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Phenotypic Variables

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PH001Detailed information is available on each class of phenotypic variables listed below. The phenotypes range from biomarkers to imaging and detailed incident disease information.

Criteria for adjudicating coronary disease outcomes is available beneath the table on a PDF attachmement. Please inquire for the numbers available for each phenotype as it may vary. Please address phenotype inquiries to lryanek@jhmi.edu with a copy to dbecker@jhmi.edu

General CategoryBrief List of Phenotypic Variables
Sociodemographic variablesAge, sex, race (self-report US census codes), marital status, employment status, residence, education
Medical historyChronic and acute conditions; symptom check list (acute and chronic); current medications
Physical examinationCardiac and chest auscultation, systems examination; xanthomas
Blood lipid concentrationsTotal cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol. NMR spectroscopy for particle size, VAP
Glucose and insulin concentrationsFasting plasma glucose, fasting insulin; HOMA-IR, QUICKI
Inflammatory cytokineshs-CRP, IL-6, IL-1Beta, MMP-9, MCP-1, ICAM, VCAM
Thrombosis and hemostasis factorsPAI-1, fibrinogen, Lp(a)
Platelet functionAggregation, slope and lag time to ADP, epinephrine, collagen, arachidonic acid at different doses, pre and post Aspirin in whole blood and PRP. PFA-100. Urinary thromboxane metabolite. (over 400 platelet function phenotypes)- please inquire for full list
Blood countsWBC, RBC, platelet count, hematocrit, hemoglobin, RDW
AnthropometricsWaist, height, weight, BMI
Lifestyle risk factorsPhysical activity, diet, smoking
Vascular propertiesBrachial artery reactivity (flow-mediated dilatation), arterial stiffness, carotid distensibility, aortic pulse wave velocity, pulse pressure
Blood pressureResting, post exercise, during exercise
Peripheral arterial diseaseResting and post exercise ankle brachial blood pressures (ABI); PAD diagnosis
Coronary artery calcification (CAC)Helical CT, Agatston Scores
Coronary CT angiography (with contrast)Calcified and uncalcified plaque, percent stenosis, plaque volumetrics
Exercise Stress testingMaximal symptom limited treadmill testing, MET, exercise electrocardiogram (ischemia). serial blood pressure measurements, post exercise ABI
Exercise nuclear perfusion imagingSingle Photon Emission Tomography (SPECT), using thallium-201 or sestamibi
Occult cerebrovascular diseaseCranial MRA, MRI, white matter disease volumetrics, lacunes, brain volumes, ARIC/CHS visual analogue scores
Incident cardiovascular and cerebrovascular disease eventsCoronary disease  (acute coronary syndromes, stable syndromes), interventions for CAD, stroke, TIA, PAD
Mental stress. other physiologic stressStroop color word test, cold pressor testing, heart rate variability (imited N)
Psychological factorsGeneral Well-being Schedule (anxiety, depression, somaticism, chronic stress/distress), social support, religiosity, cultural identity (African Americans)


Cardiovascular Disease Events Classification Criteria
Cardiovascular Disease Endpoints