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Ongoing Research in Gastroenterology and Hepatology

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  • Aline Charabaty Lab

    The Aline Charabaty Lab performs clinical research on Inflammatory Bowel Disorder.

    Research Areas: Inflammatory Bowel Disorder

    Principal Investigator

    Aline Charabaty Pishvaian, M.D.

    Department

    Medicine

  • Alyssa Parian Lab

    The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations.

    Research Areas: inflammatory bowel disease, cancer, displaysia

    Principal Investigator

    Alyssa Parian, M.D.

    Department

    Medicine

  • Amy Kim Lab

    The Amy Kim Lab performs basic, translational, and clinical research on liver lesions and hepatocellular carcinoma.

    Research Areas: Liver lesions, hepatocellular carcinoma

    Principal Investigator

    Amy K. Kim, M.D.

    Department

    Medicine

  • Anne Marie Lennon Lab

    The Lennon Lab does clinical and translational research on endoscopic ultrasound, esophageal cancer, gastric cancer, gastroenterology, pancreatic cancer, pancreatic cysts, therapeutic endoscopy, Von Hippel-Lindau (VHL)

    Research Areas: Von Hippel-Lindau (VHL), gastroenterology, pancreatic cancer, Endoscopic Ultrasound, Esophageal Cancer, Pancreatic Cysts, Therapeutic Endoscopy, Gastric Cancer

  • Ashish Nimgoankar Lab

    The Ashish Nimgoankar Lab is interested in translational technology development and image-guided therapies.

    Research Areas: translational technology, imaging

    Principal Investigator

    Ashish Nimgaonkar, M.B.B.S., M.D., M.S.

    Department

    Medicine

  • Brindusa Truta Lab

    The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ulcerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history.

    Research Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis

    Principal Investigator

    Brindusa Truta, M.D., M.A.S.

    Department

    Medicine

  • Center for Epithelial Disorders

    The Johns Hopkins Center for Epithelial Disorders focuses on research into the physiology and pathophysiology of epithelial cells (cells that line the cavities and interior surfaces of the body) of the gastrointestinal (GI) tract, liver, pancreas and kidney. Specifically, the center’s research seeks to:

    -Understand the mechanisms regulating the activity of transport proteins (including channels) of epithelial cells
    Characterize the mechanisms by which polarity of epithelial cells are maintained
    -Investigate the mechanisms controlling transcription of epithelial-specific genes
    Understand the pathophysiological basis of GI and renal diseases that involve the preceding three components
    -The center also provides a framework for training fellows in gastroenterology and hepatology to become independent investigators.

    The center is funded primarily through individual investigator-initiated extramural research grant support from the National Institutes of Health (NIH) as well as mult...i-investigator grants including RO1, PO1, UO1 and R24. view more

    Research Areas: gastroenterology, epithelial cells

    Principal Investigator

    Mark Donowitz, M.D.

    Department

    Medicine
    Physiology

  • Chung-Ming Tse

    The Tse Lab does basic and translational research on the function and regulation of sodium/hydrogen exchange-2 isoform, and molecular biology of nucleoside transporters.

    Research Areas: Function and regulation of sodium/hydrogen exchange-2 isoform, molecular biology of nucleoside transporters

    Principal Investigator

    Ming-Tseh Lin, M.D., Ph.D.

    Department

    Medicine

  • Cynthia Sears Laboratory

    Work in the Cynthia Sears Laboratory focuses on the bacterial contributions to the development of human colon cancer and the impact of the microbiome on other cancers and the therapy of cancer. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. Prospective human studies of the microbiome and biofilms in screening colonoscopy are in progress as are studies to determine if and how the microbiome impacts the response of individuals with cancer to immunotherapy and other cancer therapies.

    Research Areas: epidemiology, AIDS, microbiome, colon cancer, enterotoxigenic Bacteroides fragilis, chronic colonic inflammation

    Principal Investigator

    Cynthia Sears, M.D.

    Department

    Medicine
    Oncology

  • Doan Dao Lab

    The Doan Dao Lab performs clinical research on Hepatitis B.

    Research Areas: hepatitis B

    Principal Investigator

    Doan Dao, M.D.

    Department

    Medicine

  • Early Detection of Pancreatic Cancer Laboratory

    The goal of the lab's research is to identify molecular abnormalities that can improve the outcome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer.

