Consulting Services

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With over fifty years of combined mass spectrometry research experience, our team is uniquely qualified to give you the support you need on any mass spec related project. Whether it is designing an experiment to track a group of important compounds, or analyzing multivariate data sets, or just trouble shooting LC-MS instrumentation, we have the solutions and experience to help get the data you need to be successful.

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Experimental Design

Consult with the experts about how best to set up multifactorial, multivariate experiments that are well designed and powered for best results.

Method Development

Use the best approaches to designer assays for your compounds of interest that harness the true power of mass spectrometry. Our experts have years of experience in designing sensitive and specific assays for hard-to-detect targets in important biological pathways.

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Data Analysis

Informatics services provide industry standard quality control, normilization, identification, and quantitation of putative markers and compounds. We are experienced in differential abosolute quantitation and profiling approaches to targeted panels and big data alike.

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Compound Identification

The use of multiple, orthogonal analytical techniques is essential for compound identification. We have experience in separation techniques such as gas chromatography, liquid chromatography, solid phase extraction, and supported liquid extraction. We also have experience in various techniques of mass spectrometry such as triple quadropole (QQQ), time of flight (TOF), and orbitrap mass spectrometry.

Trouble Shooting

Instrumentation and data are never entirely trouble-free. Issues such as peak shape, detector saturation, lack of reproducibility, batch to batch variability, cross-talk, carryover and many more, represent issues that must be dealt with. Addressing these issues before, during, and after data analysis with the appropriate expertise is essential to insure accurate results.

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Grant Writing Support

Putting data in context of the larger scientific context is critical for securing funding. We can also review the experimental design and analytical sections of your grant to maximize your application’s value. If you are in need of an experienced set of eyes to help put your preliminary data in for grant submission, give us a call.

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Metabolomics, Proteomics, and Lipidomics

We have experience in workflows for multi-omics projects that require specialized pipelines for final results.

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Liquid Chromatography and Gas Chromatography

Both liquid chromatography and gas chromatography have their strengths and weaknesses, and choosing the correct approach is essential to quality results.

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Targeted Absolution Quantitation

Differential absolute quantitation is based on isotope dilution mass spectrometry (IDMS) and correct quantitative approaches for maximum sensitivity, specificity, and reproducibility.

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Molecular Profiling

Untargeted data analysis is based on mass, retention time, proprietary libraries, and industry standard libraries.

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Contact Us

If you are interested in how the Molecular Determinants Core can help you meet your research goals, contact us with questions or set up an appointment.