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Early Detection of Pancreatic Cancer Laboratory
The goal of the lab's research is to identify molecular abnormalities that can improve the outcome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer.
Thus, marker efforts have been focused mostly on identifying markers of advanced precancerous neoplasia (PanINs and IPMNs) that could improve our ability to effectively screen patients at risk of developing pancreatic cancer. We lead or participate in a number of clinical research protocols involved in the screening and early detection of pancreatic neoplasia including the CAPS clinical trials. We maintain a large repository of specimens from cases and controls with and without pancreatic disease and use this repository to investigate candidate markers of pancreatic cancer for their utility to predict pancreatic cancer risk.
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In addition, we have been working to identify familial pancreatic cancer susceptibility genes and identified BRCA2 as a pancreatic cancer susceptibility gene in 1996. We participate in the PACGENE consortium and the familial pancreatic cancer sequencing initiative. My lab also investigates pancreatic cancer genetics, epigenetics, molecular pathology, tumor stromal interactions and functional analysis of candidate genes and miRNAs. Dr. Goggins is the principal investigator of a phase I/II clinical trial evaluating the Parp inhibitor, olaparib along with irinotecan and cisplatin for patients with pancreatic cancer. view more -
Elham Afghani Lab
The Elham Afghani Lab performs clinical research on pancreatic auto islet transplants, pancreatic cancer, pancreatic cysts, and pancreatitis.
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Florin Selaru Lab
Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.
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Gerard E. Mullin Lab
The Gerard E. Mullin Lab studies nutrition and the way that diet affects weight loss. In particular, we study how having an imbalanced gut microbiome may prevent weight loss in certain people.
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GI Biomarkers Laboratory
The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.
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Huimin Yu Lab
the Yu Lab does basic, translational and clinical research on Inflammatory Bowel Disease.
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James Hamilton Lab
The main research interests of the James Hamilton Lab are the molecular pathogenesis of hepatocellular carcinoma and the development of molecular markers to help diagnose and manage cancer of the liver. In addition, we are investigating biomarkers for early diagnosis, prognosis and response to various treatment modalities. Results of this study will provide a molecular classification of HCC and allow us to identify targets for chemoprevention and treatment. Specifically, we extract genomic DNA and total RNA from liver tissues and use this genetic material for methylation-specific PCR (MSP), cDNA microarray, microRNA microarray and genomic DNA methylation array experiments.
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Jeanne Clark Lab: GIM Research
Research in the Jeanne Clark Lab covers a wide range of fields, employing various research techniques, methods and procedures to generate and disseminate the knowledge required to prevent disease and its consequences. Our most recent research program, Look AHEAD, focuses on the health of overweight volunteers with type 2 diabetes. We are examining the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity.
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Jennifer Foulke-Abel Lab
The Jennifer Foulke-Abel Lab performs basic and translational research on Infectious Diarrheal Diseases.
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Joanna Melia Lab
The performs basic, translational, and clinical research on Zinc metabolism and inflammatory bowel disease.
