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Sara E. Cosgrove, M.D., M.S.

Dr. Sara Cosgrove, MD, MS

Professor of Medicine, Division of Infectious Diseases
Director, Adult Antimicrobial Stewardship Program
Associate Hospital Epidemiologist

Education and Training

M.D., Baylor College of Medicine, Houston, TX (1995)
M.S., Epidemiology, Harvard School of Public Health, Boston, MA (2001)
Residency, Internal Medicine, The Johns Hopkins Hospital, Baltimore, MD (1998)
Fellowship, Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (2001)

Professional Memberships

Society for Healthcare Epidemiology of America (President-Elect 2016, President 2017)
Infectious Diseases Society of America

Clinical and Research Interests

Dr. Cosgrove’s research interests include epidemiology and outcomes of antimicrobial resistance, the development of tools and programs to promote the rational use of antimicrobials, the prevention of hospital-acquired infections and epidemiology and management of Staphylococcus aureus bacteremia.

Selected Publications

  1.  Li DX, Ferrada MA, Avdic E, Tamma PD, Cosgrove SE. Sustained Impact of an Antibiotic Stewardship Intervention for Community-Acquired Pneumonia. Infect Control Hosp Epidemiol. 2016.
  2. Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO, Hamilton CW, Jenkins TC, Lipsett PA, Malani PN, May LS, Moran GJ, Neuhauser MM, Newland JG, Ohl CA, Samore MH, Seo SK, Trivedi KK. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016; 62(10):e51-77.
  3. Tamma PD, Han JH, Rock C, Harris AD, Lautenbach, E, Hsu AJ, Avdic E, Cosgrove SE for the Antibacterial Resistance Leadership Group. Carbapenem therapy is associated with improved survival compared to piperacillin-tazobactam for patients with ESBL bacteremia. Clin Infect Dis. 2015; 60(9):1319-25.
  4. Buckel WR, Avdic E, Carroll KC, Gunaseelan V, Hadhazy E, Cosgrove SE. Gut check: C. difficile testing and treatment in the molecular testing era. Infect Control Hosp Epidemiol. 2015; 36(2):217-21.
  5. Cosgrove SE, Hermsen ED, Rybak MJ, File TM Jr, Parker SK, Barlam TF. Guidance for the knowledge and skills required for antimicrobial stewardship leaders. Infect Control Hosp Epidemiol. 2014; 35(12):1444-51.
  6. Avdic E, Cushinotto LA, Hughes AH, Hansen AR, Efird LE, Bartlett JG, Cosgrove SE. Impact of an antimicrobial stewardship intervention on shortening the duration of therapy for community-acquired pneumonia. Clin Infect Dis. 2012; 54(11):1581-7.
  7. Cosgrove SE, Seo SK, Bolon MK, Sepkowitz KA, Climo MW, Diekema DJ, Speck K, Gunaseelan V, Noskin GA, Herwaldt LA, Wong E, Perl TM for the CDC Prevention Epicenter Program. Evaluation of post-prescription review and feedback as a method of promoting rational antimicrobial use: a multicenter intervention. Infect Control Hosp Epidemiol. 2012; 33(4):374-80.
  8. Cosgrove SE, Boucher HW, Vigliani GA, Campion M, Fowler VG, Abrutyn E, Corey GR, Levine DP, Rupp ME, Chambers HF, Karchmer AW. Initial low-dose gentamicin for S. aureus bacteremia and endocarditis is nephrotoxic. Clin Infect Dis. 2009; 48(6):713-21.
  9. Fowler VG, Boucher HW, Corey GR, Abrutyn E, Karchmer AW, Rupp ME, Levine DP, Chambers HF, Tally FP, Vigliani GA, Cabell CH, Link AS, DeMeyer I, MD, Filler SG, Zervos M, Cook P, Parsonnet J, Bernstein JM, Price CS, Forrest GN, Fätkenheuer G, Gareca M, Rehm SJ, Brodt HR Tice A, Cosgrove SE for the S. aureus Endocarditis and Bacteremia Study Group. Daptomycin versus standard therapy for Staphylococcus aureus bacteremia and endocarditis. N Engl J Med. 2006; 355(7):653-65.