    Thus, marker efforts have been focused mostly on identifying markers of advanced precancerous neoplasia (PanINs and IPMNs) that could improve our ability to effectively screen patients at risk of developing pancreatic cancer. We lead or participate in a number of clinical research protocols involved in the screening and early detection of pancreatic neoplasia including the CAPS clinical trials. We maintain a large repository of specimens from cases and controls with and without pancreatic disease and use this repository to investigate candidate markers of pancreatic cancer for their utility to predict pancreatic cancer risk.
    ...
    In addition, we have been working to identify familial pancreatic cancer susceptibility genes and identified BRCA2 as a pancreatic cancer susceptibility gene in 1996. We participate in the PACGENE consortium and the familial pancreatic cancer sequencing initiative. My lab also investigates pancreatic cancer genetics, epigenetics, molecular pathology, tumor stromal interactions and functional analysis of candidate genes and miRNAs. Dr. Goggins is the principal investigator of a phase I/II clinical trial evaluating the Parp inhibitor, olaparib along with irinotecan and cisplatin for patients with pancreatic cancer.
    view more

    Research Areas: pancreatic cancer

  • Elham Afghani Lab

    The Elham Afghani Lab performs clinical research on pancreatic auto islet transplants, pancreatic cancer, pancreatic cysts, and pancreatitis.

    Research Areas: pancreatic cancer, Pancreatic Auto Islet Transplant, pancreatitis, Pancreatic Cysts

    Principal Investigator

    Elham Afghani, M.D., M.P.H.

    Department

    Medicine

  • Florin Selaru Lab

    Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.

    Research Areas: gastroenterology, cancer, inflammation, molecular biology

    Principal Investigator

    Florin Selaru, M.D.

    Department

    Medicine
    Oncology

  • Gerard E. Mullin Lab

    The Gerard E. Mullin Lab studies nutrition and the way that diet affects weight loss. In particular, we study how having an imbalanced gut microbiome may prevent weight loss in certain people.

    Research Areas: gut bacteria, nutrition, gut microbiota, obesity, weight loss

    Principal Investigator

    Gerard Mullin, M.D., M.S.

    Department

    Medicine

  • GI Biomarkers Laboratory

    The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.

    Research Areas: gastrointestinal system, translational research in Barrett’s esophagus-associated neoplastic progression, Molecular pathophysiology, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis

    Principal Investigator

    Stephen Meltzer, M.D.

    Department

    Medicine
    Oncology

  • Huimin Yu Lab

    the Yu Lab does basic, translational and clinical research on Inflammatory Bowel Disease.

    Research Areas: inflammatory bowel disease

    Principal Investigator

    Huimin Yu, B.M., M.D., Ph.D.

    Department

    Medicine

  • James Hamilton Lab

    The main research interests of the James Hamilton Lab are the molecular pathogenesis of hepatocellular carcinoma and the development of molecular markers to help diagnose and manage cancer of the liver. In addition, we are investigating biomarkers for early diagnosis, prognosis and response to various treatment modalities. Results of this study will provide a molecular classification of HCC and allow us to identify targets for chemoprevention and treatment. Specifically, we extract genomic DNA and total RNA from liver tissues and use this genetic material for methylation-specific PCR (MSP), cDNA microarray, microRNA microarray and genomic DNA methylation array experiments.

    Research Areas: Copper homeostasis, Wilson's disease, cancer, molecular genetics, Early detection biomarker discovery for hepatocellular carcinoma, genomics, pathogenesis, liver injury, liver diseases, regulation of lipid metabolism, hepatocellular carcinoma, Pathogenesis of Liver fibrosis and cancer

    Principal Investigator

    James Hamilton, M.D.

    Department

    Medicine

  • Jeanne Clark Lab: GIM Research

    Research in the Jeanne Clark Lab covers a wide range of fields, employing various research techniques, methods and procedures to generate and disseminate the knowledge required to prevent disease and its consequences. Our most recent research program, Look AHEAD, focuses on the health of overweight volunteers with type 2 diabetes. We are examining the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity.

    Research Areas: epidemiology, diabetes mellitus, obesity, diabetes, Nonalcoholic Fatty Liver Disease, liver diseases

    Lab Website

    Principal Investigator

    Jeanne Clark, M.D., M.P.H.

    Department

    Medicine

  • Jennifer Foulke-Abel Lab

    The Jennifer Foulke-Abel Lab performs basic and translational research on Infectious Diarrheal Diseases.

    Research Areas: Infectious Diarrheal Diseases

    Principal Investigator

    Jennifer Foulke-Abel, Ph.D.

    Department

    Medicine

  • Joanna Melia Lab

    The performs basic, translational, and clinical research on Zinc metabolism and inflammatory bowel disease.

