Skip Navigation


AHRQ Safety Program for Improving Antibiotic Use

patient in bed

Preventing patient harms today. Preserving antibiotics for tomorrow.

Antibiotics are a precious resource and can be critical for improving the outcomes of patients with certain infections. However, these medications also have the potential to cause patient harms, including allergic reactions, Clostridium difficile infections and antibiotic resistance both at the individual level and for society as a whole. For antibiotics to be effective for future generations, they must be used judiciously.

Through a contract awarded by the Agency for Healthcare Research and Quality, the Armstrong Institute for Patient Safety and Quality and NORC at The University of Chicago are leading a national collaborative project that aims to improve antibiotic stewardship across acute care, long-term care and ambulatory care facilities.

Join an Informational Webinar

Learn about project goals, interventions and expectations of long-term care facilities participating in this program. 

Find additional webinar dates through November.

Enrollment for Ambulatory Care is Now Open

We are seeking ambulatory care facilities in the United States to join the next 12-month cohort, which begins in December 2019. Participating facilities will receive antibiotic use guidelines for common infectious disease syndromes, expert coaching, online training, patient and family education materials, and other resources to use these life-saving medications more effectively. Participation can also help your facility improve compliance with Centers for Medicare & Medicaid Services antibiotic stewardship mandates. Visit the Project Portal for more details.

Why Target Antibiotic Use?

The need for antibiotic stewardship is evident across care settings:

  • Hospitals. About 50% of patients receive antibiotics, with approximately 30% of antibiotic use considered suboptimal.
  • Long-term care facilities. More than 40% of antibiotic use in long-term care facilities is unnecessary or inappropriate.
  • Ambulatory facilities. The majority of antibiotic prescriptions — approximately 60% — occur in this setting, with at least 30% of these prescriptions considered unnecessary.


Led by Johns Hopkins Medicine and NORC at the University of Chicago, this project is funded and guided by the Agency for Healthcare Research and Quality.


Visit the FAQ page of the portal or email us at

Get Updates

Join our contact list to get notifications about this and other projects led by the Armstrong Institute.

back to top button