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Research on Venous Thromboembolism Prevention
The Johns Hopkins Venous Thromboembolism (VTE) Collaborative has been publishing academic journal articles about blood clot prevention and measurement for nearly a decade. These articles have advanced the science of preventing venous thromboembolisms and informed public policy.
Below is a selection of several published articles that reflect the impact of the VTE Collaborative and the breadth of its research and improvement work. See an annotated bibliography for a full listing of more than 50 articles by the collaborative.
Most Cited Publications
- Haut E.R., Pronovost P.J. Surveillance Bias in Outcomes Reporting. JAMA – J Am Med Assoc. 2011; 305(23):2462-3.
Mini-abstract: This article tries to draw attention to the significant risk of surveillance bias inherent in measurement of performance through reported outcome measures in the absence of standardized surveillance.
- Segal J.B., Streiff M.B., Hofmann L.V., Thornton K., Bass E.B. (2007). Management of venous thromboembolism: A systematic review for a practice guideline. Annals of Internal Medicine, 146(3), 211-222.
Mini-abstract: This articles reviewed the evidence on the efficacy of interventions for treatment of deep venous thrombosis (DVT) and pulmonary embolism.
- Pierce C.A., Haut E.R., Kardooni S., Chang D.C., Efron D.T., Haider A., Pronovost P.J., Cornwell E.E. 3rd. Surveillance bias and deep vein thrombosis in the national trauma data bank: The more we look, the more we find. J Trauma. 2008;64(4):932-6; discussion 936-7.
Mini-abstract: The results of this study indicate that hospital DVT rate has a positive association with hospital duplex rate among trauma centers in the NTDB. It provides further evidence that hospital DVT rate is a poor quality indicator in trauma because of the presence of surveillance bias
- Streiff M.B., Carolan H.T., Hobson D.B., Kraus P.S., Holzmueller C.G., Demski R., Lau B.D., Biscup-Horn P., Pronovost P.J., Haut E.R. Lessons from the Johns Hopkins Multi-Disciplinary Venous Thromboembolism (VTE) Prevention Collaborative. BMJ 2012;344:e3935
Mini-abstract: This study describes the experience of the Johns Hopkins VTE Collaborative in implementing a prospective quality improvement program which featured a mandatory clinical decision support tool for VTE risk stratification and risk-appropriate VTE prophylaxis for all hospitalized adult patients. Implementation of the tool resulted in a marked increase in risk-appropriate VTE prophylaxis.
- Haut E.R., Lau B.D., Kraenzlin F.S., Hobson D.B., Kraus P.S., Carolan H.T., Haider A.H., Holzmueller C.G., Efron D.T., Pronovost P.J., Streiff M.B. Improved Prophylaxis and Decreased Rates of Preventable Harm With the Use of a Mandatory Computerized Clinical Decision Support Tool for Prophylaxis for Venous Thromboembolism in Trauma. Archives of Surgery 2012;147(10):901-7.
Mini-abstract: This study was designed to evaluate the impact of a mandatory clinical decision support tool on compliance with prophylaxis for venous thromboembolism and VTE outcomes among admitted trauma patients. Implementation of this tool was found to significantly increase compliance with VTE prophylaxis and decrease the rate of preventable harm.
- Haut E.R., Noll K., Efron D.T., Berenholz S.M., Haider A., Cornwell E.E. 3rd, Pronovost P.J. Can Increased Incidence of Deep Vein Thrombosis (DVT) Be Used as a Marker of Quality of Care in the Absence of Standardized Screening? The Potential Effect of Surveillance Bias on Reported DVT Rates. J Trauma. 2007; 63(5):1132-1137
Mini-abstract: This retrospective study was designed to determine whether or not the rate of DVT identification increases as the number of screening duplex examinations in trauma patients increase.
- Streiff M.B., Haut E.R. The CMS Ruling on Venous Thromboembolism After Total Knee or Hip Arthroplasty: Weighing Risks and Benefits. JAMA – J Am Med Assoc. 2009; 301(10):1063-1065.
Mini-abstract: This article comments on the designation of deep venous thrombosis and pulmonary embolism after total knee arthroplasty and total hip arthroplasty to the list of never events. It argues that the CMS rule may have a number of unintended consequences that could cause additional harm to patients undergoing TKA and THA.
- Haut E.R., Schneider E.B., Patel A., Streiff M.B., Haider A.H., Stevens K.A., Chang D.C., Neal M.L., Hoeft C., Nathens A.B., Cornwell E.E. 3rd, Pronovost P.J., Efron D.T. Duplex Ultrasound Screening For Deep Vein Thrombosis in Asymptomatic Trauma Patients: A Survey of Individual Trauma Surgeon Opinions and Current Trauma Center Practices. J Trauma. 2011; 70(1):27-34.
Mini-abstract: This study surveyed trauma surgeons to obtain opinions regarding duplex ultrasound screening for DVT in asymptomatic trauma patients. There was wide variation in trauma surgeons’ opinions and trauma centers’ practices regarding duplex ultrasound screening for DVT in asymptomatic trauma patients.
- Streiff M.B., Brady J.P., Grant A.M., Grosse S.D., Wong B., Popovic T. CDC Grand Rounds: Preventing Hospital-Associated Venous Thromboembolism; Johns Hopkins Medical Institutions Anticoagulation Management Service. MMWR Morb Mortal Wkly Rep. 2014 Mar 7;63(9):190-3. PMID: 24598595 [PubMed - in process]
Mini-abstract: This Morbidity and Mortality Weekly Report provides an overview of the epidemiology and pathogenesis of venous thromboembolism and describes institutional efforts to improve venous thromboembolism prophylaxis at the Johns Hopkins Hospital, venous thromboembolism prevention as a component of patient safety and public health strategies to prevent venous thromboembolism.