    Research Areas: inflammatory bowel disease, Zinc metabolism

    Principal Investigator

    Joanna Melia, M.D.

    Department

    Medicine

  • Ken Hui Lab

    The Hui lab performs basic, translational and clinical research on genetics and genomics of neurogastroenterological disorders.

    Research Areas: Genetics and genomics of neurogastroenterological disorders

    Principal Investigator

    Ken Hui, M.D., Ph.D.

    Department

    Medicine

  • Liudmila Cebotaru Lab

    Research in the Liudmila Cebotaru Lab studies cystic fibrosis transmembrane conductance regulator (CFTR) mutants. We also investigate corrector molecules that are currently in clinical trials to get a better understanding of their mechanism of action. A major focus of our research is on developing more efficient gene therapy vectors with the ultimate goal of developing a gene therapy for cystic fibrosis.

    Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, corrector molecules

    Principal Investigator

    Liudmila Cebotaru, M.D., J.D.

    Department

    Medicine
    Physiology

  • Marcia Canto Lab

    Research interests in the Marcia Canto Lab include pancreatic neoplasms, Barrett’s esophagus and endomicroscopy. We are also interested in the use of endoscopic ultrasound to identify early-stage pancreatic cancer and its precursors.

    Research Areas: endomicroscopy, Esophageal Disorders, pancreatic cancer, endoscopy, Barrett's esophagus

    Principal Investigator

    Marcia Canto, M.D., M.H.S.

    Department

    Medicine

  • Mark Lazarev Lab

    The Mark Lazarev Lab performs clinical research on Inflammatory Bowel Disease.

    Research Areas: inflammatory bowel disease

    Principal Investigator

    Mark Lazarev, M.D.

    Department

    Medicine

  • Mark Sulkowski Lab

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

    Research Areas: infectious disease, hepatitis B, hepatitis C

    Lab Website

    Principal Investigator

    Mark Sulkowski, M.D.

    Department

    Medicine

  • Michael Goggins Lab

    The Michael Goggins Lab performs basic, translational, and clinical research on pancreatic cancer.

    Research Areas: pancreatic cancer

  • Mouen Khashab Lab

    The Mouen Khashab Lab performs clinical research on spasmatic esophageal disorders and endoscopic myotomy.

    Research Areas: spasmatic esophageal disorders, endoscopic myotomy

    Principal Investigator

    Mouen Khashab, M.D.

    Department

    Medicine

  • Nicholas Zachos Lab

    Researchers in the Nicholas Zachos Lab work to understand variations in protein trafficking that occur during pathophysiological conditions that cause ion and water transport that result in diarrhea. We recently identified a clathrin-independent endocytic pathway responsible for elevated intracellular calcium-mediated inhibition of NHE3 activity in intestinal epithelial cells. We use advanced imaging techniques, including confocal and multi-photon microscopy, to characterize protein trafficking of intestinal transporters. We also perform functional assays using fluorescent probes (ratiometric and non-ratiometric) to measure ion transport in cell culture models, intact intestinal tissues and human small intestinal enteroids.

    Research Areas: imaging, protein trafficking, diarrhea, bioinformatics, molecular biology

    Principal Investigator

    Nicholas Zachos

    Department

    Medicine

  • Pankaj Jay Pasricha Lab

    Researchers in the Pankaj Jay Pasricha Lab are interested in the molecular mechanisms of visceral pain and restoration of enteric neural function with novel strategies, including neural stem cell transplants. Recent research has focused on the enteric nervous system and gut-brain axis, and the complexity of pain in chronic pancreatitis. Another recent study indicates that patients with underlying small intestinal bacterial overgrowth have significant delays in small bowel transit time as compared to those without, while another explored the safety and efficacy of carbon dioxide cryotherapy for treatment of neoplastic Barrett's esophagus.

    Research Areas: gastroenterology, stem cells, neurogastroenterology, pancreatitis, pain, Barrett's esophagus, motility disorders

    Principal Investigator

    Jay Pasricha

    Department

    Medicine

  • Reezwana Chowdhury Lab

    The Reezwana Chowdhury Lab performs clinical research on Inflammatory Bowel Disorder and colorectal cancer.

    Research Areas: Inflammatory Bowel Disorder, colorectal cancer

    Principal Investigator

    Reezwana Chowdhury, M.D.

    Department

    Medicine

  • Robert Bulat Lab

    The Robert Bulat Lab performs clinical research on gastroparesis and other motility disorders.

    Research Areas: motility disorders, Gastroparesis

    Principal Investigator

    Robert Bulat, M.D., Ph.D., M.Sc.

