Regeneration of palmo/plantar type skin at the stump site in amputees
The goal of this project is to understand the normal means where dermal cells control epidermal function, especially in the case of volar skin. We also will test the capacity of dermal stem cells to actively alter skin identity in human subjects in clinical trials.
Mechanisms which control hair follicle de novo organogenesis in adulthood
The human body has programs used in development to make all the structures of the body. Can those programs be reactivated in adulthood? This would solve considerable morbidity of human disease. In this project we are trying to understand the factors which control the recapitulation of embryogenesis and creation of entirely new hair follicles during wound healing. How can we promote regeneration over scarring?
Prostaglandins in hair cycling and stem cell activity
Prostaglandins have been appreciated in the past to influence regeneration (Brown et al., 2007) and stem cell function (North et al., 2007). A central focus of the laboratory is to understand how prostaglandins regulate hair follicle cycling between growth (anagen), apoptosis (catagen), or resting (telogen) phases.
Prostaglandins in wound healing
Prostaglandins have been appreciated for a long amount of time to be present in wound healing. However, the specific role of individual prostaglandins in regulating specific cells during wound healing is less well known. Through the study of novel models of wound healing and regeneration in gain of function and loss of function mice, we hope to characterize the exact role of prostaglandins in mediating their effects.
Stem cell cellular therapy/regenerative medicine
One promise of stem cell therapy for skin is the enhancement of regeneration. A final project asks how prostaglandin modulation of therapeutic populations might enhance their effect.