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Research on Venous Thromboembolism Prevention

The Johns Hopkins Venous Thromboembolism (VTE) Collaborative has been publishing academic journal articles about blood clot prevention and measurement for nearly a decade. These articles have advanced the science of preventing venous thromboembolisms and informed public policy.

Selected Publications

Below is a selection of several published articles that reflect the impact of the VTE Collaborative and the breadth of its research and improvement work. See an annotated bibliography for a full listing of more than 50 articles by the collaborative.

Most Cited Publications

Recent Publications

  • Haut ER, Aboagye JK, Shaffer DL, Wang J, Hobson DB, Yenokyan G, Sugar ES, Kraus PS, Farrow NE, Canner JK, Owodunni OP, Florecki KL, Webster LW, Holzmueller CG, Pronovost PJ, Streiff MB, Lau BD. Effect of Real-time Patient-Centered Education Bundle on Administration of Venous Thromboembolism Prevention in Hospitalized Patients. JAMA Netw Open. 2018;1(7):e184741
    Mini-abstract: In this controlled preintervention-postintervention comparison trial of 19 652 adult patients on medical and surgical units, nonadministration of venous thromboembolism prophylaxis significantly declined on units that received an intervention that combined an alert to a health educator about a missed dose of venous thromboembolism prophylaxis with patient education compared with control units.
  • Murphy PB, Vogt KN, Lau BD, Aboagye JK, Neil GP, Streiff MB, Haut ER. Venous Thromboembolism Prevention in Emergency General Surgery: A Review. JAMA Surg. 2018;153(5):479–486.
    Mini-abstract: In this study we found that Operatively and nonoperatively treated EGS patients are at a comparatively high risk of VTE. Despite gaps in existing literature with respect to this increasing patient population, successful best practices can be applied. Best practices include assessment of VTE risk, optimal prophylaxis, and physician, nurse, and patient education regarding the use of mechanical and pharmacologic VTE prophylaxis and institutional policies.
  • Lau BD, Streiff MB, Pronovost PJ, Haut ER. Venous thromboembolism quality measures fail to accurately measure quality. Circulation. 2018;137(12):1278-1284.
    Mini-abstract: We developed a rubric for defect-free VTE prevention, graded each organizational VTE quality measure, and found that none of the current VTE-related quality measures adequately characterizes VTE prevention efforts or outcomes in hospitalized patients. 

Select Publications

  • Shermock K.M., Lau B.D., Haut E.R., Hobson D.B., Ganetsky V.S., Kraus P.S., Efird L.E., Lehmann C.U., Pinto B.L., Ross P.A., Streiff M.B. Patterns of non-administration of ordered doses of venous thromboembolism prophylaxis: implications for novel intervention strategies. Public Library of Science One (PLoS One) 2013;8(6):e66311.
    Mini-abstract: This retrospective study was carried out to identify efficient intervention strategies based on patterns of non-administration of ordered VTE prophylaxis. Overall, 11.9% of doses were not administered. The small proportion of patients that missed multiple ordered doses accounted for a large majority of non-administered doses.
  • Haut E.R., Lau B.D. Chapter 28: Prevention of Venous Thromboembolism: Brief Update Review. In “Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices.” March 2013. Agency for Healthcare Research and Quality, Rockville, MD.
    Mini-abstract: This chapter reviews current practices in VTE prevention and approaches for improving rates of risk-appropriate VTE prophylaxis.
  • Lau B.D., Haut E.R. Practices to Prevent Venous Thromboembolism: A Brief Review. BMJ Quality & Safety. 2014; 23:187-95.
    Mini-abstract: This article reviews the practices and interventions that have been directed towards improvement of VTE prophylaxis prescription in hospitals from 2001-2012 and assesses their efficacy. The authors recommend provider education and active mandatory tools such as computerized clinical decision support, combined with other interventions.
  • Lau B.D., Haider A.H., Streiff M.B., Lehmann C.U., Kraus P.S., Hobson D.B., Kraenzlin F.S., Zeidan A.M., Pronovost P.J., Haut E.R. Eliminating Health Care Disparities With Mandatory Clinical Decision Support: The Venous Thromboembolism (VTE) Example.Med Care. 2015 Jan;53(1):18-24
    Mini-abstract: This retrospective study was designed to examine the effect of implementation of a computerized clinical decision support (CCDS) tool on race-based and sex-based health care disparities across two distinct clinical services. When the proportion of patients prescribed risk-appropriate, best-practice VTE prophylaxis was evaluated pre-implementation, there were racial disparities in compliance between black and white patients. However, implementation of the CCDS tool improved compliance with best-practice VTE prophylaxis prescription and racial disparities were eliminated.
  • Elder S.L., Hobson D.B., Rand C.S., Streiff M.B., Haut E.R., Efird L.E., Kraus P.S., Lehmann C.U., Shermock K.M. Hidden barriers to the delivery of pharmacologic venous thromboembolism prophylaxis: the role of nursing beliefs and practices. Journal of Patient Safety 2014 March
    Mini-abstract: This study was designed to explore causes of variability in the rate of administration of ordered doses of pharmacological venous thromboembolism prophylaxis among nurses on 12 inpatient hospital units using mixed-methods. Findings from the study showed that nurses on units with low administration rates often believe they have the skills to determine which patients require pharmacological venous thromboembolism prophylaxis and are more likely to offer the medication as optional to patients.
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