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Meningioma Research

In addition to diagnosing and treating meningiomas, the experts of the Johns Hopkins Meningioma Center are leading research that is redefining the understanding of these brain tumors, their origins and directions for future treatment, including immunotherapy.


Patient-specific 3-dimensionally Printed Models for Neurosurgical Planning and Education

Panesar SS, Magnetta M, Mukherjee D, Abhinav K, Branstetter BF, Gardner PA, Iv M, Fernandez-Miranda JC. Patient-specific 3-dimensionally printed models for neurosurgical planning and education. Neurosurg Focus. 2019 Dec 1;47(6):E12. doi: 10.3171/2019.9.FOCUS19511. PMID: 31786547.
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Endoscopic Endonasal Versus Transcranial Approach to Resection of Olfactory Groove Meningiomas: A Systematic Review

Purohit A, Jha R, Khalafallah AM, Price C, Rowan NR, Mukherjee D. Endoscopic endonasal versus transcranial approach to resection of olfactory groove meningiomas: a systematic review. Neurosurg Rev. 2019 Nov 10. doi: 10.1007/s10143-019-01193-2. Epub ahead of print. PMID: 31709465.
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Metastatic atypical and anaplastic meningioma: A case series and review of the literature.

Kessler RA, Tomas Garzon-Muvdi T, Yang W, Weingart J, Olivi A, Huang J, Brem H, Lim M. World Neurosurg. 2017.
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NY-ESO-1 expression inm meningioma suggests a rationale for new immunotherapeutic approaches.

Baia GS, Caballero OL, Ho JS, Zhao Q, Cohen T, Binder ZA, Salmasi V, Gallia GL, Quinones-Hinojosa A, Olivi A, Brem H, Burger P, Strausberg RL, Simpson AJ, Eberhart CG, Riggins GJ. Cancer Immunol Res. 2013 Nov;1(5):296-302. doi: 10.1158/2326-6066.CIR-13-0029.
Epub 2013 Aug 5. PMID:24777967
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Yes-associated protein 1 is activated and functions as an oncogene in meningiomas.

Baia GS, Caballero OL, Orr BA, Lal A, Ho JS, Cowdrey C, Tihan T, Mawrin C, Riggins GJ. 
Mol Cancer Res. 2012 Jul;10(7):904-13. doi: 10.1158/1541-7786.MCR-12-0116. 
Epub 2012 May 22. PMID:22618028
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Meningioma transcript profiles reveal deregulated notch signaling pathway. 

Cuevas IC, Slocum AL, Jun P, Costello JF, Bollen AW, Riggins GJ, McDermott MW, Lal A. 
Cancer Res. 2005 Jun 15;65(12
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Clinical features of sellar and suprasellar meningiomas. Kwancharoen R, Blitz AM, Tavares F, Caturegli P, Gallia GL, Salvatori R.
Pituitary. 2014 Aug;17(4):342-8. doi: 10.1007/s11102-013-0507-z. 
PMID: 23975080
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Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor.

Guaraldi F, Corazzini V, Gallia GL, Grottoli S, Stals K, Dalantaeva N, Frohman LA, Korbonits M, Salvatori R.
Pituitary. 2012 Dec;15 Suppl 1:S61-7. doi: 10.1007/s11102-012-0391-y.
PMID: 22527616
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Perioperative and long-term outcomes from the management of parasagittal meningiomas invading the superior sagittal sinus.

Raza SM, Gallia GL, Brem H, Weingart JD, Long DM, Olivi A.
Neurosurgery. 2010 Oct;67(4):885-93; discussion 893. doi: 10.1227/NEU.0b013e3181ef2a18.
PMID: 20802356
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Regression of intracranial meningioma following intratumoral hemorrhage.

de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H.
J Clin Neurosci. 2009 Sep;16(9):1246-9. doi: 10.1016/j.jocn.2008.11.017. Epub 2009 Jun 26.
PMID: 19560362
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A rare infectious presentation of a temporal bone meningioma.

Qureshi A, Quinones-Hinojosa A, Ziai W.J
Neurooncol. 2014 Feb;116(3):633-4. doi: 10.1007/s11060-013-1319-8.
Epub 2013 Dec 12. No abstract available.
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Predictors of visual outcome following surgical resection of medial sphenoid wing meningiomas.

