Dr. Garcia currently has several on-going research projects. His interests include: exploring the role of cholesterol in human female infertility, fertility preservation for cancer patients, luteal phase endometrial markers following ovarian hyperstimulation, the role of nitric oxide in embryonic development (working with Dr. Lipari), optimal stimulation protocols for the patient with decreased ovarian reserve, GnRH antagonist initiation day and duration, and SR-B1 (cholesterol receptor) expression in human placental tissue.
Reproductive Outcomes in Salon Employees (ROSE)
This study looks at menstrual and fertility history as related to work history in women working outside the home. In addition, it includes an assessment of chemical exposure in salon workers to determine if there is any increased impact on fertility and/or birth defects in those women. The study will look at questionnaires completed by 2000 working women in the Baltimore area and results of blood tests and ultrasounds in 90 of them. The study is sponsored by the Center for Disease Control and the National Institute of Occupational Safety and Health.
Risk Factors for Hot Flashes in Mid-life women
This National Institutes of Health study began in 2001. It is designed to evaluate various risk factors for hot flashes and other health-related issues associated with mid-life in women. It involves clinic visits, blood tests and telephone follow-up several times a year. The study has looked specifically at the relationship of such things as weight, smoking, race, alcohol consumption, mood and genetic factors as they relate to hot flashes and quality of life. Over 600 women in the Baltimore area have taken part in this study.
Embryo Cryopreservation project
Dr. Wallach is a co-principle investigator in a project to evaluate the attitudes of couples who have their own cryopreserved embryos. The objective is ultimately to enable Assisted Reproductive Technology programs to help couples make more informed decisions regarding their own care and also to assist public policy makers in developing recommendations that are informed by patients' experiences, insights and concerns. This goal is being accomplished through a multi-center consortium which is evaluating couples' attitudes towards having cryopreserved embryos via a self-administered questionnaire. Dr. Carolyn Alexander is assisting in the project, representing our program in this endeavor.