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Mitochondrial Biology

Aged Brain

Mitochondria are the cells’ powerhouses and play a crucial role in the development of increased levels of oxidative stress and ultimately in program cell death (apoptosis). Investigators focused on aging have long hypothesized that mitochondria are of crucial importance to the evolution of aging and frail phenotypes.

Research focus

Researchers in the Johns Hopkins Division of Geriatric Medicine and Gerontology are seeking to understand the effect of mitochondrial injury as a critical part of the aging process and a potential cause for age-related diseases.

Currently, researchers are conducting studies that span the gamut from basic pathophysiology experiments in isolated mitochondria to clinical human studies aimed at elucidating the role of mitochondrial damage in aging.

They use state-of-the-art facilities and core labs that include high resolution transmission and immune electron microscope, confocal and light microscopes. An XF96 Extracellular Flux Analyzer allows researchers to simultaneously measure the two major energy yielding pathways, aerobic respiration and glycolysis.

Current research studies

  • Identification of pathological changes in mitochondria related to the renin-angiotensin system and mitophagy abnormalities and how these aging-related changes may ultimately impact frailty in late life decline
  • Mitochondria, mitophagy, and late-life decline

Faculty investigators