    Department

    Medicine

  • Saleh Alqahtani Lab

    The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver disease and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients.

    Research Areas: fatty liver disease, Hepatitis, hepatitis B, liver transplants, cirrhosis, Drug Induced Liver Injury, hepatitis C, liver diseases, liver cancer

    Principal Investigator

    Saleh Alqahtani, M.B.Ch.B., M.S.

    Department

    Medicine

  • Saowanee Ngamruengphong Lab

    Research in the Saowanee Ngamruengphong Lab focuses on methods for diagnosing and managing gastrointestinal conditions, including premalignant and malignant lesions of the gastrointestinal tract, esophageal cancer, colon polyps, and biliary and pancreatic disease. Our most recent work includes investigating a novel hybrid technique for closure of refractory gastrocutaneous fistula. We also conducted an international multicenter study that compared endoscopic ultrasound-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography following Whipple surgery.

    Research Areas: Endoscopic mucosal resection/endoscopic submucosal dissection, colon polyps, cancer, endoscopy, pancreatic disease, gastric cancer, ultrasound, gastrointestinal

    Principal Investigator

    Saowanee Ngamruengphong, M.D.

    Department

    Medicine

  • Shaoyong Yu Lab

    The Yu Lab does basic and translational research on Sensory physiology and disorders of the gastrointestinal tract.

    Research Areas: Sensory physiology and disorders of the gastrointestinal tract

    Principal Investigator

    Shaoyong Yu, M.D.

    Department

    Medicine

  • Subhash Kulkarni Lab

    The Subhash Kulkarni Lab performs basic and translational research on disorders of neurogastroenterology and motility.

    Research Areas: Disorders of neurogastroenterology and motility

    Lab Website

    Principal Investigator

    Subhash Kulkarni

    Department

    Medicine

  • Svetlana Lutsenko Laboratory

    The research in the Svetlana Lutsenko Laboratory is focused on the molecular mechanisms that regulate copper concentration in normal and diseased human cells.

    Copper is essential for human cell homeostasis. It is required for embryonic development and neuronal function, and the disruption of copper transport in human cells results in severe multisystem disorders, such as Menkes disease and Wilson's disease.

    To understand the molecular mechanisms of copper homeostasis in normal and diseased human cells, we utilize a multidisciplinary approach involving biochemical and biophysical studies of molecules involved in copper transport, cell biological studies of copper signaling, and analysis of copper-induced pathologies using Wilson's disease gene knock-out mice.

    Research Areas: biophysics, biochemistry, menkes disease, Wilson's disease, cell biology, multisystem disorders, Ion transport, physiology, trafficking assembly regulation, copper, molecular biology

    Lab Website

    Principal Investigator

    Svetlana Lutsenko, Ph.D.

    Department

    Medicine
    Physiology

  • Tinsay Woreta

    The Woreta Lab does clinical and translational research on Hepatocellular Carcinoma; Liver Transplantation Outcomes; Chronic Viral Hepatitis.

    Research Areas: Chronic Viral Hepatitis, Liver Transplantation Outcomes, hepatocellular carcinoma

    Principal Investigator

    Tinsay Woreta, M.D., M.P.H.

    Department

    Medicine

  • Tsion Abdi Lab

    The Tsion Abdi Lab performs clinical research on Scleroderma Bowel Disease and Inflammatory Bowel Disease.

    Research Areas: inflammatory bowel disease, Scleroderma Bowel Disease

    Principal Investigator

    Tsion Abdi, M.D., M.P.H.

    Department

    Medicine

  • Varsha Singh

    The Singh Lab does basic and translational research on intestinal ion transport, cellular physiology, and membrane trafficking in diabetic disorders.

    Research Areas: Intestinal ion transport, cellular physiology, membrane trafficking in diabetic disorders

    Principal Investigator

    Varsha Singh, Ph.D.

    Department

    Medicine

  • Victor Chen Lab

    The Victor Chen Lab performs clinical research on alcohol use disorder, alcohol-associated liver disease, and transplantation.

    Research Areas: transplantation, alcohol use disorder, alcohol-associated liver disease

    Principal Investigator

    Victor Chen, M.D.

    Department

    Medicine

  • Vikesh Singh

    The Singh lab does clinical and translational research on pancreatic islet isolation and transplantation as well as acute and chronic pancreatitis.

    Research Areas: Pancreatic islet isolation and transplantation, pancreatitis

    Principal Investigator

    Vikesh Singh, M.D., M.Sc.

    Department

    Medicine

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