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History of the Brady Urological Institute
For over a century, the Brady Urological Institute has led the world in urologic care, research and education. Since our founding, we’ve continued to be the epicenter of all things urology. We’ve pioneered some of the most impactful discoveries in the field, including the nerve-sparing prostatectomy and the first human gene mutation in prostate cancer. Our fabled history includes titans in the field of urology, like Hugh Hampton Young, William W. Scott and Patrick C. Walsh. Meet the department and research directors who have shaped our course:
Patrick C. Walsh
Dr. Patrick Walsh is recognized as a world leader for his pioneering work in prostate cancer diagnosis and treatment. He served as the professor and director of the Brady Urological Institute for over 30 years. He is best known for the development of the anatomic approach to radical prostatectomy, which involves nerve-sparing techniques that have reduced the probability of impotence and incontinence.
He has also made major contributions to the basic understanding of benign and malignant neoplasms of the prostate. Along with co-workers, he was the first to describe the 5 alpha-reductase enzyme deficiency, develop an experimental technique for the induction of benign prostatic hyperplasia, demonstrate the influence of reversible androgen deprivation on BPH and characterize hereditary prostatic cancer.
He has served on numerous editorial boards and has authored several best-selling, easy-to-read guides for those battling prostate cancer.
William W. Scott
Dr. William Scott is credited with introducing basic science to the field of urology. His ability to fuse patient care with research transformed how urological conditions were understood and treated.
His approach to urology is best summarized by longtime colleague Don Coffey, who noted: “They gave you a key to the OR, a key to the laboratory, a key to the library, and you were told to ‘come back in four years and tell me what you learned.’”
Under his leadership, education evolved at the Brady Urological Institute. Residents were expected to take responsibility for their own education; exhibit initiative, dedication and drive for excellence; and seek achievement. Dr. Scott was a passionate teacher who knew all of his residents, their spouses and their children.
Hugh H. Young
Dr. Hugh Hampton Young is widely regarded as the father of modern urology. Among many groundbreaking milestones, he is credited with beginning the country's premier urology residency and achieving the first-ever cure for prostate cancer—with radical perineal prostatectomy, a surgical procedure he invented.
Dr. Young was a visionary of the field: Long before the importance of early detection was widely known, he advocated for screening. He developed novel techniques to remove cancer and was among the first to use radiation therapy to treat urological diseases.
With the help of one grateful patient, Jim Buchanan Brady, Dr. Young created the country’s first dedicated urological research hospital.
Past Research Chairmen
Donald S. Coffey
Director of Research
Donald Coffey is a gifted mentor and brilliant scientist who led research at the Brady Urological Institute for over three decades.
His storied legacy includes some of the field’s most significant discoveries, such as the nuclear matrix of cells.
But among his numerous achievements, the most important is that he attracted, inspired and trained countless students. “Today, when one looks at the leaders in urological research, every one of them has the imprint of Don Coffey, one way or another,” says Alan Partin, director of the Brady Urological Institute.
Director of Research
Charles Tesar ushered in a new era of scientific breakthroughs by designing and planning what a modern lab should look like.
During his time as the laboratory director, he trained and supported over 50 budding investigators. Additionally, he came to be known as a talented cartoonist, sharing his wonderful sense of humor with his colleagues.
Honors he was awarded during his long and fruitful career include a research fellowship at the Columbia University College of Physicians and Surgeons, a senior Fulbright Scholar Program grant for the Jules Bordet Institute in Belgium and a fellowship at the American Association for the Advancement of Science in Washington, D.C.
Director of Research
H.G. Williams-Ashman helped research flourish at the Brady Urological Institute. As the first research director, he established Brady’s international reputation as a scientific powerhouse.
The principal research advances made by Williams-Ashman and his coworkers over the five-year period from 1964 to 1969 were polyamine metabolism in the prostate gland and other mammalian organs; deoxyribonucleic acid synthesis in testis and prostate; hormonal regulation of protein synthesis; mechanisms of semen coagulation; and studies on male accessory genital gland metabolism, including fructose and nucleotide.
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