- Zeidan A.M., Streiff M.B., Lau B.D., Ahmed S.R., Kraus P.S., Hobson D.B., Carolan H., Lambrianidi C., Horn P.B., Shermock K.M., Tinoco G., Siddiqui S., Haut E.R. Impact of a Venous Thromboembolism (VTE) Prophylaxis “Smart Order Set”: Improved Compliance, Fewer Events. American Journal of Hematology 2013;88(7):545-549.
Mini-abstract: The objective of this retrospective cohort study was to examine the impact of a “smart order set” on VTE prophylaxis and events in medical inpatients. The “smart order set” increased the prescription of risk-appropriate prophylaxis and reduced the number of symptomatic VTE episodes without increasing the frequency of VTE-prophylaxis associated major bleeding.
- Haut ER, Aboagye JK, Shaffer DL, Wang J, Hobson DB, Yenokyan G, Sugar ES, Kraus PS, Farrow NE, Canner JK, Owodunni OP, Florecki KL, Webster LW, Holzmueller CG, Pronovost PJ, Streiff MB, Lau BD. Effect of Real-time Patient-Centered Education Bundle on Administration of Venous Thromboembolism Prevention in Hospitalized Patients. JAMA Netw Open. 2018;1(7):e184741
Mini-abstract: In this controlled preintervention-postintervention comparison trial of 19 652 adult patients on medical and surgical units, nonadministration of venous thromboembolism prophylaxis significantly declined on units that received an intervention that combined an alert to a health educator about a missed dose of venous thromboembolism prophylaxis with patient education compared with control units.
- Murphy PB, Vogt KN, Lau BD, Aboagye JK, Neil GP, Streiff MB, Haut ER. Venous Thromboembolism Prevention in Emergency General Surgery: A Review. JAMA Surg. 2018;153(5):479–486.
Mini-abstract: In this study we found that Operatively and nonoperatively treated EGS patients are at a comparatively high risk of VTE. Despite gaps in existing literature with respect to this increasing patient population, successful best practices can be applied. Best practices include assessment of VTE risk, optimal prophylaxis, and physician, nurse, and patient education regarding the use of mechanical and pharmacologic VTE prophylaxis and institutional policies.
- Lau BD, Streiff MB, Pronovost PJ, Haut ER. Venous thromboembolism quality measures fail to accurately measure quality. Circulation. 2018;137(12):1278-1284.
Mini-abstract: We developed a rubric for defect-free VTE prevention, graded each organizational VTE quality measure, and found that none of the current VTE-related quality measures adequately characterizes VTE prevention efforts or outcomes in hospitalized patients.
- Shermock K.M., Lau B.D., Haut E.R., Hobson D.B., Ganetsky V.S., Kraus P.S., Efird L.E., Lehmann C.U., Pinto B.L., Ross P.A., Streiff M.B. Patterns of non-administration of ordered doses of venous thromboembolism prophylaxis: implications for novel intervention strategies. Public Library of Science One (PLoS One) 2013;8(6):e66311.
Mini-abstract: This retrospective study was carried out to identify efficient intervention strategies based on patterns of non-administration of ordered VTE prophylaxis. Overall, 11.9% of doses were not administered. The small proportion of patients that missed multiple ordered doses accounted for a large majority of non-administered doses.
- Haut E.R., Lau B.D. Chapter 28: Prevention of Venous Thromboembolism: Brief Update Review. In “Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices.” March 2013. Agency for Healthcare Research and Quality, Rockville, MD.
Mini-abstract: This chapter reviews current practices in VTE prevention and approaches for improving rates of risk-appropriate VTE prophylaxis.
- Lau B.D., Haut E.R. Practices to Prevent Venous Thromboembolism: A Brief Review. BMJ Quality & Safety. 2014; 23:187-95.
Mini-abstract: This article reviews the practices and interventions that have been directed towards improvement of VTE prophylaxis prescription in hospitals from 2001-2012 and assesses their efficacy. The authors recommend provider education and active mandatory tools such as computerized clinical decision support, combined with other interventions.
- Lau B.D., Haider A.H., Streiff M.B., Lehmann C.U., Kraus P.S., Hobson D.B., Kraenzlin F.S., Zeidan A.M., Pronovost P.J., Haut E.R. Eliminating Health Care Disparities With Mandatory Clinical Decision Support: The Venous Thromboembolism (VTE) Example.Med Care. 2015 Jan;53(1):18-24
Mini-abstract: This retrospective study was designed to examine the effect of implementation of a computerized clinical decision support (CCDS) tool on race-based and sex-based health care disparities across two distinct clinical services. When the proportion of patients prescribed risk-appropriate, best-practice VTE prophylaxis was evaluated pre-implementation, there were racial disparities in compliance between black and white patients. However, implementation of the CCDS tool improved compliance with best-practice VTE prophylaxis prescription and racial disparities were eliminated.
- Elder S.L., Hobson D.B., Rand C.S., Streiff M.B., Haut E.R., Efird L.E., Kraus P.S., Lehmann C.U., Shermock K.M. Hidden barriers to the delivery of pharmacologic venous thromboembolism prophylaxis: the role of nursing beliefs and practices. Journal of Patient Safety 2014 March
Mini-abstract: This study was designed to explore causes of variability in the rate of administration of ordered doses of pharmacological venous thromboembolism prophylaxis among nurses on 12 inpatient hospital units using mixed-methods. Findings from the study showed that nurses on units with low administration rates often believe they have the skills to determine which patients require pharmacological venous thromboembolism prophylaxis and are more likely to offer the medication as optional to patients.