Chaichana KL, Jackson C, Patel A, Miller NR, Subramanian P, Lim M, Gallia G, Olivi A, Weingart J, Brem H, Quiñones-Hinojosa A.
J Neurol Surg B Skull Base. 2012 Oct;73(5):321-6. doi: 10.1055/s-0032-1321510.
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Indocyanine green for vessel identification and preservation before dural opening for parasagittal lesions.

Jusué-Torres I, Navarro-Ramírez R, Gallego MP, Chaichana KL, Quiñones-Hinojosa A.
Neurosurgery. 2013 Dec;73(2 Suppl Operative):ons145; discussion ons145. doi: 10.1227/NEU.0000000000000028.
No abstract available.
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Seizure control for patients undergoing meningioma surgery.

Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quiñones-Hinojosa A.
World Neurosurg. 2013 Mar-Apr;79(3-4):515-24. doi: 10.1016/j.wneu.2012.02.051. Epub 2012 Mar 30.
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Harvey Cushing's early treatment of meningiomas: the untold story.

Pendleton C, Olivi A, Brem H, Quiñones-Hinojosa A.
World Neurosurg. 2013 Jul-Aug;80(1-2):217-21. doi: 10.1016/j.wneu.2011.08.021. Epub 2011 Nov 7.
PMID: 22120300
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Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients.

Grossman R, Mukherjee D, Chang DC, Bennett R, Brem H, Olivi A, Quiñones-Hinojosa A.
World Neurosurg. 2011 Feb;75(2):279-85. doi: 10.1016/j.wneu.2010.09.003.
PMID: 21492731
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FACT-MNG: tumor site specific web-based outcome instrument for meningioma patients.

Zlotnick D, Kalkanis SN,Quinones-Hinojosa A, Chung K, Linskey ME, Jensen RL, DeMonte F, Barker FG, Racine CA, Berger MS, Black PM, Cusimano M, Sekhar LN, Parsa A, Aghi M, McDermott MW.
J Neurooncol. 2010 Sep;99(3):423-31. doi: 10.1007/s11060-010-0394-3. Epub 2010 Sep 18.Review.
PMID: 20853019
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The extended retrosigmoid approach for neoplastic lesions in the posterior fossa: technique modification.

Raza SM, Quinones-Hinojosa A.
Neurosurg Rev. 2011 Jan;34(1):123-9. doi: 10.1007/s10143-010-0284-3. Epub 2010 Sep 14.
PMID: 20838839 
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The supraorbital craniotomy for access to the skull base and intraaxial lesions: a technique in evolution.

Raza SM, Garzon-Muvdi T, Boaehene K, Olivi A, Gallia G, Lim M, Subramanian P, Quinones-Hinojosa A.
Minim Invasive Neurosurg. 2010 Feb;53(1):1-8. doi: 10.1055/s-0030-1247504. Epub 2010 Apr 7.
PMID: 20376737
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Technical note: Orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies.

Ruzevick J, Raza SM, Recinos PF, Chaichana K, Pradilla G, Kim JE, Olivi A, Weingart J, Evans J, Quinones-Hinojosa A, Lim M.
Clin Neurol Neurosurg. 2015 Jul;134:24-7. doi: 10.1016/j.clineuro.2015.04.005. Epub 2015 Apr 13.
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Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors.

Quiñones-Hinojosa A, Chang EF, Chaichana KL, McDermott MW.
Neurosurgery. 2009 May;64(5 Suppl 2):260-8; discussion 268. doi: 10.1227/01.NEU.0000344642.98597.A7.
PMID: 19287325
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Book Chapters

  1. Lim M. Parasagittal and Convexity Meningiomas. Fundamentals of Operative Techniques in Neurosurgery. Connolly ES, McKhann II GM, Huang J, Choudhri TF. New York. Thieme. 2010:183-185.
  2. Lim M, Frazier J. Foramen Magnum Meningiomas. Fundamentals of Operative Techniques in Neurosurgery. Connolly ES, McKhann II GM, Huang J, Choudhri TF. New York. Thieme. 2010:186-188.
  3. Bruce JN, Lim M. Tentorial Meningiomas. Fundamentals of Operative Techniques in Neurosurgery.Connolly ES, McKhann II GM, Huang J, Choudhri TF. New York. Thieme. 2010:201-204.
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