Phenotypic Variables
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Detailed information is available on each class of phenotypic variables listed below. The phenotypes range from biomarkers to imaging and detailed incident disease information.
Criteria for adjudicating coronary disease outcomes is available beneath the table on a PDF attachmement. Please inquire for the numbers available for each phenotype as it may vary. Please address phenotype inquiries to [email protected] with a copy to [email protected].
| General Category | Brief List of Phenotypic Variables |
| Sociodemographic variables | Age, sex, race (self-report US census codes), marital status, employment status, residence, education |
| Medical history | Chronic and acute conditions; symptom check list (acute and chronic); current medications |
| Physical examination | Cardiac and chest auscultation, systems examination; xanthomas |
| Blood lipid concentrations | Total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol. NMR spectroscopy for particle size, VAP |
| Glucose and insulin concentrations | Fasting plasma glucose, fasting insulin; HOMA-IR, QUICKI |
| Inflammatory cytokines | hs-CRP, IL-6, IL-1Beta, MMP-9, MCP-1, ICAM, VCAM |
| Thrombosis and hemostasis factors | PAI-1, fibrinogen, Lp(a) |
| Platelet function | Aggregation, slope and lag time to ADP, epinephrine, collagen, arachidonic acid at different doses, pre and post Aspirin in whole blood and PRP. PFA-100. Urinary thromboxane metabolite. (over 400 platelet function phenotypes)- please inquire for full list |
| Blood counts | WBC, RBC, platelet count, hematocrit, hemoglobin, RDW |
| Anthropometrics | Waist, height, weight, BMI |
| Lifestyle risk factors | Physical activity, diet, smoking |
| Vascular properties | Brachial artery reactivity (flow-mediated dilatation), arterial stiffness, carotid distensibility, aortic pulse wave velocity, pulse pressure |
| Blood pressure | Resting, post exercise, during exercise |
| Peripheral arterial disease | Resting and post exercise ankle brachial blood pressures (ABI); PAD diagnosis |
| Coronary artery calcification (CAC) | Helical CT, Agatston Scores |
| Coronary CT angiography (with contrast) | Calcified and uncalcified plaque, percent stenosis, plaque volumetrics |
| Exercise Stress testing | Maximal symptom limited treadmill testing, MET, exercise electrocardiogram (ischemia). serial blood pressure measurements, post exercise ABI |
| Exercise nuclear perfusion imaging | Single Photon Emission Tomography (SPECT), using thallium-201 or sestamibi |
| Occult cerebrovascular disease | Cranial MRA, MRI, white matter disease volumetrics, lacunes, brain volumes, ARIC/CHS visual analogue scores |
| Incident cardiovascular and cerebrovascular disease events | Coronary disease (acute coronary syndromes, stable syndromes), interventions for CAD, stroke, TIA, PAD |
| Mental stress. other physiologic stress | Stroop color word test, cold pressor testing, heart rate variability (imited N) |
| Psychological factors | General Well-being Schedule (anxiety, depression, somaticism, chronic stress/distress), social support, religiosity, cultural identity (African Americans) |