  10. Pronovost PJ, Needham DM, Berenholtz SM, Sinopoli DJ, Chu H, Cosgrove SE, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, DiGiovine B, Kepros J, Goeschel C. A multi-faceted intervention to reduce catheter-related blood stream infections in Michigan intensive care units. N Engl J Med. 2006; 355(26):2725-32.
  11. Tamma PD, Miller MA, Dullabh, Ahn R, Speck K, Gao Y, Scherpf, Cosgrove SE. Association of a safety program for improving antibiotic use with antibiotic use and hospital-onset Clostridioides difficile infection rates among US hospitals. JAMA Network Open. 2021:4(2):e210235. doi:10.1001/jamanetworkopen.2021.0235
  12. Fabre V, Pleiss A, Klein E, Demko Z, Salinas A, Jones G, Gadala A, Hicks LA, Neuhauser MM, Srinivasan A, Cosgrove SE. A pilot study to evaluate the impact of a nurse-driven urine culture diagnostic stewardship intervention on urine cultures in the acute care setting.  Jt Comm J Qual Patient Saf. 2020 Aug 5:S1553-7250(20)30185-9. doi: 10.1016/j.jcjq.2020.07.003.
  13. Fabre V, Klein E, Salinas AB, Jones G, Carroll KC, Milstone AM, Amoah J, Hsu YJ, Gadala A, Desai S, Goyal A, Furfaro D, Zimmerman J, Lin S, Cosgrove SE. A diagnostic stewardship intervention to improve blood culture use among adult nonneutropenic inpatients: the DISTRIBUTE study. J Clin Microbiol. 2020; 22;58(10):e01053-20. 
  14. Goodman KE, Pineles L, Magder LS, Anderson DJ, Ashley ED, Polk RE, Quan H, Trick WE, Woeltje KF, Leekha S, Cosgrove SE, Harris AD. Electronically available patient claims data improve models for comparing antibiotic use across hospitals: results from 576 U.S. facilities. Clin Infect Dis. 2020 Aug [Online ahead of print]. 
  15. Keller SC, Wang NY, Salinas A, Williams D, Townsend J, Cosgrove SE. Which patient discharged to home-based outpatient parenteral antimicrobial therapy are at high risk of adverse events? Open Forum Infect Dis. 2020 May 20;7(6):ofaa178. doi: 10.1093/ofid/ofaa178.
  16. Thom KA, Tamma PD, Harris AD, Dzintars K, Morgan DJ, Li S, Pineles L, Srinivasan A, Avdic E, Cosgrove SE. Impact of a prescriber-driven antibiotic time-out on antibiotic use in hospitalized patients. Clin Infect Dis. 2019 Apr 24;68(9):1581-1584. 
  17. Chotiprasitakul D, Tamma PD, Gadala A, Cosgrove SE. The role of negative methicillin-resistant Staphylococcus aureus nasal surveillance swabs in predicting the need for empiric vancomycin therapy in intensive care unit patients. Infect Control Hosp Epidemiol. 2018; Mar;39(3):290-6. 
  18. Keller SC, Williams D, Gavgani M, Hirsh D, Adamovich J, Hohl D, Gurses AP, Cosgrove SE. Rates of and risk factor for adverse drug events in outpatient parenteral antimicrobial therapy. Clin Infect Dis. 2018; Jan;66(1):11-19.
  19. Avdic E, Wang R, Li DX, Tamma PD, Shulder SE, Carroll KC, Cosgrove SE. Sustained impact of a rapid microarray-based assay with antimicrobial stewardship interventions on optimizing therapy in patients with Gram-positive bacteraemia. J Antimicrob Chemother. 2017; Nov;72(11):3191-8.
  20. Tamma PD, Avdic E, Li DX, Dzintars K, Cosgrove SE. Adverse events associated with antibiotic use in hospitalized patients. JAMA Internal Medicine. 2017 Sep1;177(9):1308-15.
  21. Tamma PD, Avdic E, Keenan JF, Zhao Y, Anand G, Cooper J, Dezube R, Hsu S, Cosgrove SE. What is the more effective antibiotic stewardship intervention, pre-prescription authorization or post-prescription review with feedback? Clin Infect Dis. 2017; Mar 1;64(5):537-543.

Contact Info

600 North Wolfe Street
Halsted 827
Baltimore, MD 21287
Phone: 443-287-4570
Email: scosgro1@jhmi.edu

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