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Ken Hui Lab
The Hui lab performs basic, translational and clinical research on genetics and genomics of neurogastroenterological disorders.
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Liudmila Cebotaru Lab
Research in the Liudmila Cebotaru Lab studies cystic fibrosis transmembrane conductance regulator (CFTR) mutants. We also investigate corrector molecules that are currently in clinical trials to get a better understanding of their mechanism of action. A major focus of our research is on developing more efficient gene therapy vectors with the ultimate goal of developing a gene therapy for cystic fibrosis.
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Marcia Canto Lab
Research interests in the Marcia Canto Lab include pancreatic neoplasms, Barrett’s esophagus and endomicroscopy. We are also interested in the use of endoscopic ultrasound to identify early-stage pancreatic cancer and its precursors.
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Mark Lazarev Lab
The Mark Lazarev Lab performs clinical research on Inflammatory Bowel Disease.
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Mark Sulkowski Lab
Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.
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Michael Goggins Lab
The Michael Goggins Lab performs basic, translational, and clinical research on pancreatic cancer.
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Mouen Khashab Lab
The Mouen Khashab Lab performs clinical research on spasmatic esophageal disorders and endoscopic myotomy.
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Nicholas Zachos Lab
Researchers in the Nicholas Zachos Lab work to understand variations in protein trafficking that occur during pathophysiological conditions that cause ion and water transport that result in diarrhea. We recently identified a clathrin-independent endocytic pathway responsible for elevated intracellular calcium-mediated inhibition of NHE3 activity in intestinal epithelial cells. We use advanced imaging techniques, including confocal and multi-photon microscopy, to characterize protein trafficking of intestinal transporters. We also perform functional assays using fluorescent probes (ratiometric and non-ratiometric) to measure ion transport in cell culture models, intact intestinal tissues and human small intestinal enteroids.
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Pankaj Jay Pasricha Lab
Researchers in the Pankaj Jay Pasricha Lab are interested in the molecular mechanisms of visceral pain and restoration of enteric neural function with novel strategies, including neural stem cell transplants. Recent research has focused on the enteric nervous system and gut-brain axis, and the complexity of pain in chronic pancreatitis. Another recent study indicates that patients with underlying small intestinal bacterial overgrowth have significant delays in small bowel transit time as compared to those without, while another explored the safety and efficacy of carbon dioxide cryotherapy for treatment of neoplastic Barrett's esophagus.
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Reezwana Chowdhury Lab
The Reezwana Chowdhury Lab performs clinical research on Inflammatory Bowel Disorder and colorectal cancer.
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Robert Bulat Lab
The Robert Bulat Lab performs clinical research on gastroparesis and other motility disorders.
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Saleh Alqahtani Lab
The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver disease and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients.
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Saowanee Ngamruengphong Lab
Research in the Saowanee Ngamruengphong Lab focuses on methods for diagnosing and managing gastrointestinal conditions, including premalignant and malignant lesions of the gastrointestinal tract, esophageal cancer, colon polyps, and biliary and pancreatic disease. Our most recent work includes investigating a novel hybrid technique for closure of refractory gastrocutaneous fistula. We also conducted an international multicenter study that compared endoscopic ultrasound-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography following Whipple surgery.
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Shaoyong Yu Lab
The Yu Lab does basic and translational research on Sensory physiology and disorders of the gastrointestinal tract.
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Subhash Kulkarni Lab
The Subhash Kulkarni Lab performs basic and translational research on disorders of neurogastroenterology and motility.
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Svetlana Lutsenko Laboratory
The research in the Svetlana Lutsenko Laboratory is focused on the molecular mechanisms that regulate copper concentration in normal and diseased human cells.
Copper is essential for human cell homeostasis. It is required for embryonic development and neuronal function, and the disruption of copper transport in human cells results in severe multisystem disorders, such as Menkes disease and Wilson's disease.
To understand the molecular mechanisms of copper homeostasis in normal and diseased human cells, we utilize a multidisciplinary approach involving biochemical and biophysical studies of molecules involved in copper transport, cell biological studies of copper signaling, and analysis of copper-induced pathologies using Wilson's disease gene knock-out mice. -
Tinsay Woreta
The Woreta Lab does clinical and translational research on Hepatocellular Carcinoma; Liver Transplantation Outcomes; Chronic Viral Hepatitis.
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Tsion Abdi Lab
The Tsion Abdi Lab performs clinical research on Scleroderma Bowel Disease and Inflammatory Bowel Disease.
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Varsha Singh
The Singh Lab does basic and translational research on intestinal ion transport, cellular physiology, and membrane trafficking in diabetic disorders.
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Victor Chen Lab
The Victor Chen Lab performs clinical research on alcohol use disorder, alcohol-associated liver disease, and transplantation.
