Raymond, M.D., Ph.D. III

Professor of Medicine
Deputy Director - Johns Hopkins Institute for Clinical and Translational Science, Research Clinical, Education, Training and Career Development Program
Director Clinical Research Scholars Program (KL-2), Johns Hopkins Institute for Clinical and Translational Research
Research Interests: Non-pharmacologic therapies, Hypertension, Antioxidants
 
Photo of Dr. Hsin-Chieh Yeh, Ph.D.

Yeh, Hsin-Chieh, Ph.D.

Associate Professor of Medicine
Associate Professor of Oncology
Sr. Epidemiologist, Osler Housestaff Research Program
Director, GIM Methods Core
Director, JHU-UMD Diabetes Research Center Health Care and Population Science Core
Core Faculty Member, Welch Center for Prevention, Epidemiology and Clinical Research
Research Interests: obesity and cancer, cancer epidemiology, clinical trials, racial disparity
 

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